St. Jude Children's Research Hospital (St. Jude)
Scientist or Lead Researcher (Protein Engineering, Hematology, Shengdar Q. Tsai
St. Jude Children's Research Hospital (St. Jude), Memphis, Tennessee, us, 37544
Apply your expertise in protein engineering towards this unique Scientist or Lead Researcher opportunity in the Tsai Genome Editing Lab, focusing on advancing genome editing technologies towards individualized treatments of pediatric patients with bone marrow failures from bench to bedside.
Overview of our lab. The
Tsai
lab is a highly collaborative, creative, and fun group of scientists at St. Jude Children’s Research Hospital. Our research program centers on: development of state-of-the-art genomic methods for understanding the global activities of genome editors, protein engineering to improve their capabilities for precise editing, and translation to autologous genome edited hematopoietic stem cell therapies.
About the job opportunity.
We are seeking an outstanding and highly motivated Scientist or Lead Researcher to help lead efforts to develop personalized genome editing treatments for bone marrow failure disorders. We care deeply about the success of our scientists and this job is a unique opportunity to learn about genomics, genome editing, and protein engineering while contributing to the development of future individualized genomic medicines at St. Jude, with room for career growth and advancement.
Dr. Tsai
is co-leading a new Blue Sky Project called PARADIGM (Partnership to Advance Development of Individualized Genomic Medicines) with goal of developing personalized genome editing therapies for St. Jude patients.
You would have opportunities to lead exciting projects that include:
Protein engineering of improved novel CRISPR base and prime genome editors with human cell-based directed evolution.
Understanding the structure-function relationship of mutations identified from high-throughput screens on the activity of genome editors.
Perform deep mutational scanning of CRISPR-Cas orthologues and effector domains important for precise genome editing such as deaminases and reverse transcriptases.
Define the outcome of engineered variants on genome editing repair outcomes using high-throughput genomic methods.
Help develop laboratory automation workflows to perform scalable protein engineering.
You would learn valuable laboratory skills that include:
Genome engineering, high-throughput genomics, next-generation sequencing, protein engineering, structural biology, liquid handling automation, hematopoietic stem cell cell culture and transfection, and data science.
Project-dependent responsibilities could include:
Engineer CRISPR base and prime editors with improved activity and specificities.
Test new strategies to edit human hematopoietic stem cells for treatment of bone marrow failure disorders, focused on rapid development of editing strategies for rare patient-specific mutations.
Optimize lead protein candidates by structure-guided design and high-throughput screening.
Apply new machine learning techniques to guide protein engineering design.
Analyze experimental outcomes and develop high-quality summaries towards manuscripts and grant applications.
Draft manuscripts and figures for publication in high-impact journals.
Minimum Education and/or Training for the position include:
A B.S. in a relevant field, such as genomics, molecular and cell biology.
1 year or more of hands-on, research laboratory experience.
Excellent communication, organizational, and presentation skills.
Scientist Minimum Experience:
Seven (7) years of relevant post-degree work experience is required.
Five (5) years of relevant post-degree work experience is required with a Master's degree.
Three (3) years of relevant post-degree work experience is required with a PhD.
Lead Researcher Minimum Experience:
Five (5) years of relevant, post-degree work experience is required.
Two (2) years of relevant post-degree work experience is required with a Master's degree.
No experience is required with a PhD.
Application process
Apply now
to join our talented team!
Please include your resume and a cover letter addressed to Dr. Tsai who will read and review all qualified applications. If you have questions about the position, please don’t hesitate to e-mail Dr. Tsai directly ( shengdar.tsai@stjude.org ).
#J-18808-Ljbffr
Overview of our lab. The
Tsai
lab is a highly collaborative, creative, and fun group of scientists at St. Jude Children’s Research Hospital. Our research program centers on: development of state-of-the-art genomic methods for understanding the global activities of genome editors, protein engineering to improve their capabilities for precise editing, and translation to autologous genome edited hematopoietic stem cell therapies.
About the job opportunity.
We are seeking an outstanding and highly motivated Scientist or Lead Researcher to help lead efforts to develop personalized genome editing treatments for bone marrow failure disorders. We care deeply about the success of our scientists and this job is a unique opportunity to learn about genomics, genome editing, and protein engineering while contributing to the development of future individualized genomic medicines at St. Jude, with room for career growth and advancement.
Dr. Tsai
is co-leading a new Blue Sky Project called PARADIGM (Partnership to Advance Development of Individualized Genomic Medicines) with goal of developing personalized genome editing therapies for St. Jude patients.
You would have opportunities to lead exciting projects that include:
Protein engineering of improved novel CRISPR base and prime genome editors with human cell-based directed evolution.
Understanding the structure-function relationship of mutations identified from high-throughput screens on the activity of genome editors.
Perform deep mutational scanning of CRISPR-Cas orthologues and effector domains important for precise genome editing such as deaminases and reverse transcriptases.
Define the outcome of engineered variants on genome editing repair outcomes using high-throughput genomic methods.
Help develop laboratory automation workflows to perform scalable protein engineering.
You would learn valuable laboratory skills that include:
Genome engineering, high-throughput genomics, next-generation sequencing, protein engineering, structural biology, liquid handling automation, hematopoietic stem cell cell culture and transfection, and data science.
Project-dependent responsibilities could include:
Engineer CRISPR base and prime editors with improved activity and specificities.
Test new strategies to edit human hematopoietic stem cells for treatment of bone marrow failure disorders, focused on rapid development of editing strategies for rare patient-specific mutations.
Optimize lead protein candidates by structure-guided design and high-throughput screening.
Apply new machine learning techniques to guide protein engineering design.
Analyze experimental outcomes and develop high-quality summaries towards manuscripts and grant applications.
Draft manuscripts and figures for publication in high-impact journals.
Minimum Education and/or Training for the position include:
A B.S. in a relevant field, such as genomics, molecular and cell biology.
1 year or more of hands-on, research laboratory experience.
Excellent communication, organizational, and presentation skills.
Scientist Minimum Experience:
Seven (7) years of relevant post-degree work experience is required.
Five (5) years of relevant post-degree work experience is required with a Master's degree.
Three (3) years of relevant post-degree work experience is required with a PhD.
Lead Researcher Minimum Experience:
Five (5) years of relevant, post-degree work experience is required.
Two (2) years of relevant post-degree work experience is required with a Master's degree.
No experience is required with a PhD.
Application process
Apply now
to join our talented team!
Please include your resume and a cover letter addressed to Dr. Tsai who will read and review all qualified applications. If you have questions about the position, please don’t hesitate to e-mail Dr. Tsai directly ( shengdar.tsai@stjude.org ).
#J-18808-Ljbffr