Takeda Pharmaceuticals
Research Scientist, In Vivo Pharmacology
Takeda Pharmaceuticals, Boston, Massachusetts, us, 02298
By clicking the “Apply” button, I understand that my employment application process with Takeda will commence and that
the information I provide in my application will be processed in line with
Takeda’s
Privacy Notice
and
Terms of Use .
I further attest that all information I submit in my employment application
is
true to the best of my knowledge.Job Description
Research Scientist, In Vivo Pharmacology, GI2
About the role:At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.Join Takeda as an Research Scientist, In Vivo Pharmacology. You will have experience in inflammatory disease, fibrotic and extra-cellular matrix pathobiology, innate and adaptive cell biology and associated in vivo models of disease to join the Gastro-Intestinal Inflammation Research (Drug Discovery Unit).You will possess strong technical skills and primarily be responsible for in vivo experiments with associated ex vivo analysis to further biological understanding and enable a translational medicine strategy for inflammatory / fibrotic diseases of the gastro-intestinal tract and hepato-biliary system. You may also have the opportunity to perform for in vitro experiments. As you grow within the team, you will also execute in vivo models of skin, lung and joint inflammation.You will support a broad pipeline in autoimmune and inflammatory diseases by validating targets, assessing the efficacy of therapeutic candidate molecules from multiple modalities (biologics, small molecules, nucleic acids and cellular therapies).How you will contribute:Proper handling and care of mice and other rodents, general dosing (multiple routes – oral, IV, IP, SC) and surgical techniques and collection and analysis of blood and tissue samples ; work schedule flexibility to ensure optimal dosing schedules on a project specific need will be required on a case by case basis.Understands and implements study protocols in accordance with regulatory requirements for compliance with IACUC guidelines – ability to write IACUC protocols for new models of disease.Independently design and execute in vivo experiments, analyze data and interpret results and present data to relevant stakeholders: Knowledge of data analysis programs such as GraphPad PRISM, MicroSoft Excel Fit, FlowJo FACS analysis, Nanostring transcriptome analysis and Softmax Pro and/or other equivalent software.Maintenance of electronic laboratory notebooks and technical reports to support regulatory submissions as needed.Developing and optimizing project specific mechanistically relevant short term pathway activation as well as disease mouse models of disease - subsequent analysis of PK/PD and associated disease-related pathologies by various techniques such as flow cytometry, histology, protein multiplex ELISAs and focused or full transcriptome / proteome analysis.Troubleshooting methodological and technical issues, interpreting experimental data and literature and communicating results to diverse groups of individuals.Contributing to lab and equipment maintenance and order supplies/reagents to help build a safe, effective and efficient working environment.Collaborates and communicates effectively with team members to coordinate complex in vivo experiments, and with other departments to facilitate cross-functional efforts.Minimum
Requirements/Qualifications:PhD degree in a scientific discipline (or equivalent), orMS with 6+ years relevant experience, or BS with 8+ years relevant experienceYou will have a passion for innovation and desire to lead new scientific directions, being a standout colleague with a collaborative spirit, excellent communication, organization, and time management skills and confident with multitasking and managing multiple projects simultaneously.More about us:At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Takeda Compensation and Benefits SummaryWe understand compensation is
an important factor
as you consider the next step in your career. We are committed to
equitable
pay for all employees, and we strive to be more transparent with our pay practices.For Location:Boston, MA
U.S. Base Salary Range:$108,500.00 - $170,500.00
The estimated salary range reflects
an anticipated
range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education
attained
, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.
The actual base salary offered will be
in accordance with
state or local minimum wage requirements for the job location.U.S. based
e
mployee
s
may be eligible for
s
hort
-
t
erm and/
or
l
ong-
t
erm
incentive
s
.
U.S.
based employees
may be
eligible to
participate
in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and
well-being
benefits, among others. U.S.
based employees are also eligible to receive, per calendar year, up to
80 hours
of sick time, and new hires are eligible to
accrue
up to
120 hours of paid vacation.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.Locations
Boston, MA
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time#J-18808-Ljbffr
the information I provide in my application will be processed in line with
Takeda’s
Privacy Notice
and
Terms of Use .
I further attest that all information I submit in my employment application
is
true to the best of my knowledge.Job Description
Research Scientist, In Vivo Pharmacology, GI2
About the role:At Takeda, we are a forward-looking, world-class R&D organization that unlocks innovation and delivers transformative therapies to patients. By focusing R&D efforts on three therapeutic areas and other targeted investments, we push the boundaries of what is possible in order to bring life-changing therapies to patients worldwide.Join Takeda as an Research Scientist, In Vivo Pharmacology. You will have experience in inflammatory disease, fibrotic and extra-cellular matrix pathobiology, innate and adaptive cell biology and associated in vivo models of disease to join the Gastro-Intestinal Inflammation Research (Drug Discovery Unit).You will possess strong technical skills and primarily be responsible for in vivo experiments with associated ex vivo analysis to further biological understanding and enable a translational medicine strategy for inflammatory / fibrotic diseases of the gastro-intestinal tract and hepato-biliary system. You may also have the opportunity to perform for in vitro experiments. As you grow within the team, you will also execute in vivo models of skin, lung and joint inflammation.You will support a broad pipeline in autoimmune and inflammatory diseases by validating targets, assessing the efficacy of therapeutic candidate molecules from multiple modalities (biologics, small molecules, nucleic acids and cellular therapies).How you will contribute:Proper handling and care of mice and other rodents, general dosing (multiple routes – oral, IV, IP, SC) and surgical techniques and collection and analysis of blood and tissue samples ; work schedule flexibility to ensure optimal dosing schedules on a project specific need will be required on a case by case basis.Understands and implements study protocols in accordance with regulatory requirements for compliance with IACUC guidelines – ability to write IACUC protocols for new models of disease.Independently design and execute in vivo experiments, analyze data and interpret results and present data to relevant stakeholders: Knowledge of data analysis programs such as GraphPad PRISM, MicroSoft Excel Fit, FlowJo FACS analysis, Nanostring transcriptome analysis and Softmax Pro and/or other equivalent software.Maintenance of electronic laboratory notebooks and technical reports to support regulatory submissions as needed.Developing and optimizing project specific mechanistically relevant short term pathway activation as well as disease mouse models of disease - subsequent analysis of PK/PD and associated disease-related pathologies by various techniques such as flow cytometry, histology, protein multiplex ELISAs and focused or full transcriptome / proteome analysis.Troubleshooting methodological and technical issues, interpreting experimental data and literature and communicating results to diverse groups of individuals.Contributing to lab and equipment maintenance and order supplies/reagents to help build a safe, effective and efficient working environment.Collaborates and communicates effectively with team members to coordinate complex in vivo experiments, and with other departments to facilitate cross-functional efforts.Minimum
Requirements/Qualifications:PhD degree in a scientific discipline (or equivalent), orMS with 6+ years relevant experience, or BS with 8+ years relevant experienceYou will have a passion for innovation and desire to lead new scientific directions, being a standout colleague with a collaborative spirit, excellent communication, organization, and time management skills and confident with multitasking and managing multiple projects simultaneously.More about us:At Takeda, we are transforming patient care through the development of novel specialty pharmaceuticals and best in class patient support programs. Takeda is a patient-focused company that will inspire and empower you to grow through life-changing work.Certified as a Global Top Employer, Takeda offers stimulating careers, encourages innovation, and strives for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our teams are united by an unwavering commitment to deliver Better Health and a Brighter Future to people around the world.Takeda Compensation and Benefits SummaryWe understand compensation is
an important factor
as you consider the next step in your career. We are committed to
equitable
pay for all employees, and we strive to be more transparent with our pay practices.For Location:Boston, MA
U.S. Base Salary Range:$108,500.00 - $170,500.00
The estimated salary range reflects
an anticipated
range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education
attained
, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.
The actual base salary offered will be
in accordance with
state or local minimum wage requirements for the job location.U.S. based
e
mployee
s
may be eligible for
s
hort
-
t
erm and/
or
l
ong-
t
erm
incentive
s
.
U.S.
based employees
may be
eligible to
participate
in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and
well-being
benefits, among others. U.S.
based employees are also eligible to receive, per calendar year, up to
80 hours
of sick time, and new hires are eligible to
accrue
up to
120 hours of paid vacation.EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.Locations
Boston, MA
Worker Type
Employee
Worker Sub-Type
Regular
Time Type
Full time#J-18808-Ljbffr