Dyne Therapeutics
Scientist, Neuromuscular Research
Dyne Therapeutics, Waltham, Massachusetts, United States, 02254
Company Overview:Dyne Therapeutics is a clinical-stage muscle disease company focused on advancing innovative life-transforming therapeutics for people living with genetically driven diseases. With its proprietary FORCE platform, Dyne is developing modern oligonucleotide therapeutics that are designed to overcome limitations in delivery to muscle tissue. Dyne has a broad pipeline for serious muscle diseases, including clinical programs for myotonic dystrophy type 1 (DM1) and Duchenne muscular dystrophy (DMD), and a preclinical program for facioscapulohumeral muscular dystrophy (FSHD).
Role Summary:
The Scientist, Neuromuscular Research role is an exciting opportunity to contribute to the expansion of Dyne's research pipeline, building on the positive clinical data in DMD and DM1 programs. This role will collaborate closely with research and program teams to support the identification and characterization of new targets and the discovery of therapeutics in new indication areas, including neurological diseases. The successful candidate will be involved in all aspects of in vitro and in vivo disease biology, through evaluation of efficacy, pharmacodynamics, pharmacokinetics, and mechanisms of action of our therapeutic molecules. The scientist will lead from the bench and conduct the development and implementation of cell-based and murine disease models to support ongoing projects. As part of the Dyne research team, this individual is an innovative and collaborative team player and a highly motivated self-starter who enjoys working in a fast-paced team setting.
Primary Responsibilities:
Independently design, execute, analyze and interpret in vitro and in vivo studies to establish proof-of-mechanism and proof-of-concept for therapeutic approachesEvaluate and validate disease modelsPrepare and present new disease target proposals including target biology and safety assessmentsWork cross-functionally to plan and execute in vitro and in vivo studiesCollaborate with external research partnersDesign, evaluate, and develop new assays to answer key disease questions to drive programs towards clinical developmentEffectively communicate findings to team members and managementContribute to building a positive culture of teamwork and scientific excellenceStrong organizational skills, multitasking, attention to detail, and ability to effectively document research
Education and Skills Requirements:PhD in neuroscience, molecular biology or related life sciences, or BSc/MSc with 5 or more years of relevant experience will also be consideredExperience conducting in vivo studies with small rodents, including:
Dosing by several routes of administrationTissue collection and processing for downstream assays
Proficiency with cellular and molecular biology techniques including:
Cell cultureELISA and other plate-based assaysWestern blotsGene expression analysis by qPCR or digital PCRAssay development
Ability to develop and implement robust and reproducible assaysExcellent written and oral communication skillsAbility to work efficiently in a fluid cross-functional research environment with limited supervisionAbility to learn quickly and think independentlyProblem-solving skills to identify issues, troubleshoot and develop innovative solutionsExperienced in the use of software applications such as Prism, Excel, and PowerPointExperience in providing scientific and technical leadership applied to novel assay development, advancing challenging drug discovery programs, and mentoring junior colleaguesStrong track record of scientific accomplishments with relevant publications and presentationsExperience managing CROs would be desirableExperience in neuroscience is desirable; however, candidates with relevant qualifications in other disease areas will also be considered
The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.
This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.#J-18808-Ljbffr
Role Summary:
The Scientist, Neuromuscular Research role is an exciting opportunity to contribute to the expansion of Dyne's research pipeline, building on the positive clinical data in DMD and DM1 programs. This role will collaborate closely with research and program teams to support the identification and characterization of new targets and the discovery of therapeutics in new indication areas, including neurological diseases. The successful candidate will be involved in all aspects of in vitro and in vivo disease biology, through evaluation of efficacy, pharmacodynamics, pharmacokinetics, and mechanisms of action of our therapeutic molecules. The scientist will lead from the bench and conduct the development and implementation of cell-based and murine disease models to support ongoing projects. As part of the Dyne research team, this individual is an innovative and collaborative team player and a highly motivated self-starter who enjoys working in a fast-paced team setting.
Primary Responsibilities:
Independently design, execute, analyze and interpret in vitro and in vivo studies to establish proof-of-mechanism and proof-of-concept for therapeutic approachesEvaluate and validate disease modelsPrepare and present new disease target proposals including target biology and safety assessmentsWork cross-functionally to plan and execute in vitro and in vivo studiesCollaborate with external research partnersDesign, evaluate, and develop new assays to answer key disease questions to drive programs towards clinical developmentEffectively communicate findings to team members and managementContribute to building a positive culture of teamwork and scientific excellenceStrong organizational skills, multitasking, attention to detail, and ability to effectively document research
Education and Skills Requirements:PhD in neuroscience, molecular biology or related life sciences, or BSc/MSc with 5 or more years of relevant experience will also be consideredExperience conducting in vivo studies with small rodents, including:
Dosing by several routes of administrationTissue collection and processing for downstream assays
Proficiency with cellular and molecular biology techniques including:
Cell cultureELISA and other plate-based assaysWestern blotsGene expression analysis by qPCR or digital PCRAssay development
Ability to develop and implement robust and reproducible assaysExcellent written and oral communication skillsAbility to work efficiently in a fluid cross-functional research environment with limited supervisionAbility to learn quickly and think independentlyProblem-solving skills to identify issues, troubleshoot and develop innovative solutionsExperienced in the use of software applications such as Prism, Excel, and PowerPointExperience in providing scientific and technical leadership applied to novel assay development, advancing challenging drug discovery programs, and mentoring junior colleaguesStrong track record of scientific accomplishments with relevant publications and presentationsExperience managing CROs would be desirableExperience in neuroscience is desirable; however, candidates with relevant qualifications in other disease areas will also be considered
The statements contained herein reflect general details as necessary to describe the principles functions for this job, the level of knowledge and skill typically required, and the scope of responsibility, but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned, including work in other functional areas to cover absences or relief, to equalize peak work periods or otherwise balance workload.
This description is not intended to be constructed as an exhaustive list of duties, responsibilities, or requirements for the position. This position may change or assume additional duties at any time. The employee may be requested to perform different or additional duties as assigned. All Employees are expected to adhere to all company policies and act as a role model for company values.
Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.#J-18808-Ljbffr