Associate Principal Scientist - Computational Biology/Data Science, AI/ML

Job DescriptionThe Translational Genome Analytics group within the Data, AI & Genome Sciences Department is recruiting an Associate Principal Scientist to join our oncology data science team. We are seeking an experienced and innovative computational scientist to impact our company’s vast and expanding oncology pipeline with a focus on immunotherapy, including personalized neoantigen approaches. The successful candidate will:Analyze, visualize and summarize NGS and other molecular data from oncology clinical trials and proprietary and public large molecular databases, including bulk tissue nucleotide acid sequencing and peripheral comprehensive molecular assays including TCR sequencing, protein profiling, immune activation assays, and liquid biopsies.Leverage cutting-edge AI/ML (e.g. classification and regression algorithms) and integrative analytic methods to investigate proprietary and public immunogenomic datasets in conjunction with tissue and peripheral assays with the goal of improving the detection and utilization of patient-specific neoantigens.Use oncology molecular data to identify biomarkers and molecularly defined groups of patients as well as molecular mechanisms of modulation of therapeutic response reflected in longitudinal analytes, with a focus on identifying novel targets matched to groups of cancer patients with unmet medical need.Effectively present data analyses to inform and interact with stakeholders representing a wide span of internal organizations, including Translational Oncology, Molecular Diagnostics, Clinical Development, Statistics and Therapeutic Area Biology.Education Minimum RequirementPhD (preferred) in Engineering, Applied Mathematics, Bioinformatics, Computational Biology or related field with a significant computational and statistical component and 3+ yrs post-PhD experience or MSc with 10+ yrs experience in applying computational methods in cancer biology in a pharma, biotech or academic setting.Required Experience And SkillsDemonstrated expertise in the application of methods of statistical learning and data mining to the integrative analysis of high-dimensional molecular profiling datasets in the immuno-oncology context.Hands-on analysis experience with algorithms for large genetic, genomic, immunogenomic and clinical datasets (e.g. IEDB, TCGA, GTEx, DepMap).5+ years experience and demonstrated expertise to code in scientific computation environments (R/Python, Matlab) with adoption of best practices for reproducible data analyses.Strong communication and presentation skills; ability to guide and influence decisions through use of data-driven hypotheses; attention to detail.Independent, flexible and collaborative mindset.Preferred Experience And SkillsExperience with analysis of genomic data originating from clinical trials.Understanding of the major concepts of cancer biology as represented in molecular data.Experience with a matrix environment and ability to effectively collaborate with colleagues from a wide range of disciplines.Record of publishing in high profile scientific journals.NOTICE FOR INTERNAL APPLICANTSIn accordance with Managers' Policy - Job Posting and Employee Placement, all employees subject to this policy are required to have a minimum of twelve (12) months of service in current position prior to applying for open positions.If you have been offered a separation benefits package, but have not yet reached your separation date and are offered a position within the salary and geographical parameters as set forth in the Summary Plan Description (SPD) of your separation package, then you are no longer eligible for your separation benefits package. To discuss in more detail, please contact your HRBP or Talent Acquisition Advisor.Employees working in roles that the Company determines require routine collaboration with external stakeholders, such as customer-facing commercial, or research-based roles, will be expected to comply not only with Company policy but also with policies established by such external stakeholders (for example, a requirement to be vaccinated against COVID-19 in order to access a facility or meet with stakeholders).Current Employees apply HERECurrent Contingent Workers apply HEREUS And Puerto Rico Residents OnlyOur company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.AboutWe are an Equal Opportunity Employer, committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status, or other applicable legally protected characteristics.U.S. Hybrid Work ModelEffective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, generally Tuesday, Wednesday and either Monday or Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.Expected Salary Range$137,800.00 - $216,900.00Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days.Requisition ID:

R307660

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