Sarepta Therapeutics
Principal Scientist, Discovery Chemistry
Sarepta Therapeutics, Cambridge, Massachusetts, us, 02140
Principal Scientist, Discovery Chemistry
Apply remote type Onsite locations Cambridge, MA time type Full time posted on Posted 5 Days Ago job requisition id R-02587Why Sarepta? Why Now?The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophies (LGMDs), and we currently have more than 40 programs in various stages of development in gene therapy, RNA and gene editing. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta OffersAt Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:Physical and Emotional WellnessFinancial WellnessSupport for CaregiversFor a full list of our comprehensive benefits, see our website:
https://www.sarepta.com/join-us
The Importance of the RoleThe RNA Research group at Sarepta Therapeutics is seeking a talented, motivated, and experienced scientist to join the dynamic and fast-paced chemistry team located in Cambridge, MA. The successful candidate will work on our PMO oligonucleotide platform and discovery research on improved delivery of oligonucleotides as well as manage collaborations and CROs as needed. This position will work closely with Discovery Biology, Translational Sciences, Business Development and Legal teams to implement new drug discovery programs and advance next generation of RNA therapeutics.The Opportunity to Make a DifferenceDesign and conduct novel oligonucleotide conjugates synthesis, purification, and characterization; Apply state-of-the-art delivery methods to achieve
in vivo
proof of concept; Develop efficient and scalable synthetic methods and routes.Develop and utilize innovative synthetic, medicinal chemistry and/or chemical biology problem solving skills coupled with analysis of diverse data sets to build structure-activity relationships.Act as key member of a multidisciplinary RNA research team, assisting with development of project strategy, and analysis and communication of complex data.Serves as an in-house oligonucleotide and delivery chemistry expert.Drive the writing of technical reports to support patent applications and manuscript preparations.Coordinate and manage collaborations and CRO operations to ensure deliverables meet project needs.Organize workstreams and complete individual and team objectives to maintain project timelines.Supervise and mentor junior staff.More about YouThe ideal candidate will have a PhD with 8+ years in organic chemistry, biochemistry, or related fields industry experience; or M.S. with 12+ years of experience.Strong experience in organic chemistry and multi-step organic synthesis is a must; Hands-on experience with manual and automated systems for solid-phase synthesis of peptides and nucleic acids is essential for this role.Previous experience in the design, chemical optimization, and formulation/delivery of peptides and/or oligonucleotide therapeutics is highly desirable.Experience with using analytical techniques/instrumentation for peptides and/or oligonucleotides purification and characterization such as Reverse Phase (HPLC/UPLC), MALDI-TOF and Liquid Chromatography Mass Spectrometry (LC-MS) is a plus.Track record with the ability to execute multiple concurrent research projects within a cross-functional team environment.Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary.What Now?We’re always looking for solution-oriented, critical thinkers.So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
This position requires work on site at one of Sarepta’s facilities in the United States. The targeted salary range for this position is $140,000 - $175,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
#J-18808-Ljbffr
Apply remote type Onsite locations Cambridge, MA time type Full time posted on Posted 5 Days Ago job requisition id R-02587Why Sarepta? Why Now?The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophies (LGMDs), and we currently have more than 40 programs in various stages of development in gene therapy, RNA and gene editing. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.
We’re looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.
What Sarepta OffersAt Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:Physical and Emotional WellnessFinancial WellnessSupport for CaregiversFor a full list of our comprehensive benefits, see our website:
https://www.sarepta.com/join-us
The Importance of the RoleThe RNA Research group at Sarepta Therapeutics is seeking a talented, motivated, and experienced scientist to join the dynamic and fast-paced chemistry team located in Cambridge, MA. The successful candidate will work on our PMO oligonucleotide platform and discovery research on improved delivery of oligonucleotides as well as manage collaborations and CROs as needed. This position will work closely with Discovery Biology, Translational Sciences, Business Development and Legal teams to implement new drug discovery programs and advance next generation of RNA therapeutics.The Opportunity to Make a DifferenceDesign and conduct novel oligonucleotide conjugates synthesis, purification, and characterization; Apply state-of-the-art delivery methods to achieve
in vivo
proof of concept; Develop efficient and scalable synthetic methods and routes.Develop and utilize innovative synthetic, medicinal chemistry and/or chemical biology problem solving skills coupled with analysis of diverse data sets to build structure-activity relationships.Act as key member of a multidisciplinary RNA research team, assisting with development of project strategy, and analysis and communication of complex data.Serves as an in-house oligonucleotide and delivery chemistry expert.Drive the writing of technical reports to support patent applications and manuscript preparations.Coordinate and manage collaborations and CRO operations to ensure deliverables meet project needs.Organize workstreams and complete individual and team objectives to maintain project timelines.Supervise and mentor junior staff.More about YouThe ideal candidate will have a PhD with 8+ years in organic chemistry, biochemistry, or related fields industry experience; or M.S. with 12+ years of experience.Strong experience in organic chemistry and multi-step organic synthesis is a must; Hands-on experience with manual and automated systems for solid-phase synthesis of peptides and nucleic acids is essential for this role.Previous experience in the design, chemical optimization, and formulation/delivery of peptides and/or oligonucleotide therapeutics is highly desirable.Experience with using analytical techniques/instrumentation for peptides and/or oligonucleotides purification and characterization such as Reverse Phase (HPLC/UPLC), MALDI-TOF and Liquid Chromatography Mass Spectrometry (LC-MS) is a plus.Track record with the ability to execute multiple concurrent research projects within a cross-functional team environment.Solid written and oral communication skills, enthusiasm, integrity, self-motivation, strong interpersonal skills, and attention to detail are necessary.What Now?We’re always looking for solution-oriented, critical thinkers.So, if you’re comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.
This position requires work on site at one of Sarepta’s facilities in the United States. The targeted salary range for this position is $140,000 - $175,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta’s compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
#J-18808-Ljbffr