Pfizer, S.A. de C.V
Senior Scientist -- Downstream Process Development
Pfizer, S.A. de C.V, Pearl River, New York, United States, 10965
Senior Scientist -- Downstream Process Development
We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.You will contribute to downstream process development for various vaccine programs. You will work closely with the Principal Scientist/Senior Principal Scientist to develop and apply interdisciplinary approaches to improve purification and characterization of the mRNA Drug Substance (DS) for the development of next-generation RNA vaccine candidates. You will regularly contribute at vaccine development meetings and represent the department on multidisciplinary teams. You will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class mRNA-based vaccines to patients around the world.Position ResponsibilitiesLead the multi-step design, planning and execution of analytical strategies, methods and instrumentation to purify and characterize the mRNA Drug Substance (DS).Develop continuous downstream process for drug substance.Mentor junior scientists’ research activities and provide technical guidance when necessary.Collaborate with colleagues and subject matter experts to assess the most appropriate analytical approach to support project activities, including use of computational predictive tools, modelling software and data visualization tools where appropriate.Lead and be responsible for several projects, helping teams devise effective strategies for analytical requirements and controls.Interact with Bioprocess Fermentation, Analytical, and Formulation Development groups to support downstream process development and in-process sample analysis activities.Author relevant sections of vaccine technical report documents in support for interdepartmental technology and method transfer.Prepare technical reports, critically review data, and evaluate new instrumentation and analytical techniques/approaches, as necessary.Independently analyze and provide conclusions regarding experimental data generated.QualificationsMust HavePhD degree in Biochemistry, Analytical Chemistry or related field.Relevant downstream industry or postdoctoral research experience.Extensive hands-on experience and strong background in chromatography and filtration.Experience with bio-process downstream development.Experience with nucleic acid or protein purification and characterization including FPLC, HPLC, UF/DF, UV/Vis, SDS-PAGE, and/or Fragment Analyzer/Tape station.Experience mentoring junior level Scientists.Experience independently designing, planning, and executing purification/recovery activities.Understanding of critical quality attributes of drug substance.Proficient with a wide variety of software and information systems used in downstream process development platforms.Strong technical writing and presentation skills.Nice To HaveExperience with tech transfer to manufacturing site.Experience with continuous processing.Physical/Mental RequirementsAbility to perform complex data analysis.Relocation support available.Work Location Assignment: On Premise.
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We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.You will contribute to downstream process development for various vaccine programs. You will work closely with the Principal Scientist/Senior Principal Scientist to develop and apply interdisciplinary approaches to improve purification and characterization of the mRNA Drug Substance (DS) for the development of next-generation RNA vaccine candidates. You will regularly contribute at vaccine development meetings and represent the department on multidisciplinary teams. You will apply cutting edge design and process development capabilities to accelerate and bring the best-in-class mRNA-based vaccines to patients around the world.Position ResponsibilitiesLead the multi-step design, planning and execution of analytical strategies, methods and instrumentation to purify and characterize the mRNA Drug Substance (DS).Develop continuous downstream process for drug substance.Mentor junior scientists’ research activities and provide technical guidance when necessary.Collaborate with colleagues and subject matter experts to assess the most appropriate analytical approach to support project activities, including use of computational predictive tools, modelling software and data visualization tools where appropriate.Lead and be responsible for several projects, helping teams devise effective strategies for analytical requirements and controls.Interact with Bioprocess Fermentation, Analytical, and Formulation Development groups to support downstream process development and in-process sample analysis activities.Author relevant sections of vaccine technical report documents in support for interdepartmental technology and method transfer.Prepare technical reports, critically review data, and evaluate new instrumentation and analytical techniques/approaches, as necessary.Independently analyze and provide conclusions regarding experimental data generated.QualificationsMust HavePhD degree in Biochemistry, Analytical Chemistry or related field.Relevant downstream industry or postdoctoral research experience.Extensive hands-on experience and strong background in chromatography and filtration.Experience with bio-process downstream development.Experience with nucleic acid or protein purification and characterization including FPLC, HPLC, UF/DF, UV/Vis, SDS-PAGE, and/or Fragment Analyzer/Tape station.Experience mentoring junior level Scientists.Experience independently designing, planning, and executing purification/recovery activities.Understanding of critical quality attributes of drug substance.Proficient with a wide variety of software and information systems used in downstream process development platforms.Strong technical writing and presentation skills.Nice To HaveExperience with tech transfer to manufacturing site.Experience with continuous processing.Physical/Mental RequirementsAbility to perform complex data analysis.Relocation support available.Work Location Assignment: On Premise.
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