Tbwa Chiat/Day Inc
Scientist I, Bioanalytical Somerville, Massachusetts, United States
Tbwa Chiat/Day Inc, Somerville, Massachusetts, us, 02145
Somerville, Massachusetts, United StatesMinimum Qualifications:
PhD + 0-2 years or MS + 6 years of industry experience in Chemistry or related discipline e.g., biochemistry, biotechnology or pharmaceutical science. Post-doc experience a plus.In-depth scientific knowledge and hands-on technical expertise on LC-MS, LC-MS/MS, and chromatography methodologies and instrumentation.Experience in high-resolution mass spectrometric bioanalysis of oligonucleotides.Ability to work in a team-oriented environment and conduct multiple laboratory and project tasks efficiently.RNA extraction from in vivo samples such as blood or tissue and downstream statistical bioinformatics analyses (not required experience, but a plus!).You are interested in…
Developing LC-MS methods for characterization and quantitation of oligonucleotides in various biological matrices including biofluids, tissues, cells, and subcellular fractions.Conducting metabolite identification experiments, analyzing, and interpreting data to understand oligonucleotide metabolism.Designing and executing experiments from sample preparation, LC-MS/MS operation to data analysis & interpretation.Coordinating method transfer to CRO and serving as technical expert for method troubleshooting.Writing method protocols and sample analysis procedures. Preparing bioanalytical, metabolite identification reports and data presentations.Providing maintenance, quality control and troubleshooting of high-resolution mass spectrometer and UPLC systems.About you:
You are a scientist who is interested in developing and employing LC-MS methods to characterize and quantitate oligonucleotides. Your background may combine RNA therapeutics with biochemistry methods, LC-MS and proteomics or large molecule bioanalyses. You may also have experience in method qualification and bioanalyses to support pre-clinical studies from experience working with small molecule LC-MS and bioanalyses for small molecule drugs. You have excellent communication skills and can work in a dynamic and fast-paced work environment to support research, non-clinical and clinical development programs for various therapeutic indications.Tessera employees are creative and collaborative problem solvers. They have a strong sense of integrity and unwavering commitment to scientific excellence.Meet your Manager:
All inquiries regarding the posted position should be directed to the Talent Partner (see below). Interested individuals must apply directly to be considered for the opening.Tessera offers a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits currently include group medical, vision and dental coverage, group life and disability insurance, 401(k) with company contribution, tuition reimbursement, and much more.Company Summary:
Tessera Therapeutics is pioneering Gene Writing—a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy.More about Tessera Therapeutics:Tessera is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate.
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PhD + 0-2 years or MS + 6 years of industry experience in Chemistry or related discipline e.g., biochemistry, biotechnology or pharmaceutical science. Post-doc experience a plus.In-depth scientific knowledge and hands-on technical expertise on LC-MS, LC-MS/MS, and chromatography methodologies and instrumentation.Experience in high-resolution mass spectrometric bioanalysis of oligonucleotides.Ability to work in a team-oriented environment and conduct multiple laboratory and project tasks efficiently.RNA extraction from in vivo samples such as blood or tissue and downstream statistical bioinformatics analyses (not required experience, but a plus!).You are interested in…
Developing LC-MS methods for characterization and quantitation of oligonucleotides in various biological matrices including biofluids, tissues, cells, and subcellular fractions.Conducting metabolite identification experiments, analyzing, and interpreting data to understand oligonucleotide metabolism.Designing and executing experiments from sample preparation, LC-MS/MS operation to data analysis & interpretation.Coordinating method transfer to CRO and serving as technical expert for method troubleshooting.Writing method protocols and sample analysis procedures. Preparing bioanalytical, metabolite identification reports and data presentations.Providing maintenance, quality control and troubleshooting of high-resolution mass spectrometer and UPLC systems.About you:
You are a scientist who is interested in developing and employing LC-MS methods to characterize and quantitate oligonucleotides. Your background may combine RNA therapeutics with biochemistry methods, LC-MS and proteomics or large molecule bioanalyses. You may also have experience in method qualification and bioanalyses to support pre-clinical studies from experience working with small molecule LC-MS and bioanalyses for small molecule drugs. You have excellent communication skills and can work in a dynamic and fast-paced work environment to support research, non-clinical and clinical development programs for various therapeutic indications.Tessera employees are creative and collaborative problem solvers. They have a strong sense of integrity and unwavering commitment to scientific excellence.Meet your Manager:
All inquiries regarding the posted position should be directed to the Talent Partner (see below). Interested individuals must apply directly to be considered for the opening.Tessera offers a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits currently include group medical, vision and dental coverage, group life and disability insurance, 401(k) with company contribution, tuition reimbursement, and much more.Company Summary:
Tessera Therapeutics is pioneering Gene Writing—a new biotechnology designed to offer scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy.More about Tessera Therapeutics:Tessera is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate.
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