Research Scientist, Synthetic Chemistry

Your ImpactOur Gene Therapy Program aspires to develop single treatment disease cures utilizing Poseida’s best-in-class gene editing tools including piggyBac and Cas-CLOVER. As an integral participant in this effort, you will utilize your skills as a synthetic chemist in collaboration with a multidisciplinary team of innovative, enthusiastic, and highly self-motivated scientists to discover non-viral nanotechnologies that safely and efficiently deliver nucleic acids to target cells in afflicted patients. Your participation will have a direct impact on Poseida’s efforts to cure challenging diseases, including cancer, by expanding the reach of our platform technologies.Position SummaryThe chemistry group at Poseida is seeking a highly motivated and creative synthetic scientist to join our dynamic, fast-paced, and collaborative team. As part of Poseida’s gene therapy efforts, the group’s mission is to develop novel ionizable lipids and conjugates as specific targeting non-viral delivery tools for genome editing and gene therapy applications. This is a laboratory-based position, and this person will design, synthesize, characterize, and optimize novel cationic lipid, polymers, and lipid-like compounds, and work closely with formulation screening, analytical and pharmacology teams within Poseida. The successful candidate will have a strong background in small molecules syntheses, with experience of lipids syntheses and purification will be considered a plus, but not necessary.ResponsibilitiesThese include but are not limited to:Synthesize novel ionizable lipids, cationic polymers, lipid-conjugates, lipid-like compounds, or other molecules suitable for use in nucleic acid delivery in vivo or ex vivo.Independently conduct synthetic planning, purification, and characterization with minimal supervision.Execute scaleup and early process development studies for lead molecules to support preclinical activities.Work closely with formulations and pharmacology teams to establish structure-activity relationships for novel ionizable lipid, lipid-like compounds, and other novel nanoparticle excipients.Analyze and present experimental data to technical and non-technical audiences.Work closely with the IP team and R&D leads to support existing patent strategy and to enable diligent and quick patent filings on new inventions.Follow EHS safety regulations and maintain a safety working environment.Advise the functional group leadership about chemical solutions for the broader research programs, making recommendations, and building the teams to execute accordingly.RequirementsRequirements, Knowledge, Skills, and Abilities:Ph.D. in a scientific discipline (e.g., organic chemistry, medicinal chemistry, polymer science or relevant discipline) with 0-2 years’ relevant industry experience. Bachelor's degree with 10 years or Master’s degree with at least 8 years of relevant industry experience, must have a minimum of 5 years of post-graduate experience (an equivalent combination of education and experience may be considered).Expertise in modern organic synthesis and knowledge on development of non-viral gene delivery platform.Demonstrated experience in syntheses, purifications and characterizations of small organic molecules including heterocycles, carbohydrates, lipids, or closely related compounds.Hands-on experience with FT-IR, NMR, TLC, Column chromatography, HPLC and LCMS.Ability to work independently as well as collaboratively in a results-oriented research team environment.Self-motivated and comfortable with outstanding multidisciplinary organization and multitasking capacity.Who We Are and What We DoBased in San Diego, Poseida Therapeutics is a clinical-stage biopharmaceutical company utilizing our unique and proprietary genetic engineering platform technologies to create next-generation cell and gene therapies with the capacity to cure. We are passionate about making an impact on patients’ lives with the development of our CAR-T therapies in various cancers and gene therapies for rare diseases. Our goal is to deliver potential single treatment cures for patients in need. Our portfolio of product candidates is specifically designed to overcome the limitations of current generation cell and gene therapeutics.At Poseida we put people first. Our team is passionate about improving patients’ lives through innovation. See what our team has to say about our culture:“My favorite part about Poseida is all the people that I get to work with. Everyone is so passionate about what we’re doing here and there’s so much camaraderie. It feels like one big enthusiastic family.”“My favorite part about working at Poseida is the amazing culture and working environment. Everybody is friendly, professional, collaborative, and has a remarkable can-do and positive attitude.”As we advance our compelling pipeline, there are endless opportunities for impact and growth. We encourage you to apply today!

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