GlaxoSmithKline
Associate Director, Flow Cytometry
GlaxoSmithKline, Collegeville, Pennsylvania, United States, 19426
Site Name:
USA - Pennsylvania - Upper ProvidencePosted Date:
Sep 12 2024We are looking for a highly motivated, agile and experienced immunologist to join the Cellular Biomarkers Flow Cytometry team within Biomarker & Bioanalytical Platforms in the Precision Medicine department located in Upper Providence, US. Our group is responsible for developing and validating complex multi-parameter biomarker assays for use in clinical studies. We generate deep immunophenotyping data to evaluate disease heterogeneity, drug-target engagement, drug mechanism of action and patient responses. The successful candidate will have a deep understanding of immunology and will act as a flow cytometry technical expert, supporting high parameter deep immunophenotyping of immune cell subsets as well as receptor occupancy endpoints.In this role you will:Provide scientific leadership and guide the development and validation of various high parameter spectral (Cytek Aurora) flow cytometry assays including deep immunophenotyping of immune cell subsets and receptor occupancy endpoints.Oversee all aspects of method development, troubleshooting, validation and sample analysis for clinical studies with flow cytometry endpoints.Guide team in successful interactions with CRO partners to assist in the delivery of high-quality clinical flow cytometry endpoints.Provide biomarker/translational expertise on multiple clinical programs/projects including influencing biomarker strategy.Be responsible for delivery of robust, high quality data packages. Ensure all work is conducted in compliance with GCLP regulations and follow the appropriate SOPs.This role may have the opportunity to manage a small team.Basic Qualifications:We are looking for professionals with these required skills to achieve our goals:PhD in immunology, cell biology or similar with at least five years of post-PhD experience in immunology, cell biology, biomedical science or related disciplines.Five or more years of laboratory experience and understanding of clinical and non-clinical flow cytometry biomarker assay development, validation, and implementation.Five or more years of theoretical and practical understanding of flow cytometry with experience in the design and execution of 16+ colour flow cytometry panels.Preferred Qualifications & Skills:If you have the following characteristics, it would be a plus:Considerable experience in the use of flow cytometry analysis software (OMIQ an advantage).Immunological knowledge covering phenotyping of multiple lineages of cells. Expertise working with a variety of sample types including whole blood, PBMC, cell lines and single-cell suspension from tissue samples.Strong industry experience with excellent collaboration and interpersonal skills to influence biomarker testing strategies and communicate efficiently with colleagues from all phases of clinical drug development.Ability to maintain a disciplined approach, ensuring a relentless focus on quality, compliance, scientific rigor, and operational excellence. Ability to problem solve and troubleshoot.Demonstrated judgment and decision making, especially for prioritizing multiple requests.Experience to design and execute 25+ colour flow cytometry panels. Hands on experience with the Cytek Aurora.Hands on experience with OMIQ.Proactively demonstrate the ability to work to tight deadlines.Please visit
GSK US Benefits Summary
to learn more about the comprehensive benefits program GSK offers US employees.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.Important notice to Employment businesses/AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting
For the Record
site.
#J-18808-Ljbffr
USA - Pennsylvania - Upper ProvidencePosted Date:
Sep 12 2024We are looking for a highly motivated, agile and experienced immunologist to join the Cellular Biomarkers Flow Cytometry team within Biomarker & Bioanalytical Platforms in the Precision Medicine department located in Upper Providence, US. Our group is responsible for developing and validating complex multi-parameter biomarker assays for use in clinical studies. We generate deep immunophenotyping data to evaluate disease heterogeneity, drug-target engagement, drug mechanism of action and patient responses. The successful candidate will have a deep understanding of immunology and will act as a flow cytometry technical expert, supporting high parameter deep immunophenotyping of immune cell subsets as well as receptor occupancy endpoints.In this role you will:Provide scientific leadership and guide the development and validation of various high parameter spectral (Cytek Aurora) flow cytometry assays including deep immunophenotyping of immune cell subsets and receptor occupancy endpoints.Oversee all aspects of method development, troubleshooting, validation and sample analysis for clinical studies with flow cytometry endpoints.Guide team in successful interactions with CRO partners to assist in the delivery of high-quality clinical flow cytometry endpoints.Provide biomarker/translational expertise on multiple clinical programs/projects including influencing biomarker strategy.Be responsible for delivery of robust, high quality data packages. Ensure all work is conducted in compliance with GCLP regulations and follow the appropriate SOPs.This role may have the opportunity to manage a small team.Basic Qualifications:We are looking for professionals with these required skills to achieve our goals:PhD in immunology, cell biology or similar with at least five years of post-PhD experience in immunology, cell biology, biomedical science or related disciplines.Five or more years of laboratory experience and understanding of clinical and non-clinical flow cytometry biomarker assay development, validation, and implementation.Five or more years of theoretical and practical understanding of flow cytometry with experience in the design and execution of 16+ colour flow cytometry panels.Preferred Qualifications & Skills:If you have the following characteristics, it would be a plus:Considerable experience in the use of flow cytometry analysis software (OMIQ an advantage).Immunological knowledge covering phenotyping of multiple lineages of cells. Expertise working with a variety of sample types including whole blood, PBMC, cell lines and single-cell suspension from tissue samples.Strong industry experience with excellent collaboration and interpersonal skills to influence biomarker testing strategies and communicate efficiently with colleagues from all phases of clinical drug development.Ability to maintain a disciplined approach, ensuring a relentless focus on quality, compliance, scientific rigor, and operational excellence. Ability to problem solve and troubleshoot.Demonstrated judgment and decision making, especially for prioritizing multiple requests.Experience to design and execute 25+ colour flow cytometry panels. Hands on experience with the Cytek Aurora.Hands on experience with OMIQ.Proactively demonstrate the ability to work to tight deadlines.Please visit
GSK US Benefits Summary
to learn more about the comprehensive benefits program GSK offers US employees.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.Important notice to Employment businesses/AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting
For the Record
site.
#J-18808-Ljbffr