Novartis Farmacéutica
Principal Scientist/Sr. Principal Scientist PK Sciences – DAx DARe TA
Novartis Farmacéutica, Cambridge, Massachusetts, us, 02140
Job ID: REQ-10019820Date: Aug 22, 2024Location: USASummary
The position is located in Cambridge, MA and will not have the ability to be located remotely. This role reports to a PK Sciences (PKS) Dax (renal and liver diseases) and DARe (diseases of aging and regenerative medicine) therapeutic areas within Translational Medicine (TM) in Biomedical Research. PK Sciences plays a pivotal role in bringing innovative medicines to patients, by building on research advances to develop new therapies, bridging drug discovery and clinical application. We are seeking an enthusiastic and motivated PK Sciences project team representative to develop and implement discovery DMPK and/or translational strategies to support the pursuit of transformative new medicines from early discovery through early clinical development.Major Accountabilities
Represent the PK Sciences function in project teams, interactions with stakeholders within the organization and interactions with regulatory agencies, as appropriate.Develop the ADME/PK strategy for lead optimization and oversee the execution of nonclinical studies to identify compounds with favorable DMPK properties.Work with teams to elucidate the understanding of PK/PD relationships and develop dosing strategies and predictions.Develop and execute early clinical development strategies, including input into nonclinical and clinical study design, and analyzing PK and PK/PD data, to support compound development from discovery through development.Author pharmacokinetic/clinical pharmacology/biopharmaceutics sections of IND/IMPDs as well as prepare appropriate responses to Health Authority questions across the globe.Minimum Requirements
Ph.D. / Pharm.D. with relevant experience in clinical pharmacology, drug metabolism and pharmacokinetics or a related background.A minimum of 2 years of experience in drug discovery and/or development in a relevant environment (academia, CRO, biotech or Pharma).4 plus years of experience required to be considered for Senior Principal Scientist level including 2 plus years of experience in a lead role overseeing ADME/DMPK project strategy, in discovery and early clinical development.Extensive and in-depth knowledge of pharmacokinetics including, drug metabolism and PK/PD evaluation.Demonstrated success in working in a cross-functional, matrixed, project-team environment.Strong oral and written communication skills.Benefits and Rewards:Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: Novartis Life Handbook.Commitment to Diversity and Inclusion
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.Why Novartis
Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives.Accessibility & Reasonable Accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information.
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The position is located in Cambridge, MA and will not have the ability to be located remotely. This role reports to a PK Sciences (PKS) Dax (renal and liver diseases) and DARe (diseases of aging and regenerative medicine) therapeutic areas within Translational Medicine (TM) in Biomedical Research. PK Sciences plays a pivotal role in bringing innovative medicines to patients, by building on research advances to develop new therapies, bridging drug discovery and clinical application. We are seeking an enthusiastic and motivated PK Sciences project team representative to develop and implement discovery DMPK and/or translational strategies to support the pursuit of transformative new medicines from early discovery through early clinical development.Major Accountabilities
Represent the PK Sciences function in project teams, interactions with stakeholders within the organization and interactions with regulatory agencies, as appropriate.Develop the ADME/PK strategy for lead optimization and oversee the execution of nonclinical studies to identify compounds with favorable DMPK properties.Work with teams to elucidate the understanding of PK/PD relationships and develop dosing strategies and predictions.Develop and execute early clinical development strategies, including input into nonclinical and clinical study design, and analyzing PK and PK/PD data, to support compound development from discovery through development.Author pharmacokinetic/clinical pharmacology/biopharmaceutics sections of IND/IMPDs as well as prepare appropriate responses to Health Authority questions across the globe.Minimum Requirements
Ph.D. / Pharm.D. with relevant experience in clinical pharmacology, drug metabolism and pharmacokinetics or a related background.A minimum of 2 years of experience in drug discovery and/or development in a relevant environment (academia, CRO, biotech or Pharma).4 plus years of experience required to be considered for Senior Principal Scientist level including 2 plus years of experience in a lead role overseeing ADME/DMPK project strategy, in discovery and early clinical development.Extensive and in-depth knowledge of pharmacokinetics including, drug metabolism and PK/PD evaluation.Demonstrated success in working in a cross-functional, matrixed, project-team environment.Strong oral and written communication skills.Benefits and Rewards:Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: Novartis Life Handbook.Commitment to Diversity and Inclusion
Novartis is committed to building an outstanding, inclusive work environment and diverse teams representative of the patients and communities we serve.Why Novartis
Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives.Accessibility & Reasonable Accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or to perform the essential functions of a position, please send an e-mail to us.reasonableaccommodations@novartis.com or call +1(877)395-2339 and let us know the nature of your request and your contact information.
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