1910genetics
Scientist III, Assay Development and Screening
1910genetics, Boston, Massachusetts, us, 02298
Scientist III, Assay Development and Screening
Computation is revolutionizing drug discovery. Advances in big chemical data, massive computing power, artificial intelligence, and molecular dynamics simulation are changing the way we develop new drugs. At 1910 Genetics, we put computation at the heart of drug discovery, blending expertise in computational chemistry, structural biology, pharmacology, genetics, data science, and software engineering to develop drugs for previously undruggable targets. To assist with our goal of expediting drug discovery, 1910 Genetics seeks a Scientist III, Assay Development and Screening, for an impactful position within our Biology Department. This individual would own the implementation and execution of in vitro assay development and screening strategies, assist in lab automation, manage the lab operations and activities of junior level scientists and CROs, and contribute to progressing lead compounds through our drug discovery process.In this role you will…Design appropriate in vitro biological assays and assist in defining screening funnels for small-molecule drug discovery projects within a variety of therapeutic areas.Develop, optimize, and validate biochemical and cell-based assays in a timely and efficient manner. Prior experience with ELISA, TR-FRET, fluorescence-, and bioluminescence-based assay formats as well as analytical techniques such as HPLC will be a plus.Contribute to compound management, automation, assay development, screening, and data management activities to identify small molecules meeting the Desired Chemical Characteristics (DCC) for each project.Represent in vitro biology on project teams and work closely with colleagues across functional groups, including AI, Chemistry, and DMPK, to progress lead compounds.Ensure experiments and results are documented appropriately in electronic laboratory notebooks and that processes are standardized and documented in SOPs that are rooted in industry standard practices.Maintain clear and efficient communication.Supervise and manage 1-3 Assay Biologists.Ideally you have...A Ph.D. in Biology with a focus in Immunology, Neuroscience, Oncology, or a related field with post-doctoral plus at least 5 years of experience at a high-growth biotechnology or pharmaceutical company.Experience with management of bench scientists.Experience in assay development, high-throughput screening, and automation of biological assays.Expertise in designing and executing screening test funnels to progress compounds from early drug discovery toward preclinical phases.Independence and adeptness in ambiguous situations, flexibility, and comfort in making decisions using minimal available data.A proven ability to work cross-functionally and adapt to changing priorities while managing multiple commitments with accuracy and efficiency to meet deadlines.Extremely generous equity package coupled with competitive salary. Excellent Healthcare benefits (employer covers 90% of insurance premiums).
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Computation is revolutionizing drug discovery. Advances in big chemical data, massive computing power, artificial intelligence, and molecular dynamics simulation are changing the way we develop new drugs. At 1910 Genetics, we put computation at the heart of drug discovery, blending expertise in computational chemistry, structural biology, pharmacology, genetics, data science, and software engineering to develop drugs for previously undruggable targets. To assist with our goal of expediting drug discovery, 1910 Genetics seeks a Scientist III, Assay Development and Screening, for an impactful position within our Biology Department. This individual would own the implementation and execution of in vitro assay development and screening strategies, assist in lab automation, manage the lab operations and activities of junior level scientists and CROs, and contribute to progressing lead compounds through our drug discovery process.In this role you will…Design appropriate in vitro biological assays and assist in defining screening funnels for small-molecule drug discovery projects within a variety of therapeutic areas.Develop, optimize, and validate biochemical and cell-based assays in a timely and efficient manner. Prior experience with ELISA, TR-FRET, fluorescence-, and bioluminescence-based assay formats as well as analytical techniques such as HPLC will be a plus.Contribute to compound management, automation, assay development, screening, and data management activities to identify small molecules meeting the Desired Chemical Characteristics (DCC) for each project.Represent in vitro biology on project teams and work closely with colleagues across functional groups, including AI, Chemistry, and DMPK, to progress lead compounds.Ensure experiments and results are documented appropriately in electronic laboratory notebooks and that processes are standardized and documented in SOPs that are rooted in industry standard practices.Maintain clear and efficient communication.Supervise and manage 1-3 Assay Biologists.Ideally you have...A Ph.D. in Biology with a focus in Immunology, Neuroscience, Oncology, or a related field with post-doctoral plus at least 5 years of experience at a high-growth biotechnology or pharmaceutical company.Experience with management of bench scientists.Experience in assay development, high-throughput screening, and automation of biological assays.Expertise in designing and executing screening test funnels to progress compounds from early drug discovery toward preclinical phases.Independence and adeptness in ambiguous situations, flexibility, and comfort in making decisions using minimal available data.A proven ability to work cross-functionally and adapt to changing priorities while managing multiple commitments with accuracy and efficiency to meet deadlines.Extremely generous equity package coupled with competitive salary. Excellent Healthcare benefits (employer covers 90% of insurance premiums).
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