Wave Life Sciences
Principal Scientist, Bioanalytical Development
Wave Life Sciences, Lexington, Massachusetts, United States, 02173
Wave Life Sciences is a biotechnology company focused on unlocking the broad potential of RNA medicines to transform human health. Our RNA medicines platform, PRISM, combines multiple modalities, chemistry innovation and deep insights in human genetics to deliver scientific breakthroughs that treat both rare and prevalent disorders. Our toolkit of RNA-targeting modalities includes editing, splicing, RNA interference and antisense silencing, providing us with unmatched capabilities for designing and sustainably delivering candidates that optimally address disease biology. Our diversified pipeline includes clinical programs in Duchenne muscular dystrophy, Alpha-1 antitrypsin deficiency and Huntington’s disease, as well as a preclinical program in obesity. Driven by the calling to “Reimagine Possible”, we are leading the charge toward a world in which human potential is no longer hindered by the burden of disease.
Description
The Principal Scientist, Bioanalytical Development provides technical/scientific leadership within the bioanalytical and biomarker development group (BBD/PCDS) and serves as department representative through the following actions, as it pertains to programs at Wave:
Represents functional area at project team meetings and other development meetings.
Identifies and resolves technical project issues.
Presents issues and solutions for functional area.
Directs technical activity encompassing several aspects of a project or multiple projects, both within Wave Life Sciences and exterior CROs.
Experience
PhD in nucleic acid chemistry, chemistry, biochemistry, or a related scientific field with at least 12-15 years of experience in the biotech/pharmaceutical industry or a BS/MS degree with at least 15 years of relevant industry experience.
Strong hands-on ligand binding assay (ELISA/MSD/Single Molecule Array/Counting tools) and the ability to independently develop, implement, troubleshoot, and execute bioanalytical assays.
Experience on LC/MS instruments is preferred.
Previous experience in managing and/or working with bioanalytical CROs is required.
Experience within a start-up or small biotech environment.
Responsibilities
Actively participate in planning, experimental design and execution of all aspects of bioanalysis including efficient assay development, and creative problem solving.
Serve as a subject matter expert and lead bioanalytical and biomarker responsibilities at program team level.
Ability to take on projects of diverse nature to support internal programs.
Analyze and interpret data from pharmacology studies.
Biochemical and bioanalytical assay development involving a range of tools and techniques such as ELISA and qPCR.
Manage external contract research organization (CRO) relationship to enable the implementation of bioanalytical assays and actively participate in meetings as appropriate.
Capacity to be highly productive in a fluid, fast-paced, innovative work environment.
Key Skills
Demonstrated experience with the development of a broad range of bioanalytical methodologies for characterization of oligonucleotides.
Knowledge of GLP requirements and ICH guidelines desirable.
Must be organized, detail focused, highly collaborative, and possess excellent communication skills.
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Description
The Principal Scientist, Bioanalytical Development provides technical/scientific leadership within the bioanalytical and biomarker development group (BBD/PCDS) and serves as department representative through the following actions, as it pertains to programs at Wave:
Represents functional area at project team meetings and other development meetings.
Identifies and resolves technical project issues.
Presents issues and solutions for functional area.
Directs technical activity encompassing several aspects of a project or multiple projects, both within Wave Life Sciences and exterior CROs.
Experience
PhD in nucleic acid chemistry, chemistry, biochemistry, or a related scientific field with at least 12-15 years of experience in the biotech/pharmaceutical industry or a BS/MS degree with at least 15 years of relevant industry experience.
Strong hands-on ligand binding assay (ELISA/MSD/Single Molecule Array/Counting tools) and the ability to independently develop, implement, troubleshoot, and execute bioanalytical assays.
Experience on LC/MS instruments is preferred.
Previous experience in managing and/or working with bioanalytical CROs is required.
Experience within a start-up or small biotech environment.
Responsibilities
Actively participate in planning, experimental design and execution of all aspects of bioanalysis including efficient assay development, and creative problem solving.
Serve as a subject matter expert and lead bioanalytical and biomarker responsibilities at program team level.
Ability to take on projects of diverse nature to support internal programs.
Analyze and interpret data from pharmacology studies.
Biochemical and bioanalytical assay development involving a range of tools and techniques such as ELISA and qPCR.
Manage external contract research organization (CRO) relationship to enable the implementation of bioanalytical assays and actively participate in meetings as appropriate.
Capacity to be highly productive in a fluid, fast-paced, innovative work environment.
Key Skills
Demonstrated experience with the development of a broad range of bioanalytical methodologies for characterization of oligonucleotides.
Knowledge of GLP requirements and ICH guidelines desirable.
Must be organized, detail focused, highly collaborative, and possess excellent communication skills.
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