Director, Global HEOR - Chronic Pain

Job Description Director, Global HEOR, Chronic Pain Location:

Boston, MA (3 days onsite, 2 days remote weekly) General Summary: Vertex operates at the forefront of scientific innovation and has successfully developed and commercialized multiple breakthrough medicines for Cystic Fibrosis (CF) as well as Casgevy, a new gene therapy for sickle cell disease and beta-thalassemia. Vertex has more than a dozen ongoing research programs focused on the underlying mechanisms of other serious diseases including programs in Pain, APOL-1 mediated kidney disease (AMKD), and cell therapies for Type 1 diabetes, among others. In consideration of our expanding pipeline and an increasingly complex and challenging commercial environment, Vertex is expanding its Health Economics and Outcomes Research (HEOR) team. The HEOR team works cross-functionally and across regions to envision, create, and communicate compelling evidence supporting the value of Vertex assets for reimbursement and healthcare payers across all stages of the product lifecycle. The Director, HEOR role will serve as the lead for the chronic indications of our Pain portfolio, a series of novel non-opioid analgesics that have the potential to reshape the pain market. The individual will be responsible for leading the development and execution of HEOR strategies primarily for chronic indications across the Vertex Pain portfolio. The role reports to the Senior Director of Global HEOR for the Pain Portfolio. Responsibilities: Lead and execute the HEOR strategy for chronic indications for our Pain portfolio. Serve as the HEOR lead on cross-functional teams to ensure global HEOR strategic plans reflect input of key stakeholders and are aligned with commercial, clinical, medical, RWE, and market access plans. Gather and synthesize insights from Payers, KOLs and HEOR experts; stay current with scientific and policy trends and apply strategic thinking and content expertise to all planning activities. Provide key input to the design of Vertex clinical development and Phase 4 programs to ensure appropriate inclusion of design elements and endpoints relevant to payers, clinicians and patients. Responsible for the development and execution of high quality HEOR evidence and value communication strategies to support optimal funding, payment and access aligned with Pain program objectives. Oversee evidence generation including, CEAs and BIMs, prospective and retrospective observational studies, ITCs, meta-analyses and systematic reviews, PRO measure development and validation, and other research as needed to support the asset value. Collaborate with the Medical Communications teams on publication strategy and ensure that dissemination of HEOR evidence is timely and has maximum impact. Work closely with Global Value and Access Strategy to lead production of product value proposition and deliver compelling and robust Global launch deliverables that support market access (including GVD). Expedite market access with optimal pricing globally by supporting local model adaptations and HTA submissions to ensure accurate, consistent and effective use of HEOR evidence. Lead cross-functional teams in the execution of HEOR projects and initiatives. As a people manager within the organization, may have financial accountabilities and human resource responsibilities for assigned staff. Qualifications: Advanced degree (PhD, MD, MPH, MS or PharmD) in a scientific discipline; clinical background should be supplemented with advanced quantitative training demonstrated by an MPH or MS in a relevant field. Typically requires 10 years of experience in health economics and outcomes research, or directly-related field, and 3 years of supervisory/management experience, or the equivalent combination of education and experience. Excellent written and verbal communication skills. Strong track record of publications in peer-reviewed journals. Superior strategic/tactical planning experience within a pharmaceutical environment is required with deep experience in commercialization and drug development. Excellent communication, presentation, collaboration and influencing skills cross internal and external stakeholders. Recognized as a team player with excellent interpersonal skills who is flexible and reliable. Experience in leading cross-functional teams required. Demonstrated relationship building at all levels of the organization and across geographies. Displays sound ethics and a fit for Vertex’s core values. Skills: In-depth knowledge and ability to apply knowledge of US and global healthcare systems, global HTA requirements, and clinical development, to identify evidence gaps and formulate evidence generation and communication strategies. Subject-matter expert in HEOR able to formulate and lead creative research projects and ensure conduct is technically and scientifically rigorous and reflects best HEOR practices. Culturally competent collaborator able to effectively lead cross-functional teams to ensure alignment with business and stakeholder needs while managing to timelines and budgets. Deep understanding of the drug development process. Assess, synthesize, interpret, and communicate relevant scientific information to internal and external stakeholders. Execute and manage research projects with external collaborates and vendors to ensure timely completion and quality of deliverables as well as budget and legal compliance. Generate peer-reviewed publications to communicate study findings in scientific channels in alignment with the product publication strategy and the overall HEOR evidence generation strategy. Deliver best practice project management oversight for all research and study related activities. Understanding of the legal and regulatory environment of the pharmaceutical industry, with spotless history of compliance and ethical workplace conduct.

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