Flagship Pioneering
Quotient Therapeutics, Inc. | Cambridge, MA Associate Director/Director, Precisi
Flagship Pioneering, Cambridge, Massachusetts, us, 02140
Associate Director/Director, Precision Oncology
Cambridge, MA USAWhat if…
you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?Flagship Pioneering's venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Sana Biotechnology (NASDAQ: SANA), Generate Biomedicines, and Tessera Therapeutics. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $212 billion in aggregate value.The Company:Quotient Therapeutics, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.Position Summary:Quotient Tx is seeking a talented and highly motivated Associate Director/Director Oncology to play a vital role in the company’s efforts to progress lead candidates to IND and early clinical studies. The candidate will be responsible for the translational validation of discovery platform targets in cell-based and disease-relevant pharmacological models. This role requires a dynamic leader capable of designing, planning, and implementing high-quality in vitro and in vivo assays, and will be pivotal in advancing our precision oncology research programs.Key Responsibilities:Experimental Design and Implementation:
Work independently and collaboratively with a team to design, plan, and implement high-quality in vitro and in vivo assays.Target Validation Leadership:
Lead target validation activities, including target assessment, prioritization, and the development and execution of workplans.Mechanism of Action Studies:
Design and implement in vitro assays to evaluate the mechanisms of action of the target. This includes thorough assessment and validation in disease-relevant models.Animal Studies Coordination:
Plan and execute animal studies by coordinating with external research vendors, defining tissue and disease-specific target engagement levels, and establishing biomarker plans and translational PK/PD assessments.Project Oversight:
Lead cross-functional project teams to design, plan, and execute experimental studies, ensuring milestones and objectives are met within established timelines. Collaborate with drug design, pharmacology, and translational research teams to advance candidate molecules through the drug discovery pipeline.Team Leadership:
Ensure the timely delivery of key team deliverables and mentor and train junior scientists within the group as needed.Data Analysis and Communication:
Communicate findings effectively through written and oral presentations.Qualifications:Educational Background:
Ph.D. in Cancer Biology, Immunology, or a related discipline with 8 - 10 years of experience in a biotech or pharmaceutical company.Subject Matter Expertise:
Comprehensive knowledge and understanding of tumor intrinsic mechanisms and target validation for drug discovery.Technical Skills:
Extensive hands-on experience in mammalian cell culture and proficiency in designing and executing tumor animal models.Leadership Experience:
Proven experience in directly supervising and mentoring scientists and research associates.Communication Skills:
Outstanding written and oral presentation skills.Personal Attributes:
Highly motivated, results-oriented, and team-focused individual.Preferred Attributes:Industry Experience:
Previous experience in the biotechnology or pharmaceutical industry, with a focus on precision oncology research.Advanced Assay Development:
Experience in developing and implementing advanced cell-culture assays in Oncology.Location:
Cambridge, MAAbout Flagship:Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability.Flagship Pioneering and our ecosystem companies are
committed to equal employment opportunity
regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway.
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Cambridge, MA USAWhat if…
you could join an organization that creates, resources, and builds life sciences companies that invent breakthrough technologies to transform human health and sustainability?Flagship Pioneering's venture creation engine has conceived and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Sana Biotechnology (NASDAQ: SANA), Generate Biomedicines, and Tessera Therapeutics. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures, resulting in over $212 billion in aggregate value.The Company:Quotient Therapeutics, Inc. is a privately held, early-stage company developing a novel genomics platform and therapeutics for diseases with a large unmet need.Position Summary:Quotient Tx is seeking a talented and highly motivated Associate Director/Director Oncology to play a vital role in the company’s efforts to progress lead candidates to IND and early clinical studies. The candidate will be responsible for the translational validation of discovery platform targets in cell-based and disease-relevant pharmacological models. This role requires a dynamic leader capable of designing, planning, and implementing high-quality in vitro and in vivo assays, and will be pivotal in advancing our precision oncology research programs.Key Responsibilities:Experimental Design and Implementation:
Work independently and collaboratively with a team to design, plan, and implement high-quality in vitro and in vivo assays.Target Validation Leadership:
Lead target validation activities, including target assessment, prioritization, and the development and execution of workplans.Mechanism of Action Studies:
Design and implement in vitro assays to evaluate the mechanisms of action of the target. This includes thorough assessment and validation in disease-relevant models.Animal Studies Coordination:
Plan and execute animal studies by coordinating with external research vendors, defining tissue and disease-specific target engagement levels, and establishing biomarker plans and translational PK/PD assessments.Project Oversight:
Lead cross-functional project teams to design, plan, and execute experimental studies, ensuring milestones and objectives are met within established timelines. Collaborate with drug design, pharmacology, and translational research teams to advance candidate molecules through the drug discovery pipeline.Team Leadership:
Ensure the timely delivery of key team deliverables and mentor and train junior scientists within the group as needed.Data Analysis and Communication:
Communicate findings effectively through written and oral presentations.Qualifications:Educational Background:
Ph.D. in Cancer Biology, Immunology, or a related discipline with 8 - 10 years of experience in a biotech or pharmaceutical company.Subject Matter Expertise:
Comprehensive knowledge and understanding of tumor intrinsic mechanisms and target validation for drug discovery.Technical Skills:
Extensive hands-on experience in mammalian cell culture and proficiency in designing and executing tumor animal models.Leadership Experience:
Proven experience in directly supervising and mentoring scientists and research associates.Communication Skills:
Outstanding written and oral presentation skills.Personal Attributes:
Highly motivated, results-oriented, and team-focused individual.Preferred Attributes:Industry Experience:
Previous experience in the biotechnology or pharmaceutical industry, with a focus on precision oncology research.Advanced Assay Development:
Experience in developing and implementing advanced cell-culture assays in Oncology.Location:
Cambridge, MAAbout Flagship:Flagship Pioneering is a bioplatform innovation company that invents and builds platform companies, each with the potential for multiple products that transform human health or sustainability.Flagship Pioneering and our ecosystem companies are
committed to equal employment opportunity
regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway.
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