Neogene Therapeutics
Senior Scientist, Analytical Sciences
Neogene Therapeutics, Santa Monica, California, United States, 90403
At AstraZeneca's Oncology R&D division, we follow the science to explore and innovate. We are working towards treating, preventing, modifying, and even curing some of the world's most complex diseases. Here we have the potential to grow our pipeline and positively impact the lives of billions of patients around the world. We are committed to making a difference and have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs.
Position SummaryWe are seeking a Senior Scientist to join our Analytical Sciences (AS) team. You have strong expertise in immuno-oncology and will be focused on the development of fit-for-purpose CMC assays using flow cytometry and cell-based immunoassays, to characterize engineered TCR-T cell drug substance and drug product. This role is based in Santa Monica, CA and reports directly to the Director, Analytical Sciences.
ResponsibilitiesDevelop analytical assays for characterizing T-cell therapy drug substance and drug products using flow cytometers and other immunoassays.Author assay development and qualification reports with solid datasets to evaluate assay characteristics.Perform analytical assays to provide insights for process and product.Drive assay life cycle, including assay optimization, transfer, and qualification.Work with Tech Operations cross-functional teams to draft study protocols, change controls and technical reports.Author and review relevant CMC sections for regulatory submissions.Lead projects and represent bioassay function and communicate progress or issues in CMC sub-team meetings.Perform routine assays as a QC personnel for drug product release and characterization.
Education and Experience7+ years with BS/BA; 5+ years with MS/MA; 2+ years with PhD in Immunology, Oncology, Cell Biology, or related discipline1+ years of management experienceIn-depth knowledge in immunology and cell therapy with hands-on experience working with T cells.Hands-on experience in executing assays and analyzing data using multi-color flow cytometry (+10 colors).First-hand experience in different cell-based assays (e.g., Live imaging, ELISA, or MSD).Prior work experience in a regulated environment (GLP, GMP or QC).Technical-driven, data analysis skills and record keeping abilities.Excellent verbal and written communication for scientific projects.
The annual base salary for this position ranges from
$125,000
to
$149,000 . However, base pay offered may vary depending on multiple individualized factors, including market location and job-related experience. If hired, employee will be in an "at-will position" and we reserve the right to modify base salary (and any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
BenefitsShort-term incentive bonus opportunityEquity-based long-term incentive program401(k) planPaid vacation and holidays; paid leavesHealth benefits including medical, prescription drug, dental, and vision coverage.
DE&I StatementAstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
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Position SummaryWe are seeking a Senior Scientist to join our Analytical Sciences (AS) team. You have strong expertise in immuno-oncology and will be focused on the development of fit-for-purpose CMC assays using flow cytometry and cell-based immunoassays, to characterize engineered TCR-T cell drug substance and drug product. This role is based in Santa Monica, CA and reports directly to the Director, Analytical Sciences.
ResponsibilitiesDevelop analytical assays for characterizing T-cell therapy drug substance and drug products using flow cytometers and other immunoassays.Author assay development and qualification reports with solid datasets to evaluate assay characteristics.Perform analytical assays to provide insights for process and product.Drive assay life cycle, including assay optimization, transfer, and qualification.Work with Tech Operations cross-functional teams to draft study protocols, change controls and technical reports.Author and review relevant CMC sections for regulatory submissions.Lead projects and represent bioassay function and communicate progress or issues in CMC sub-team meetings.Perform routine assays as a QC personnel for drug product release and characterization.
Education and Experience7+ years with BS/BA; 5+ years with MS/MA; 2+ years with PhD in Immunology, Oncology, Cell Biology, or related discipline1+ years of management experienceIn-depth knowledge in immunology and cell therapy with hands-on experience working with T cells.Hands-on experience in executing assays and analyzing data using multi-color flow cytometry (+10 colors).First-hand experience in different cell-based assays (e.g., Live imaging, ELISA, or MSD).Prior work experience in a regulated environment (GLP, GMP or QC).Technical-driven, data analysis skills and record keeping abilities.Excellent verbal and written communication for scientific projects.
The annual base salary for this position ranges from
$125,000
to
$149,000 . However, base pay offered may vary depending on multiple individualized factors, including market location and job-related experience. If hired, employee will be in an "at-will position" and we reserve the right to modify base salary (and any other discretionary payment or compensation program) at any time, including for reasons related to individual performance, Company or individual department/team performance, and market factors.
BenefitsShort-term incentive bonus opportunityEquity-based long-term incentive program401(k) planPaid vacation and holidays; paid leavesHealth benefits including medical, prescription drug, dental, and vision coverage.
DE&I StatementAstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds, with as wide a range of perspectives as possible, and harnessing industry-leading skills. We believe that the more inclusive we are, the better our work will be. We welcome and consider applications to join our team from all qualified candidates, regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment), as well as work authorization and employment eligibility verification requirements.
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