Society of Exploration Geophysicists
Senior Scientist/Principal Scientist
Society of Exploration Geophysicists, San Diego, California, United States, 92189
In this role, you will:Lead Metabolite Profiling:
Oversee the identification and characterization of metabolites and conduct enzymology studies.Drive Innovation:
Provide scientific and strategic input to guide medicinal chemists in optimizing chemical series and solving complex problems.Collaborate Cross-Functionally:
Work closely with team members to ensure innovative solutions and successful project outcomes.Design and Manage Studies:
Plan and execute in vitro soft-spot and tox species selection MetID studies and definitive in vivo MetID studies.Execute Experimental Work:
Perform laboratory experiments and manage biotransformation studies conducted at CROs.Analyze and Present Data:
Interpret mass spectra, prepare data summaries, and present findings to project teams and management.Contribute to Regulatory Documentation:
Author and support regulatory reports and documents to facilitate clinical development.Requirements:Education & Experience:
PhD in Organic Chemistry, Drug Metabolism, Pharmacokinetics, Pharmaceutical Sciences, or a related discipline with 7+ years of industry experience; alternatively, MS/BS with 12+ years of relevant experience.Expertise:
Extensive knowledge in drug metabolism, in vitro enzyme kinetics, ADME assays, and LC/MS bioanalytical methodologies.Biotransformation Studies:
Proven experience in designing, executing, and reviewing biotransformation studies.Regulatory Knowledge:
Understanding regulatory guidance related to biotransformation, including MIST, with experience in preparing biotransformation documents for regulatory submissions is considered a plus.Core Competencies:Communication Skills:
Exceptional written and verbal technical communication abilities.Leadership & Influence:
Proven ability to lead, guide, and influence teams in decision-making processes.Collaboration:
Strong collaborative skills with the ability to build and maintain relationships across internal scientific functions and the broader scientific community.Autonomy & Teamwork:
Capability to work independently and collaboratively within a multidisciplinary team setting.Data-Driven Analysis:
Passion for data-driven analysis with a solid understanding of business-of-science thinking.Adaptability:
Ability to excel in a fast-paced, highly matrixed environment.Technical Expertise:
Deep knowledge of DMPK, biotransformation, enzymology, and DDI prediction strategies.Track Record:
Demonstrated success in leading studies that support IND filings and contribute to drug discovery.CRO Management:
Proficiency in managing CROs and a strong grasp of relevant regulatory guidance.The ideal candidate will have strong expertise in mass spectrometry, experience with regulatory submissions, and a proven track record of working effectively in a team environment.If you are a highly motivated individual with a passion for DMPK and drug development, apply today to join our innovative team!
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Oversee the identification and characterization of metabolites and conduct enzymology studies.Drive Innovation:
Provide scientific and strategic input to guide medicinal chemists in optimizing chemical series and solving complex problems.Collaborate Cross-Functionally:
Work closely with team members to ensure innovative solutions and successful project outcomes.Design and Manage Studies:
Plan and execute in vitro soft-spot and tox species selection MetID studies and definitive in vivo MetID studies.Execute Experimental Work:
Perform laboratory experiments and manage biotransformation studies conducted at CROs.Analyze and Present Data:
Interpret mass spectra, prepare data summaries, and present findings to project teams and management.Contribute to Regulatory Documentation:
Author and support regulatory reports and documents to facilitate clinical development.Requirements:Education & Experience:
PhD in Organic Chemistry, Drug Metabolism, Pharmacokinetics, Pharmaceutical Sciences, or a related discipline with 7+ years of industry experience; alternatively, MS/BS with 12+ years of relevant experience.Expertise:
Extensive knowledge in drug metabolism, in vitro enzyme kinetics, ADME assays, and LC/MS bioanalytical methodologies.Biotransformation Studies:
Proven experience in designing, executing, and reviewing biotransformation studies.Regulatory Knowledge:
Understanding regulatory guidance related to biotransformation, including MIST, with experience in preparing biotransformation documents for regulatory submissions is considered a plus.Core Competencies:Communication Skills:
Exceptional written and verbal technical communication abilities.Leadership & Influence:
Proven ability to lead, guide, and influence teams in decision-making processes.Collaboration:
Strong collaborative skills with the ability to build and maintain relationships across internal scientific functions and the broader scientific community.Autonomy & Teamwork:
Capability to work independently and collaboratively within a multidisciplinary team setting.Data-Driven Analysis:
Passion for data-driven analysis with a solid understanding of business-of-science thinking.Adaptability:
Ability to excel in a fast-paced, highly matrixed environment.Technical Expertise:
Deep knowledge of DMPK, biotransformation, enzymology, and DDI prediction strategies.Track Record:
Demonstrated success in leading studies that support IND filings and contribute to drug discovery.CRO Management:
Proficiency in managing CROs and a strong grasp of relevant regulatory guidance.The ideal candidate will have strong expertise in mass spectrometry, experience with regulatory submissions, and a proven track record of working effectively in a team environment.If you are a highly motivated individual with a passion for DMPK and drug development, apply today to join our innovative team!
#J-18808-Ljbffr