Pfizer, S.A. de C.V
Principal Scientist- Downstream Process Development
Pfizer, S.A. de C.V, Pearl River, New York, United States, 10965
Principal Scientist- Downstream Process Development
We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.As a Principal Scientist in Downstream R&D, you will contribute to downstream process development for various vaccine programs. You will work closely with the Senior Principal Scientist/Director to develop and apply interdisciplinary approaches to improve purification and characterization of the mRNA Drug Substance (DS) for the development of next-generation RNA vaccine candidates. You will be recognized as a technical expert and a significant scientific contributor. With your deep knowledge of the discipline, you will regularly contribute at the vaccine development meetings and can represent the department on multidisciplinary teams. You will also undertake mentoring activities to guide team members. With your innovative scientific acumen, you will apply cutting-edge design and process development capabilities to accelerate and bring the best-in-class mRNA-based vaccines to patients around the world.POSITION RESPONSIBILITIESLead the multi-step design, planning and execution of analytical strategies, methods and instrumentation to purify and characterize the mRNA Drug Substance (DS).Develop continuous downstream process for drug substance.Mentor junior scientists’ research activities and provide technical guidance when necessary.Collaborate with colleagues and subject matter experts to assess the most appropriate analytical approach to support project activities, including use of computational predictive tools, modelling software and data visualization tools where appropriate.Through effective leadership, communication and collaboration with multidisciplinary team members, lead and be responsible for several projects, helping teams devise effective strategies for analytical requirements and controls.Collaborate with, mentor peers, and effectively interact with colleagues at all levels of the organization.Author relevant sections of vaccine technical report documents in support for interdepartmental technology and method transfer. Prepare technical reports, critically review data, and may evaluate new instrumentation and analytical techniques/approaches.Proficient with a wide variety of software and information systems and the curiosity and passion to continue learning in a dynamic environment.EDUCATION AND EXPERIENCEPhD degree in Biochemistry, Analytical Chemistry or related field, with at least 2+ years relevant downstream industry experience.Extensive hands-on experience and strong background in chromatography and filtration.Prior experience with bio-process downstream development.Experience with nucleic acid or protein purification and characterization including FPLC, HPLC, UF/DF, UV/Vis, SDS-PAGE, and/or Fragment Analyzer/Tape station.Understanding of critical quality attributes of drug substance.Prior experience with tech transfer to manufacturing site is preferred.Experience with continuous processing is preferred.Exemplary people skills and demonstrable leadership behaviors.Excellent problem-solving skills.Demonstrated technical writing and presentation skills.TECHNICAL SKILLS REQUIREMENTSKnowledge and ability to independently design, plan, and execute purification/recovery activities.Independently analyze and provide conclusions regarding experimental data generated.PHYSICAL/MENTAL REQUIREMENTSConduct all activities and make decisions in accordance with Company policies & SOPs, Pfizer Values, & global regulatory guidelines (including cGMP/cGLP/cGCP), environmental guidelines, as appropriate, etc.Work Location Assignment: On Premise with relocation assistance available.The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share-based long-term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments.
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We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.As a Principal Scientist in Downstream R&D, you will contribute to downstream process development for various vaccine programs. You will work closely with the Senior Principal Scientist/Director to develop and apply interdisciplinary approaches to improve purification and characterization of the mRNA Drug Substance (DS) for the development of next-generation RNA vaccine candidates. You will be recognized as a technical expert and a significant scientific contributor. With your deep knowledge of the discipline, you will regularly contribute at the vaccine development meetings and can represent the department on multidisciplinary teams. You will also undertake mentoring activities to guide team members. With your innovative scientific acumen, you will apply cutting-edge design and process development capabilities to accelerate and bring the best-in-class mRNA-based vaccines to patients around the world.POSITION RESPONSIBILITIESLead the multi-step design, planning and execution of analytical strategies, methods and instrumentation to purify and characterize the mRNA Drug Substance (DS).Develop continuous downstream process for drug substance.Mentor junior scientists’ research activities and provide technical guidance when necessary.Collaborate with colleagues and subject matter experts to assess the most appropriate analytical approach to support project activities, including use of computational predictive tools, modelling software and data visualization tools where appropriate.Through effective leadership, communication and collaboration with multidisciplinary team members, lead and be responsible for several projects, helping teams devise effective strategies for analytical requirements and controls.Collaborate with, mentor peers, and effectively interact with colleagues at all levels of the organization.Author relevant sections of vaccine technical report documents in support for interdepartmental technology and method transfer. Prepare technical reports, critically review data, and may evaluate new instrumentation and analytical techniques/approaches.Proficient with a wide variety of software and information systems and the curiosity and passion to continue learning in a dynamic environment.EDUCATION AND EXPERIENCEPhD degree in Biochemistry, Analytical Chemistry or related field, with at least 2+ years relevant downstream industry experience.Extensive hands-on experience and strong background in chromatography and filtration.Prior experience with bio-process downstream development.Experience with nucleic acid or protein purification and characterization including FPLC, HPLC, UF/DF, UV/Vis, SDS-PAGE, and/or Fragment Analyzer/Tape station.Understanding of critical quality attributes of drug substance.Prior experience with tech transfer to manufacturing site is preferred.Experience with continuous processing is preferred.Exemplary people skills and demonstrable leadership behaviors.Excellent problem-solving skills.Demonstrated technical writing and presentation skills.TECHNICAL SKILLS REQUIREMENTSKnowledge and ability to independently design, plan, and execute purification/recovery activities.Independently analyze and provide conclusions regarding experimental data generated.PHYSICAL/MENTAL REQUIREMENTSConduct all activities and make decisions in accordance with Company policies & SOPs, Pfizer Values, & global regulatory guidelines (including cGMP/cGLP/cGCP), environmental guidelines, as appropriate, etc.Work Location Assignment: On Premise with relocation assistance available.The annual base salary for this position ranges from $99,900.00 to $166,500.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 15.0% of the base salary and eligibility to participate in our share-based long-term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments.
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