Bristol Myers Squibb
Principal Scientist Molecular Interactions and Analytics
Bristol Myers Squibb, Redwood City, California, United States, 94061
Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.
The Molecular Interactions and Analytics Group is seeking a skilled and enthusiastic Principal Scientist to support our biophysical characterization of drug candidates by providing quantitative data and deep biophysical understanding to drive decisions in a highly collaborative environment. The candidate will report to the team lead to help discover novel therapeutic antibodies. This high-level scientific position is laboratory focused. You will represent the Molecular Interactions function at discovery team meetings for multiple oncology projects, where you contribute with your biophysical expertise for selecting and optimizing therapeutic antibodies.
The primary responsibility of the role is to support our biophysical binding characterization of unpurified and purified antibody candidates. Responsibilities include:
Perform and analyze kinetic and thermodynamic studies of antigen-antibody interactions using surface plasmon resonance (SPR) with sufficient rigor to both evaluate and characterize the antigen-antibody interactions under study.Perform epitope binning studies using SPR.Perform and analyze kinetic and thermodynamic studies of antigen-antibody interactions using solution-based methods such as Kinetic Exclusion Assay or non-traditional SPR experiments.Drive the development of novel biophysical assays.Contribute as an essential and reliable component to help drive projects to a successful conclusion with a high level of motivation.Interact productively with scientifically diverse research teams, including clear and concise presentation of data through oral presentations and written reports/communications.Use professional concepts to contribute to the development of the company's professional and scientific concepts and principles to achieve objectives in creative and effective ways.
Basic Qualifications:Bachelor's Degree with 8+ years of academic/industry experienceor Master's Degree with 6+ years of academic/industry experienceor PhD with 4+ years of academic/industry experience
Preferred Qualifications:Position requires a background in Biophysics, Chemistry, Biochemistry or related field with a Ph.D. and 4+ more years of professional experience, or a master's degree with 6+ years or greater of relevant experience in a pharmaceutical or biotechnology research environment.Knowledge of surface plasmon resonance and experience with the operation of diverse SPR instrumentation.Knowledge of KinExA experiments and experience with the operation of KinExA instrumentation a plus.Demonstrated ability to interpret biophysical binding data.Demonstrated ability to communicate and present biophysical binding data to scientifically diverse teams.Demonstrated ability to creatively solve problems related to biophysical experimental design.Knowledge and understanding of the application of statistical principles and statistical software (e.g. GraphPad) required.Must be highly self-motivated, detail-oriented and well organized.Has the ability and desire to work in a team-oriented environment.Experience and knowledge of flow cytometric antibody binding screens not required but a plus.Experience with Octet BLI instrumentation a plus.Experience with early stage antibody stability assays a plus.
Compensation:The starting compensation for this job is a range from $121,000 - $167,200 plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits:Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.
Uniquely Interesting Work, Life-changing Careers:With a single vision as inspiring as Transforming patients' lives through science, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol:BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility.Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture.For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.#J-18808-Ljbffr
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as bispecific antibodies, antibody drug conjugates and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.
The Molecular Interactions and Analytics Group is seeking a skilled and enthusiastic Principal Scientist to support our biophysical characterization of drug candidates by providing quantitative data and deep biophysical understanding to drive decisions in a highly collaborative environment. The candidate will report to the team lead to help discover novel therapeutic antibodies. This high-level scientific position is laboratory focused. You will represent the Molecular Interactions function at discovery team meetings for multiple oncology projects, where you contribute with your biophysical expertise for selecting and optimizing therapeutic antibodies.
The primary responsibility of the role is to support our biophysical binding characterization of unpurified and purified antibody candidates. Responsibilities include:
Perform and analyze kinetic and thermodynamic studies of antigen-antibody interactions using surface plasmon resonance (SPR) with sufficient rigor to both evaluate and characterize the antigen-antibody interactions under study.Perform epitope binning studies using SPR.Perform and analyze kinetic and thermodynamic studies of antigen-antibody interactions using solution-based methods such as Kinetic Exclusion Assay or non-traditional SPR experiments.Drive the development of novel biophysical assays.Contribute as an essential and reliable component to help drive projects to a successful conclusion with a high level of motivation.Interact productively with scientifically diverse research teams, including clear and concise presentation of data through oral presentations and written reports/communications.Use professional concepts to contribute to the development of the company's professional and scientific concepts and principles to achieve objectives in creative and effective ways.
Basic Qualifications:Bachelor's Degree with 8+ years of academic/industry experienceor Master's Degree with 6+ years of academic/industry experienceor PhD with 4+ years of academic/industry experience
Preferred Qualifications:Position requires a background in Biophysics, Chemistry, Biochemistry or related field with a Ph.D. and 4+ more years of professional experience, or a master's degree with 6+ years or greater of relevant experience in a pharmaceutical or biotechnology research environment.Knowledge of surface plasmon resonance and experience with the operation of diverse SPR instrumentation.Knowledge of KinExA experiments and experience with the operation of KinExA instrumentation a plus.Demonstrated ability to interpret biophysical binding data.Demonstrated ability to communicate and present biophysical binding data to scientifically diverse teams.Demonstrated ability to creatively solve problems related to biophysical experimental design.Knowledge and understanding of the application of statistical principles and statistical software (e.g. GraphPad) required.Must be highly self-motivated, detail-oriented and well organized.Has the ability and desire to work in a team-oriented environment.Experience and knowledge of flow cytometric antibody binding screens not required but a plus.Experience with Octet BLI instrumentation a plus.Experience with early stage antibody stability assays a plus.
Compensation:The starting compensation for this job is a range from $121,000 - $167,200 plus incentive cash and stock opportunities (based on eligibility). The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.
Eligibility for specific benefits:Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown days between Christmas and New Year's holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.
Uniquely Interesting Work, Life-changing Careers:With a single vision as inspiring as Transforming patients' lives through science, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
On-site Protocol:BMS has a diverse occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:
Site-essential roles require 100% of shifts onsite at your assigned facility.Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture.For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.
BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.
BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.
If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/
Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.#J-18808-Ljbffr