Principal Scientist, CMC Antibody Development, Biologics

Who We Are:At Neurocrine Biosciences, we pride ourselves on having a strong, inclusive, and positive culture based on our shared purpose and values. We know what it takes to be great, and we are as passionate about our people as we are about our purpose - to relieve suffering for people with great needs, but few options.What We Do:Neurocrine Biosciences is a leading neuroscience-focused, biopharmaceutical company with a simple purpose: to relieve suffering for people with great needs, but few options. We are dedicated to discovering and developing life-changing treatments for patients with under-addressed neurological, neuroendocrine, and neuropsychiatric disorders. The company's diverse portfolio includes FDA-approved treatments for tardive dyskinesia, chorea associated with Huntington's disease, endometriosis, and uterine fibroids, as well as a robust pipeline including multiple compounds in mid- to late-phase clinical development across our core therapeutic areas.About the Role:Plays a key role in developing our in vitro and in vivo strategies towards target identification and drug discovery, through to clinical candidate selection. May work and be responsible for conceptualization, initiation, and management of gene therapy programs, and support our existing preclinical stage Biologics programs. Works closely with the Research and Development Teams to design and develop drugs utilizing multiple modalities, and train team members to ensure that methods and data analysis are applied appropriately.Your Contributions (include, but are not limited to):Initiates, directs and executes pre-clinical scientific research and/or development strategies in research and/or development.Design and build innovative in vitro & in vivo approaches to screening drug candidates, both internally and through CRO and academic collaborations.Utilize subject-matter expertise and past-experience to influence the direction of research projects including new target due diligence.Work closely with translational biology / biomarker teams.Maintains broad knowledge of state-of-the-art principles and theories.Makes major contributions to scientific literature and conferences.May act as spokesperson on corporate research and development and advise top management.May participate in development of patent applications.Interfaces with various departments and serves as internal consultant.Biologics specific work will include work on Gene Therapy/mAb/peptide projects from inception to IND-enabling studies.Works with internal colleagues and external collaborators across all disciplines of R&D to select targets and develop Biologics products.Works with the R&D team to design and implement a robust strategy for the growth of the Biologics drug development.Design in vitro and in vivo strategies for development of Biologics and conduct and/or manage in vitro and in vivo studies to measure potency and efficacy.Monitors the latest developments in the Biologics Therapy space for opportunities to in-license or acquire technologies.Prepares detailed data reports and present results to peers, colleagues, and collaborators.Presents data as appropriate at scientific meetings at the National and International level.Ability to deliver drug substance to clinical trials and beyond through the transition period from research to development.Other duties as assigned.Requirements:BS/BA degree and 8+ years of experience in the biotech/pharmaceutical industry identifying and developing cell-based disease models capable of miniaturization for drug screening purposes.Experience with primary neurons and iPSC-derived neurons, and their use in assay development, is beneficial.Experience assessing the pharmacological efficacy and MOA of small molecule drug candidates.Master's degree in biology, life sciences or related discipline and 6+ years of experience in the biotech/pharmaceutical industry identifying and developing cell-based disease models capable of miniaturization for drug screening purposes.PhD or equivalent and 4+ years of relevant experience; may include postdoc experience, Gene Therapy positions will require a PhD in Pharmacology, Neuroscience, Endocrinology, Physiology, or closely related discipline.Gene Therapy position will require a minimum of 4 years of experience in the biopharmaceutical industry.Advanced tissue culture techniques, protein expression and purification and analysis.Working knowledge of NGS (next generation sequencing) technologies, their implementation, and data analysis & relevant statistical tests.Gene manipulation techniques, including cloning, and use of gene expression manipulation technologies (ASO, siRNA, miRNA, AAV transduction).Tissue handling techniques for detection of gene and protein expression, including fixation, sectioning, IHC, histological staining, ISH.Knowledge of protein structure function relationships.Ability to utilize bioinformatics software for protein and gene analyses.Proven strong track record in advanced experimental technologies and their utilization in the drug discovery process.Excellent critical analysis skills.Assimilates data and research findings outside of Neurocrine for application to new scientific projects.Maintains broad knowledge of scientific principles and theories and possesses intellectual mastery of one or more scientific areas.Ability to work as part of and lead multiple teams.Exhibits leadership skill and ability, typically leads lower levels and/or indirect teams.Excellent computer skills.Excellent communications, problem-solving, analytical thinking skills.Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency.Excellent project management skills.#LI-AD1Neurocrine Biosciences is an EEO/AA/Disability/Vets employer. We are committed to building a diverse, equitable, and inclusive workplace, and we recognize there are a variety of ways to meet our requirements. We are looking for the best candidate for the job and encourage you to apply even if your experience or qualifications don't line up to exactly what we have outlined in the job description.

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