Vor Bio
Associate Director / Director, Process Development
Vor Bio, Cambridge, Massachusetts, us, 02140
We engineer stem cell transplants that shield healthy cells from targeted therapies
Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.
At Vor Bio, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.
These eHSCs give rise to generations of new healthy blood cells that are effectively shielded from targeted therapies so that only the remaining cancer cells are killed. We are also developing our own CAR-T cell therapy using T cells from the same healthy donor who could potentially provide HSCs for our shielded stem cell transplant and thereby, avoid issues of donor-mismatch. We believe our CAR-T cell therapy may enable more potent and durable responses post-transplant.
Vor Bio is aiming to cure blood cancers through our novel platform combining HSC biology, genome engineering, and targeted therapies to unlock treatment options previously unavailable to patients. Come be a part of a passionate team striving to collaboratively develop a groundbreaking approach to cancer treatment, one of medicine's greatest challenges.
What we value in our fellow Voracians
Passion:
Enthusiastically driving our science toward innovative medicines
Fellowship:
Fostering genuine bonds of collaboration and mentorship
Humility:
Acting selflessly by putting the collective mission first
Who we are looking for:
Vor Bio is seeking an Associate Director/Director of Process Development who will be a key member of the Process and Analytical Development group. The successful candidate will oversee the design, development, and characterization of gene edited hematopoietic stem cells (eHSC) and CAR-T manufacturing processes to support early and late phase clinical trials. The successful candidate will have a broad understanding of cell therapy manufacturing and familiarity with manufacturing of critical/ancillary reagents. The ideal candidate will possess significant experience and skills in people/project management and cross-functional collaboration.
Key areas of responsibility:
Oversee all aspects of Process Design for HSCs and CAR-T: optimize cell therapy manufacturing process, execute process characterization, author process control strategy, and support process validation
As necessary, provide support for the development, characterization, comparability, and validation of critical starting material manufacturing processes, e.g., Cas9, gRNA, and lentiviral vector production
Establish strong collaborative relationships and represent Process Development function across the organization and with external partners
Author and review technical reports, regulatory documents, and patents as necessary
Champion a "protocol-driven" and "report results" methodology
Maintain and foster a positive, supportive, and collaborative team culture
Qualifications:
PhD in the pertinent life sciences or engineering, with 10+ years relevant experience
Excellent cross-functional communication skills
Expertise (5-7+ years) leading process development of HSC and/or CAR-T products
Process development experience in late-stage program is highly desired
Understanding of cGMPs and demonstrated experience leading groups with substantial contributions to regulatory filings
Understanding of manufacturing processes for genome editing reagents including Cas9, gRNA, lentiviral vectors
Demonstrated track record of consistently meeting deadlines in a dynamic, fast-paced environment
Experience in process characterization and validation is a plus
By becoming a team member here at Vor, you'll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work-life balance, you'll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in Cambridge with easy access to public transportation and ample parking.
As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
Please visit our website at
https://www.vorbio.com/
for more information.
#J-18808-Ljbffr
Targeted therapies work by attacking cells that express particular proteins on their surface. Unfortunately, both diseased and healthy cells often express the same proteins, resulting in collateral damage to healthy cells.
At Vor Bio, we engineer hematopoietic stem cells (HSCs) to lack a biologically redundant target protein, then transplant these cells into the patient.
These eHSCs give rise to generations of new healthy blood cells that are effectively shielded from targeted therapies so that only the remaining cancer cells are killed. We are also developing our own CAR-T cell therapy using T cells from the same healthy donor who could potentially provide HSCs for our shielded stem cell transplant and thereby, avoid issues of donor-mismatch. We believe our CAR-T cell therapy may enable more potent and durable responses post-transplant.
Vor Bio is aiming to cure blood cancers through our novel platform combining HSC biology, genome engineering, and targeted therapies to unlock treatment options previously unavailable to patients. Come be a part of a passionate team striving to collaboratively develop a groundbreaking approach to cancer treatment, one of medicine's greatest challenges.
What we value in our fellow Voracians
Passion:
Enthusiastically driving our science toward innovative medicines
Fellowship:
Fostering genuine bonds of collaboration and mentorship
Humility:
Acting selflessly by putting the collective mission first
Who we are looking for:
Vor Bio is seeking an Associate Director/Director of Process Development who will be a key member of the Process and Analytical Development group. The successful candidate will oversee the design, development, and characterization of gene edited hematopoietic stem cells (eHSC) and CAR-T manufacturing processes to support early and late phase clinical trials. The successful candidate will have a broad understanding of cell therapy manufacturing and familiarity with manufacturing of critical/ancillary reagents. The ideal candidate will possess significant experience and skills in people/project management and cross-functional collaboration.
Key areas of responsibility:
Oversee all aspects of Process Design for HSCs and CAR-T: optimize cell therapy manufacturing process, execute process characterization, author process control strategy, and support process validation
As necessary, provide support for the development, characterization, comparability, and validation of critical starting material manufacturing processes, e.g., Cas9, gRNA, and lentiviral vector production
Establish strong collaborative relationships and represent Process Development function across the organization and with external partners
Author and review technical reports, regulatory documents, and patents as necessary
Champion a "protocol-driven" and "report results" methodology
Maintain and foster a positive, supportive, and collaborative team culture
Qualifications:
PhD in the pertinent life sciences or engineering, with 10+ years relevant experience
Excellent cross-functional communication skills
Expertise (5-7+ years) leading process development of HSC and/or CAR-T products
Process development experience in late-stage program is highly desired
Understanding of cGMPs and demonstrated experience leading groups with substantial contributions to regulatory filings
Understanding of manufacturing processes for genome editing reagents including Cas9, gRNA, lentiviral vectors
Demonstrated track record of consistently meeting deadlines in a dynamic, fast-paced environment
Experience in process characterization and validation is a plus
By becoming a team member here at Vor, you'll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work-life balance, you'll benefit from discretionary time off, parental leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. We are conveniently located in Cambridge with easy access to public transportation and ample parking.
As an equal opportunity employer, we at Vor Bio know that diversity inspires innovation, inclusiveness, and creativity. We invite you to come as you are. All applicants will be considered for employment agnostic to race, age, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.
Please visit our website at
https://www.vorbio.com/
for more information.
#J-18808-Ljbffr