University of California - San Francisco
Liu Lab - Junior or Assistant Specialist
University of California - San Francisco, San Francisco, California, United States, 94199
Application WindowOpen date:
August 14, 2024Next review date:
Tuesday, Oct 1, 2024 at 11:59pm (Pacific Time)Apply by this date to ensure full consideration by the committee.Final date:
Saturday, Feb 14, 2026 at 11:59pm (Pacific Time)Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.Position description
The Liu Laboratory within the UCSF Departments of Radiation Oncology and Neurological Surgery is recruiting a highly motivated candidate with prior laboratory experience to fill a specialist position.The Liu Lab focuses on developing new treatments for patients with malignancies of the central nervous system by:Studying the mechanisms through which brain tumors develop and become resistant to treatments.Identifying novel therapeutic targets using molecular biology, CRISPR genome and epigenome editing, biochemistry, mouse genetics, bioinformatics, pharmacology, and multidisciplinary collaborations.We work collaboratively with basic scientists, computational biologists, and physician-scientists at the UCSF Helen Diller Cancer Center and broadly throughout the UCSF Campuses. Please refer to
https://liulab.ucsf.edu
for an overview of our research efforts.Under direct supervision and guidance, the Junior or Assistant Specialist will play an instrumental role in developing and deploying genetic and epigenetic editing technologies for treating malignant gliomas, working side-by-side with physician-scientist Dr. John Liu (MD/PhD Assistant Professor).This project will involve collaboration across the labs of the UCSF Brain Tumor Center as well as the UCSF Preclinical Therapeutics Core. The employee will learn and utilize a variety of research techniques and have the opportunity to be a co-author on publications as well as present at international conferences.Under direct supervision and guidance, the job responsibilities and opportunities include but are not limited to:Molecular biology including molecular cloning, PCR, DNA/RNA/Protein analysis, DNA methylation epigenetic analysis including bisulfite sequencing.Culturing human and mouse cancer cell lines, primary brain tumor cultures, and organoids.Flow cytometry, immunofluorescence, and confocal microscopy analysis.Performing gene knockdown and epigenetic editing using engineered CRISPR/Cas9 technologies, including genome-wide CRISPR screens.Assisting with mouse colony management, including breeding, weaning, tagging, and PCR genotyping.Assisting with intracranial xenograft studies and pharmacologic experiments in mice.Dissection and dissociation of tumor xenografts for single cell RNA-seq and multi-omics analysis.Assisting with lab maintenance duties including acquisition of materials and documentation.Prior familiarity with these techniques is a plus but not required, and a willingness to learn new techniques is expected. In addition, the successful applicant will receive direct mentorship to ensure that specific laboratory responsibilities are tailored and directed toward future career objectives, such as the pursuit of a MD, biomedical PhD, or MD/PhD.Required Qualifications:Specialists appointed at the Junior rank must possess a baccalaureate degree (or equivalent degree) or at least four years of research experience.Specialists appointed at the Assistant rank must possess a master's degree or a baccalaureate degree with 3 or more years of research experience.Strong degree of self-motivation, eagerness to learn and think critically, and enthusiasm for science and/or medicine.Attention to detail and problem-solving ability.Demonstrated reliability and integrity.Strong organizational, communication, and documentation skills.Initiative to work well as part of a team and also independently.Preferred Qualifications:Basic knowledge and understanding of cancer biology.Effective use of laboratory instruments and their maintenance; knowledge of biomedical and biotechnological techniques and methodologies.Working knowledge in tissue culture and basic molecular/cell biology.Knowledge and experience with CRISPR/Cas9 techniques.Please apply online at
https://aprecruit.ucsf.edu/JPF05224 . Applicants' materials must list current and/or pending qualifications upon submission.See Table 24B for the salary range for this position. A reasonable estimate for this position is $53,100-$68,300.Application Requirements
Document requirementsCurriculum Vitae - CV must clearly list current and/or pending qualifications (e.g. board eligibility/certification, medical licensure, etc.).Cover LetterStatement of Research (Optional)Statement of Teaching (Optional)Statement of Contributions to Diversity - Please see the following page for more details: Contributions to Diversity Statement (Optional)Misc / Additional (Optional)Reference requirements2-4 required (contact information only)About UC San Francisco
As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.Job location
San Francisco, CA
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August 14, 2024Next review date:
Tuesday, Oct 1, 2024 at 11:59pm (Pacific Time)Apply by this date to ensure full consideration by the committee.Final date:
Saturday, Feb 14, 2026 at 11:59pm (Pacific Time)Applications will continue to be accepted until this date, but those received after the review date will only be considered if the position has not yet been filled.Position description
The Liu Laboratory within the UCSF Departments of Radiation Oncology and Neurological Surgery is recruiting a highly motivated candidate with prior laboratory experience to fill a specialist position.The Liu Lab focuses on developing new treatments for patients with malignancies of the central nervous system by:Studying the mechanisms through which brain tumors develop and become resistant to treatments.Identifying novel therapeutic targets using molecular biology, CRISPR genome and epigenome editing, biochemistry, mouse genetics, bioinformatics, pharmacology, and multidisciplinary collaborations.We work collaboratively with basic scientists, computational biologists, and physician-scientists at the UCSF Helen Diller Cancer Center and broadly throughout the UCSF Campuses. Please refer to
https://liulab.ucsf.edu
for an overview of our research efforts.Under direct supervision and guidance, the Junior or Assistant Specialist will play an instrumental role in developing and deploying genetic and epigenetic editing technologies for treating malignant gliomas, working side-by-side with physician-scientist Dr. John Liu (MD/PhD Assistant Professor).This project will involve collaboration across the labs of the UCSF Brain Tumor Center as well as the UCSF Preclinical Therapeutics Core. The employee will learn and utilize a variety of research techniques and have the opportunity to be a co-author on publications as well as present at international conferences.Under direct supervision and guidance, the job responsibilities and opportunities include but are not limited to:Molecular biology including molecular cloning, PCR, DNA/RNA/Protein analysis, DNA methylation epigenetic analysis including bisulfite sequencing.Culturing human and mouse cancer cell lines, primary brain tumor cultures, and organoids.Flow cytometry, immunofluorescence, and confocal microscopy analysis.Performing gene knockdown and epigenetic editing using engineered CRISPR/Cas9 technologies, including genome-wide CRISPR screens.Assisting with mouse colony management, including breeding, weaning, tagging, and PCR genotyping.Assisting with intracranial xenograft studies and pharmacologic experiments in mice.Dissection and dissociation of tumor xenografts for single cell RNA-seq and multi-omics analysis.Assisting with lab maintenance duties including acquisition of materials and documentation.Prior familiarity with these techniques is a plus but not required, and a willingness to learn new techniques is expected. In addition, the successful applicant will receive direct mentorship to ensure that specific laboratory responsibilities are tailored and directed toward future career objectives, such as the pursuit of a MD, biomedical PhD, or MD/PhD.Required Qualifications:Specialists appointed at the Junior rank must possess a baccalaureate degree (or equivalent degree) or at least four years of research experience.Specialists appointed at the Assistant rank must possess a master's degree or a baccalaureate degree with 3 or more years of research experience.Strong degree of self-motivation, eagerness to learn and think critically, and enthusiasm for science and/or medicine.Attention to detail and problem-solving ability.Demonstrated reliability and integrity.Strong organizational, communication, and documentation skills.Initiative to work well as part of a team and also independently.Preferred Qualifications:Basic knowledge and understanding of cancer biology.Effective use of laboratory instruments and their maintenance; knowledge of biomedical and biotechnological techniques and methodologies.Working knowledge in tissue culture and basic molecular/cell biology.Knowledge and experience with CRISPR/Cas9 techniques.Please apply online at
https://aprecruit.ucsf.edu/JPF05224 . Applicants' materials must list current and/or pending qualifications upon submission.See Table 24B for the salary range for this position. A reasonable estimate for this position is $53,100-$68,300.Application Requirements
Document requirementsCurriculum Vitae - CV must clearly list current and/or pending qualifications (e.g. board eligibility/certification, medical licensure, etc.).Cover LetterStatement of Research (Optional)Statement of Teaching (Optional)Statement of Contributions to Diversity - Please see the following page for more details: Contributions to Diversity Statement (Optional)Misc / Additional (Optional)Reference requirements2-4 required (contact information only)About UC San Francisco
As a University employee, you will be required to comply with all applicable University policies and/or collective bargaining agreements, as may be amended from time to time. Federal, state, or local government directives may impose additional requirements.UC San Francisco seeks candidates whose experience, teaching, research, or community service has prepared them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age or protected veteran status.Job location
San Francisco, CA
#J-18808-Ljbffr