Bristol-Myers Squibb
Principal Scientist/Antibody Drug Conjugate (ADC) Technology
Bristol-Myers Squibb, Brisbane, California, United States, 94005
Principal Scientist/Antibody Drug Conjugate (ADC) TechnologyWorking with UsChallenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists to prosecute targets and biological pathways with disease-modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.
As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS.
We are looking for an experienced, collaborative, highly motivated scientist and leader with deep expertise in antibody drug conjugates (ADC) technologies. The candidate should have a deep understanding and experience in antibody drug conjugation technologies. The candidate is expected to have strong collaborative skills to ensure robust partnerships with biologists, antibody discovery and engineering & bioanalytical scientists to advance ADC projects.
A proven track record of hands-on experience with antibody-drug conjugation chemistry, analytical characterization, and developability of ADCs is a must-have for this position.
Responsibilities:
Lead and carry out laboratory experiments related to ADC conjugation, associated purification and analytical characterization of the conjugates.
Design, produce, and characterize antibody-drug conjugates (ADCs) with a high degree of independence.
Proactively advise and share knowledge and expert opinions with bench scientists, peers, and senior management. Mentor staff in troubleshooting strategic and experimental issues.
Lead project teams through different stages of pre-clinical discovery.
Ensure the highest standard of quality in antibody-conjugate productions in alignment with product development guidelines and QC criteria.
Collaborate with a diverse team of biologists and chemists to answer scientific questions and drive forward new conjugation platforms.
Leverage knowledge of bioconjugation and protein engineering to develop new therapeutic ADC technologies.
Encourage ideas for continuous improvement activities & new technology development and initiatives within the workgroup.
Contribute to patents, publications, and technical reports.
Basic Qualifications:
Bachelor’s Degree with 8+ years of academic or industry experience.
Or Master’s Degree with 6+ years of academic or industry experience.
Or PhD with 4+ years of academic or industry experience.
Preferred Qualifications:
A PhD with 4+ years of industry experience.
Extensive hands-on experience with therapeutic antibody and ADC discovery.
Deep knowledge of bioconjugation chemistries (lysine, inter-chain cysteine and/or site-specific cysteine and others) is needed.
Experience in development of purification strategies using various chromatographic techniques such as affinity, size exclusion, ion-exchange, hydrophobic interaction, and tangential flow filtration (TFF).
Experience in analytical characterization of ADCs including SEC, RP-HPLC, LC-MS, CE-SDS, ELISA, DSC, and HIC.
Experience with biological assays such as measuring cytotoxic activity for ADC characterization.
Hands-on experience with siRNA/ASO conjugations and analytics is a plus.
Demonstrated record of scientific accomplishments and publications.
Excellent written and oral communication skills and ability to interpret results and contribute to multidisciplinary biologics discovery teams.
For California Sites:
The starting compensation for this job is a range from $121,000 – $167,200, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience.
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as “Transforming patients’ lives through science”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion, and integrity bring out the highest potential of each of our colleagues.
#J-18808-Ljbffr
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists to prosecute targets and biological pathways with disease-modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.
As part of the Discovery Biotherapeutics efforts at BMS, the Principal Scientist will play a key role in advancing antibody drug conjugates technologies at BMS.
We are looking for an experienced, collaborative, highly motivated scientist and leader with deep expertise in antibody drug conjugates (ADC) technologies. The candidate should have a deep understanding and experience in antibody drug conjugation technologies. The candidate is expected to have strong collaborative skills to ensure robust partnerships with biologists, antibody discovery and engineering & bioanalytical scientists to advance ADC projects.
A proven track record of hands-on experience with antibody-drug conjugation chemistry, analytical characterization, and developability of ADCs is a must-have for this position.
Responsibilities:
Lead and carry out laboratory experiments related to ADC conjugation, associated purification and analytical characterization of the conjugates.
Design, produce, and characterize antibody-drug conjugates (ADCs) with a high degree of independence.
Proactively advise and share knowledge and expert opinions with bench scientists, peers, and senior management. Mentor staff in troubleshooting strategic and experimental issues.
Lead project teams through different stages of pre-clinical discovery.
Ensure the highest standard of quality in antibody-conjugate productions in alignment with product development guidelines and QC criteria.
Collaborate with a diverse team of biologists and chemists to answer scientific questions and drive forward new conjugation platforms.
Leverage knowledge of bioconjugation and protein engineering to develop new therapeutic ADC technologies.
Encourage ideas for continuous improvement activities & new technology development and initiatives within the workgroup.
Contribute to patents, publications, and technical reports.
Basic Qualifications:
Bachelor’s Degree with 8+ years of academic or industry experience.
Or Master’s Degree with 6+ years of academic or industry experience.
Or PhD with 4+ years of academic or industry experience.
Preferred Qualifications:
A PhD with 4+ years of industry experience.
Extensive hands-on experience with therapeutic antibody and ADC discovery.
Deep knowledge of bioconjugation chemistries (lysine, inter-chain cysteine and/or site-specific cysteine and others) is needed.
Experience in development of purification strategies using various chromatographic techniques such as affinity, size exclusion, ion-exchange, hydrophobic interaction, and tangential flow filtration (TFF).
Experience in analytical characterization of ADCs including SEC, RP-HPLC, LC-MS, CE-SDS, ELISA, DSC, and HIC.
Experience with biological assays such as measuring cytotoxic activity for ADC characterization.
Hands-on experience with siRNA/ASO conjugations and analytics is a plus.
Demonstrated record of scientific accomplishments and publications.
Excellent written and oral communication skills and ability to interpret results and contribute to multidisciplinary biologics discovery teams.
For California Sites:
The starting compensation for this job is a range from $121,000 – $167,200, plus incentive cash and stock opportunities (based on eligibility). The starting pay takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation is decided based on demonstrated experience.
If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.
Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as “Transforming patients’ lives through science”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion, and integrity bring out the highest potential of each of our colleagues.
#J-18808-Ljbffr