Association TRENDS
Post-Doctoral Research Fellow
Association TRENDS, Seattle, Washington, us, 98127
OverviewFred Hutchinson Cancer Center is an independent, nonprofit organization providing adult cancer treatment and groundbreaking research focused on cancer and infectious diseases. Based in Seattle, Fred Hutch is the only National Cancer Institute-designated cancer center in Washington.With a track record of global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy and COVID-19 vaccines, Fred Hutch has earned a reputation as one of the world's leading cancer, infectious disease and biomedical research centers. Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world's deadliest diseases and make life beyond cancer a reality.At Fred Hutch we value collaboration, compassion, determination, excellence, innovation, integrity and respect. These values are grounded in and expressed through the principles of diversity, equity and inclusion. Our mission is directly tied to the humanity, dignity and inherent value of each employee, patient, community member and supporter. Our commitment to learning across our differences and similarities make us stronger. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an anti-racist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, anti-racism and inclusion.The Veatch lab in the Clinical Research Division at the Fred Hutch Cancer Center is recruiting a
Post-Doctoral Research Fellow
with expertise in immunology to lead a project developing novel T cell therapies in solid tumors. The Veatch lab focuses on strategies of enhancing tumor specific T cell responses in cancer patients and mouse models, with a focus on CD4 T cells that orchestrate the immune responses of CD8 T cells, B cells and myeloid cells, with the goal of developing strategies to activate the tumor immune microenvironment that can be readily translated into the clinic.ResponsibilitiesThe candidate would lead a project centered on the development of CD4 T cell based therapies through use of humanized mouse models of cancer, and by identifying and expanding tumor specific CD4 T cell populations from human tumors. The work would involve using methods of molecular biology (cloning, CRISPR/Cas9 gene editing), cellular immunology, in vivo work with mouse models, multi-parameter flow cytometry, single-cell genomics and high dimensional spatial analysis. This work will also involve working with samples derived from cancer patients, and we hope will lead to a first in human clinical trial of this approach.QualificationsMINIMUM QUALIFICATIONS:PhD in immunology, tumor biology, or related fieldExperience or interest in working with complex mouse tumor modelsEligibility and desire to apply for future fellowshipsEvidence of productivity, creativity, and strong analytical and interpersonal skillsThe candidate should be enthusiastic about this research area, goal-oriented, a self-starter, and be able to work independently in a team environmentPREFERRED QUALIFICATIONS:Expertise in multiparameter flow cytometry (10+ colors)Experience working with mouse models and familiarity with various handling techniques (e.g. tail vein, retro-orbital, subcutaneous injections)Experience with CRISPR/Cas9 gene-editingExperience in next generation sequencing data analysis, particularly for single cell RNAseq and TCR sequencingExcellent knowledge of fundamental immunologyStrong analytical, writing, communication, and problem-solving skills are desiredCover letters and contact information for 2-3 professional or academic references are highly desired from applicants.A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.The annual base salary range for this position is from $67,728 to $140,000 and pay offered will be based on experience and qualifications.This position may be eligible for relocation assistance. Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, income-based child care subsidy, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (13 days per year), and paid parental leave (up to 4 weeks).Our Commitment to DiversityWe are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to Human Resources at hrops@fredhutch.org or by calling 206-667-4700.
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Post-Doctoral Research Fellow
with expertise in immunology to lead a project developing novel T cell therapies in solid tumors. The Veatch lab focuses on strategies of enhancing tumor specific T cell responses in cancer patients and mouse models, with a focus on CD4 T cells that orchestrate the immune responses of CD8 T cells, B cells and myeloid cells, with the goal of developing strategies to activate the tumor immune microenvironment that can be readily translated into the clinic.ResponsibilitiesThe candidate would lead a project centered on the development of CD4 T cell based therapies through use of humanized mouse models of cancer, and by identifying and expanding tumor specific CD4 T cell populations from human tumors. The work would involve using methods of molecular biology (cloning, CRISPR/Cas9 gene editing), cellular immunology, in vivo work with mouse models, multi-parameter flow cytometry, single-cell genomics and high dimensional spatial analysis. This work will also involve working with samples derived from cancer patients, and we hope will lead to a first in human clinical trial of this approach.QualificationsMINIMUM QUALIFICATIONS:PhD in immunology, tumor biology, or related fieldExperience or interest in working with complex mouse tumor modelsEligibility and desire to apply for future fellowshipsEvidence of productivity, creativity, and strong analytical and interpersonal skillsThe candidate should be enthusiastic about this research area, goal-oriented, a self-starter, and be able to work independently in a team environmentPREFERRED QUALIFICATIONS:Expertise in multiparameter flow cytometry (10+ colors)Experience working with mouse models and familiarity with various handling techniques (e.g. tail vein, retro-orbital, subcutaneous injections)Experience with CRISPR/Cas9 gene-editingExperience in next generation sequencing data analysis, particularly for single cell RNAseq and TCR sequencingExcellent knowledge of fundamental immunologyStrong analytical, writing, communication, and problem-solving skills are desiredCover letters and contact information for 2-3 professional or academic references are highly desired from applicants.A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.The annual base salary range for this position is from $67,728 to $140,000 and pay offered will be based on experience and qualifications.This position may be eligible for relocation assistance. Fred Hutchinson Cancer Center offers employees a comprehensive benefits package designed to enhance health, well-being, and financial security. Benefits include medical/vision, dental, flexible spending accounts, life, disability, retirement, family life support, employee assistance program, onsite health clinic, income-based child care subsidy, tuition reimbursement, paid vacation (22 days per year), paid sick leave (up to 30 calendar days per occurrence of a qualifying reason), paid holidays (13 days per year), and paid parental leave (up to 4 weeks).Our Commitment to DiversityWe are proud to be an Equal Employment Opportunity (EEO) and Vietnam Era Veterans Readjustment Assistance Act (VEVRAA) Employer. We are committed to cultivating a workplace in which diverse perspectives and experiences are welcomed and respected. We do not discriminate on the basis of race, color, religion, creed, ancestry, national origin, sex, age, disability (physical or mental), marital or veteran status, genetic information, sexual orientation, gender identity, political ideology, or membership in any other legally protected class. We are an Affirmative Action employer. We encourage individuals with diverse backgrounds to apply and desire priority referrals of protected veterans. If due to a disability you need assistance/and or a reasonable accommodation during the application or recruiting process, please send a request to Human Resources at hrops@fredhutch.org or by calling 206-667-4700.
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