Vaxcyte Inc.
Scientist I, Stability
Vaxcyte Inc., San Carlos, California, United States, 94071
Company Profile:Vaxcyte, Inc. (Nasdaq: PCVX)
is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. The Company is developing broad-spectrum conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Vaxcyte’s lead candidate, VAX-24, is a 24-valent, broad-spectrum, carrier-sparing pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease (IPD). The Company is re-engineering the way highly complex immunizations are made through modern synthetic techniques, including advanced chemistry and our exclusively licensed XpressCFTM cell-free protein synthesis platform. Unlike conventional cell-based approaches, the Company’s system for producing difficult-to-make proteins and antigens is intended to accelerate its ability to efficiently create and deliver high-fidelity vaccines with enhanced immunological benefits.Vaxcyte’s pipeline also includes VAX-31, a 31-valent PCV candidate; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease; and VAX-GI, a vaccine program designed to prevent Shigella. The Company is driven to eradicate or treat invasive bacterial infections, which have serious and costly health consequences when left unchecked. For more information, visit
www.vaxcyte.com .Vaxcyte, headquartered in San Carlos, CA, went public in June 2020 and currently has a team of approximately 180 employees and anticipates continued, significant growth. Following equity offerings in October 2022 and April 2023, which generated over $1.1 billion in net proceeds, the Company’s balance sheet is further strengthened to advance its pipeline of novel vaccines, including VAX-24. These financings followed positive data readouts from Vaxcyte’s Phase 1/2 proof-of-concept study evaluating VAX-24 in adults aged 18-64 and Phase 2 study in adults 65 and older. The Company believes these results support a best-in-class potential for VAX-24, which was designed to replace the current standard-of-care in adults and children.Summary:Vaxcyte is looking for an energetic and talented individual to join our Analytical Development and Quality Control Team. The Stability Scientist will assume the critical role of design, plan, execute and coordinate stability studies on development and clinical lots, summarize and analyze results to ensure scientific and technical excellence. Collaborating closely with cross-functional teams, the scientist will play an integral part in guaranteeing the quality, safety, and adherence to regulatory standards of our products. This position is for a scientific role which will be mostly lab based, which will require excellent scientific judgement, independence, rigor and thorough record keeping.The primary responsibility for the incumbent will be to support development stability activities of Vaxcyte’s lead product candidate from early-stage development through Phase 3 and culminating in BLA filing and commercial manufactures.Essential Functions:Initiate and manage vaccine Stability Program activities, including authoring of internal Vaxcyte Stability Protocols and reviewing all stability data – conducting basic trending and statistical analysis for extrapolation.Support development activities such as stability studies for thermal, freeze/thaw, photostability, and new container closure system evaluation for both Drug Substance (DS) and Drug Product (DP) materials.Support in product investigations, working with cross functional teams for investigations related to quality issues, deviations, out-of-specification results, and anomalies at all stages of vaccine development, from early development to late-stage phases.Support coordination of sample distribution and management of data results. Organize and train new personnel on new and emerging stability processes, provide guidance on these techniques to other technical staff.Contribute to the creation of stability data presentations for various key stakeholder meetings.Prepare written summaries of data analyses including figures, tables, as needed for technical reports, scientific papers and patent applications.Maintain thorough and accurate records of laboratory work.Ensure good scientific and technical leadership within the group, keeping updated with current developments in relevant scientific and technical disciplines.Effectively communicate investigation findings and progress to both internal teams and external stakeholders as necessary.Collaborate with external Contract Development Manufacturing Organizations (CDMOs) to facilitate the testing of stability samples, providing essential support for investigative processes.Requirements:Ph.D. or Master's degree in a relevant scientific field (e.g., pharmaceutical sciences, biophysics, biochemistry, or related discipline) is preferred.At least 3-5 years of experience in vaccine analytical development and/or vaccine stability program development.Strong analytical skills, with proficiency in a range of analytical techniques.Strong scientific leadership is required: critical thinking, ability to present complex data sets and to independently propose and design follow-up experiments.The candidate should have high degrees of both flexibility and organizational skills as well as an eagerness and ability to learn in order to effectively navigate Vaxcyte’s multiple projects and timelines.Strong interpersonal skills: ability to communicate effectively both verbally and in written formats are necessary to collaborate effectively with the rest of the Analytical Development and Quality Control team, as well as across other teams.Detail oriented, rigorous and excellent skills in record keeping/documentation.All Vaxcyte employees require vaccination against COVID-19.Reports to:
Director, StabilityLocation:
San Carlos, CACompensation:The compensation package will be competitive and includes comprehensive benefits and an equity component.Salary Range:
$120,000 – $128,000Send resumes to:
careers@vaxcyte.comVaxcyte, Inc.825 Industrial Road, Suite 300San Carlos, CA 94070We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.
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is a vaccine innovation company engineering high-fidelity vaccines to protect humankind from the consequences of bacterial diseases. The Company is developing broad-spectrum conjugate and novel protein vaccines to prevent or treat bacterial infectious diseases. Vaxcyte’s lead candidate, VAX-24, is a 24-valent, broad-spectrum, carrier-sparing pneumococcal conjugate vaccine (PCV) being developed for the prevention of invasive pneumococcal disease (IPD). The Company is re-engineering the way highly complex immunizations are made through modern synthetic techniques, including advanced chemistry and our exclusively licensed XpressCFTM cell-free protein synthesis platform. Unlike conventional cell-based approaches, the Company’s system for producing difficult-to-make proteins and antigens is intended to accelerate its ability to efficiently create and deliver high-fidelity vaccines with enhanced immunological benefits.Vaxcyte’s pipeline also includes VAX-31, a 31-valent PCV candidate; VAX-A1, a prophylactic vaccine candidate designed to prevent Group A Strep infections; VAX-PG, a therapeutic vaccine candidate designed to slow or stop the progression of periodontal disease; and VAX-GI, a vaccine program designed to prevent Shigella. The Company is driven to eradicate or treat invasive bacterial infections, which have serious and costly health consequences when left unchecked. For more information, visit
www.vaxcyte.com .Vaxcyte, headquartered in San Carlos, CA, went public in June 2020 and currently has a team of approximately 180 employees and anticipates continued, significant growth. Following equity offerings in October 2022 and April 2023, which generated over $1.1 billion in net proceeds, the Company’s balance sheet is further strengthened to advance its pipeline of novel vaccines, including VAX-24. These financings followed positive data readouts from Vaxcyte’s Phase 1/2 proof-of-concept study evaluating VAX-24 in adults aged 18-64 and Phase 2 study in adults 65 and older. The Company believes these results support a best-in-class potential for VAX-24, which was designed to replace the current standard-of-care in adults and children.Summary:Vaxcyte is looking for an energetic and talented individual to join our Analytical Development and Quality Control Team. The Stability Scientist will assume the critical role of design, plan, execute and coordinate stability studies on development and clinical lots, summarize and analyze results to ensure scientific and technical excellence. Collaborating closely with cross-functional teams, the scientist will play an integral part in guaranteeing the quality, safety, and adherence to regulatory standards of our products. This position is for a scientific role which will be mostly lab based, which will require excellent scientific judgement, independence, rigor and thorough record keeping.The primary responsibility for the incumbent will be to support development stability activities of Vaxcyte’s lead product candidate from early-stage development through Phase 3 and culminating in BLA filing and commercial manufactures.Essential Functions:Initiate and manage vaccine Stability Program activities, including authoring of internal Vaxcyte Stability Protocols and reviewing all stability data – conducting basic trending and statistical analysis for extrapolation.Support development activities such as stability studies for thermal, freeze/thaw, photostability, and new container closure system evaluation for both Drug Substance (DS) and Drug Product (DP) materials.Support in product investigations, working with cross functional teams for investigations related to quality issues, deviations, out-of-specification results, and anomalies at all stages of vaccine development, from early development to late-stage phases.Support coordination of sample distribution and management of data results. Organize and train new personnel on new and emerging stability processes, provide guidance on these techniques to other technical staff.Contribute to the creation of stability data presentations for various key stakeholder meetings.Prepare written summaries of data analyses including figures, tables, as needed for technical reports, scientific papers and patent applications.Maintain thorough and accurate records of laboratory work.Ensure good scientific and technical leadership within the group, keeping updated with current developments in relevant scientific and technical disciplines.Effectively communicate investigation findings and progress to both internal teams and external stakeholders as necessary.Collaborate with external Contract Development Manufacturing Organizations (CDMOs) to facilitate the testing of stability samples, providing essential support for investigative processes.Requirements:Ph.D. or Master's degree in a relevant scientific field (e.g., pharmaceutical sciences, biophysics, biochemistry, or related discipline) is preferred.At least 3-5 years of experience in vaccine analytical development and/or vaccine stability program development.Strong analytical skills, with proficiency in a range of analytical techniques.Strong scientific leadership is required: critical thinking, ability to present complex data sets and to independently propose and design follow-up experiments.The candidate should have high degrees of both flexibility and organizational skills as well as an eagerness and ability to learn in order to effectively navigate Vaxcyte’s multiple projects and timelines.Strong interpersonal skills: ability to communicate effectively both verbally and in written formats are necessary to collaborate effectively with the rest of the Analytical Development and Quality Control team, as well as across other teams.Detail oriented, rigorous and excellent skills in record keeping/documentation.All Vaxcyte employees require vaccination against COVID-19.Reports to:
Director, StabilityLocation:
San Carlos, CACompensation:The compensation package will be competitive and includes comprehensive benefits and an equity component.Salary Range:
$120,000 – $128,000Send resumes to:
careers@vaxcyte.comVaxcyte, Inc.825 Industrial Road, Suite 300San Carlos, CA 94070We are an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or veteran status.
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