DEM Biopharma
Senior Scientist, Pharmacology/Toxicology – Contractor
DEM Biopharma, Cambridge, Massachusetts, us, 02140
DEM Bio is pioneering the next generation of immunotherapeutics that unleash macrophages and immune phagocytes to eliminate tumors by targeting 'Don't eat me' (DEM) and 'Eat me' (EM) signals on cancer cells and macrophages. Using our proprietary platform, (Co-culture with Human Myeloid Phagocytes) CHoMP, DEM Bio has discovered and validated new DEM and EM signals that could profoundly enhance cancer therapies through increased macrophage-mediated cancer cell elimination. The CHoMP platform utilizes CRISPR-based functional genomic screens in cancer cells and/or macrophages.
Founded by Longwood Fund and pioneering scientists Jonathan Weissman PhD, Kipp Weiskopf MD/PhD, and Michael Bassik PhD, DEM Bio raised a $70M Series led by founding investor Longwood Fund and Alta Partners, with additional participation from Insight Partners, Pfizer Ventures, Astellas Venture Management, Emerson Collective, UTokyo Innovation Platform and Alexandria Venture Investments.
The PositionWe are looking for an experienced and motivated scientist to join our pharmacology – toxicology team to drive in vivo target validation and preclinical drug development for biologics and small molecules from lead to IND. Our collaborative and innovative culture favors highly organized candidates, eager to learn and confident to work cross-functionally and with CRO. A successful candidate will be well versed in preclinical pharmacology, including most animal models of cancer, and in the principles of pharmacokinetics and pharmacodynamic evaluation.
Responsibilities
Plan, implement and manage external
in vivo
pharmacology studies to deliver key experimental data in support of preclinical drug development.
Develop innovative disease models tailored to study novel molecular targets
in vivo .
Validate role of new molecular targets in cancer, determine mode of action (MoA) of new therapeutics and identify pharmacodynamic (PD) markers
in vivo .
Review, analyze and report experimental data to program teams.
Manage external collaborations to ensure timely delivery of preclinical data and achievement of project objectives.
Contribute to scientific publications, IND and other regulatory documents.
Work in a highly cross-functional manner with various teams of the research group.
Qualifications
Ph.D. degree in pharmacology/cancer biology or closely related field with at least 3 years' experience or MS/BS with 6-9 years of experience in biopharma industry.
Extensive knowledge of animal models of cancer, including syngeneic, xenograft and orthotopic tumor models; prior experience with humanized mouse models is a plus.
Experience designing and executing efficacy, MoA and PK/PD studies in mouse models.
Prior hands-on experience leading experiments in mouse models of cancer is required.
Familiarity with
ex vivo
sample analysis techniques including flow cytometry, MSD, ELISA, RNAseq, PCR, IHC, etc.
Proven experience managing external collaborations.
Excellent written and communication skills, ability to organize and present scientific data.
Applicants must be authorized to work for ANY employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.
DEM Biopharma is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law. All employment is decided on the basis of qualifications, merit and business need.
DEM Biopharma values the health and safety of all of our team members, and is committed to making our workplace as safe and welcoming as possible. Successful applicants for this position must be fully vaccinated against COVID-19 or have a valid medical or religious exemption from vaccination, as a condition of employment.
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Founded by Longwood Fund and pioneering scientists Jonathan Weissman PhD, Kipp Weiskopf MD/PhD, and Michael Bassik PhD, DEM Bio raised a $70M Series led by founding investor Longwood Fund and Alta Partners, with additional participation from Insight Partners, Pfizer Ventures, Astellas Venture Management, Emerson Collective, UTokyo Innovation Platform and Alexandria Venture Investments.
The PositionWe are looking for an experienced and motivated scientist to join our pharmacology – toxicology team to drive in vivo target validation and preclinical drug development for biologics and small molecules from lead to IND. Our collaborative and innovative culture favors highly organized candidates, eager to learn and confident to work cross-functionally and with CRO. A successful candidate will be well versed in preclinical pharmacology, including most animal models of cancer, and in the principles of pharmacokinetics and pharmacodynamic evaluation.
Responsibilities
Plan, implement and manage external
in vivo
pharmacology studies to deliver key experimental data in support of preclinical drug development.
Develop innovative disease models tailored to study novel molecular targets
in vivo .
Validate role of new molecular targets in cancer, determine mode of action (MoA) of new therapeutics and identify pharmacodynamic (PD) markers
in vivo .
Review, analyze and report experimental data to program teams.
Manage external collaborations to ensure timely delivery of preclinical data and achievement of project objectives.
Contribute to scientific publications, IND and other regulatory documents.
Work in a highly cross-functional manner with various teams of the research group.
Qualifications
Ph.D. degree in pharmacology/cancer biology or closely related field with at least 3 years' experience or MS/BS with 6-9 years of experience in biopharma industry.
Extensive knowledge of animal models of cancer, including syngeneic, xenograft and orthotopic tumor models; prior experience with humanized mouse models is a plus.
Experience designing and executing efficacy, MoA and PK/PD studies in mouse models.
Prior hands-on experience leading experiments in mouse models of cancer is required.
Familiarity with
ex vivo
sample analysis techniques including flow cytometry, MSD, ELISA, RNAseq, PCR, IHC, etc.
Proven experience managing external collaborations.
Excellent written and communication skills, ability to organize and present scientific data.
Applicants must be authorized to work for ANY employer in the U.S. We are unable to sponsor or take over sponsorship of an employment Visa at this time.
DEM Biopharma is proud to be an Equal Opportunity Employer. Our goal is to have a diverse workforce. We do not discriminate on the basis of race, age, color, religion, national origin, gender, sexual orientation, gender identity or expression, veteran status or disability or any other status protected under federal, state or local law. All employment is decided on the basis of qualifications, merit and business need.
DEM Biopharma values the health and safety of all of our team members, and is committed to making our workplace as safe and welcoming as possible. Successful applicants for this position must be fully vaccinated against COVID-19 or have a valid medical or religious exemption from vaccination, as a condition of employment.
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