GlaxoSmithKline
Senior Scientist, Medicinal Chemistry
GlaxoSmithKline, Collegeville, Pennsylvania, United States, 19426
Site Name:
USA - Pennsylvania - Upper ProvidencePosted Date:
Sep 25 2024We are currently looking for highly motivated organic chemists to join our Medicinal Chemistry team in suburban Philadelphia.
Our department partners with program teams across GSK’s research units to deliver high quality small molecules, from hit generation through late-stage lead optimization to address increasingly complex disease areas. The purpose of the role is to provide a high level of scientific and technical contributions to projects within the Medicinal Chemistry portfolio (including but not limited to: small molecules, PROTACs, degraders, oligonucleotides, covalents, and antibody-drug conjugates) with a primary responsibility of driving efficiencies applying novel synthetic methods and techniques to design, synthesize, and purify candidate molecules. The successful applicant will become fluent in all areas of medicinal chemistry while working as part of a highly productive team to design and synthesize developable drug molecules. The role involves, to differing degrees, medicinal chemistry, data analytics, designing compounds to test medicinal chemistry hypotheses, synthetic organic chemistry to support both medicinal chemistry and/or candidate selection and championing technological advances.The successful candidate will work collaboratively across teams of synthetic chemists, analytical chemists, and data analytics experts to help invent these new processes and chemistries to solve impactful problems that will accelerate delivery of important medicinal advancements to patients. Successful candidates must be able to think creatively, champion the needs of the organization and work
collaboratively within a team environment.
This is an
on-site,
lab-based role. Hybrid work is not an option.This role will provide you the opportunity to lead key activities to progress your career. These responsibilities include some of the following:Apply modern synthetic technologies to the preparation of structurally complex organic molecules by performing multi-step organic synthesis to prepare intermediates and final products, from milligram to multigram reaction scalePropose synthetic routes to targeted molecules including the ability to optimize and troubleshoot chemical reactionsUse and operate analytical instrumentation for the analysis and characterization of organic compounds (NMR/LCMS/HPLC)Maintain accurate and detailed laboratory records using Electronic NotebookAssess and interpret data from biological assays to inform future compound designWork effectively in both independent and highly collaborative, multi-functional teams to drive projects forwardPrepare summaries of research results and communicate findings to team members through written reports and oral presentationsStay current with developments in the field of synthetic organic chemistry, medicinal chemistry, and drug discovery through literature reviewWrite-up experimental procedures for journal and patent applications to secure GSK’s intellectual propertyAct in accordance with all GSK policies on personnel, safety/health/environment regulations, best laboratory practice, and Code of ConductWhen submitting your CV/Resume please also include a Research StatementQualifications:Master’s degree in Chemistry, Chemical Biology, or Biochemistry orBachelor’s degree in Chemistry, Chemical Biology, or Biochemistry degree in these areas with 2+ years relevant industry experiencePreferred Qualifications:Master’s degree in Chemistry, Chemical Biology, or Biochemistry with 2+ years industry experienceExperience in synthetic chemistry; the application of new synthetic methodology and execution of multi-step syntheses.Peer-reviewed publications, patents, or presentationsProven track record of lab-based synthetic organic chemistry experienceTechnically sound in organic chemistry fundamentals: strong understanding of reactions, mechanisms, and reactivityProficient in searching the chemical literature to evaluate potential solutions to synthetic challengesStrong problem solving abilities, including critical thinking skills and attention to detailExcellent interpersonal and communication skills#LI-GSKPlease visit
GSK US Benefits Summary
t o learn more about the comprehensive benefits program GSK offers US employees.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting
For the Record
site.
#J-18808-Ljbffr
USA - Pennsylvania - Upper ProvidencePosted Date:
Sep 25 2024We are currently looking for highly motivated organic chemists to join our Medicinal Chemistry team in suburban Philadelphia.
Our department partners with program teams across GSK’s research units to deliver high quality small molecules, from hit generation through late-stage lead optimization to address increasingly complex disease areas. The purpose of the role is to provide a high level of scientific and technical contributions to projects within the Medicinal Chemistry portfolio (including but not limited to: small molecules, PROTACs, degraders, oligonucleotides, covalents, and antibody-drug conjugates) with a primary responsibility of driving efficiencies applying novel synthetic methods and techniques to design, synthesize, and purify candidate molecules. The successful applicant will become fluent in all areas of medicinal chemistry while working as part of a highly productive team to design and synthesize developable drug molecules. The role involves, to differing degrees, medicinal chemistry, data analytics, designing compounds to test medicinal chemistry hypotheses, synthetic organic chemistry to support both medicinal chemistry and/or candidate selection and championing technological advances.The successful candidate will work collaboratively across teams of synthetic chemists, analytical chemists, and data analytics experts to help invent these new processes and chemistries to solve impactful problems that will accelerate delivery of important medicinal advancements to patients. Successful candidates must be able to think creatively, champion the needs of the organization and work
collaboratively within a team environment.
This is an
on-site,
lab-based role. Hybrid work is not an option.This role will provide you the opportunity to lead key activities to progress your career. These responsibilities include some of the following:Apply modern synthetic technologies to the preparation of structurally complex organic molecules by performing multi-step organic synthesis to prepare intermediates and final products, from milligram to multigram reaction scalePropose synthetic routes to targeted molecules including the ability to optimize and troubleshoot chemical reactionsUse and operate analytical instrumentation for the analysis and characterization of organic compounds (NMR/LCMS/HPLC)Maintain accurate and detailed laboratory records using Electronic NotebookAssess and interpret data from biological assays to inform future compound designWork effectively in both independent and highly collaborative, multi-functional teams to drive projects forwardPrepare summaries of research results and communicate findings to team members through written reports and oral presentationsStay current with developments in the field of synthetic organic chemistry, medicinal chemistry, and drug discovery through literature reviewWrite-up experimental procedures for journal and patent applications to secure GSK’s intellectual propertyAct in accordance with all GSK policies on personnel, safety/health/environment regulations, best laboratory practice, and Code of ConductWhen submitting your CV/Resume please also include a Research StatementQualifications:Master’s degree in Chemistry, Chemical Biology, or Biochemistry orBachelor’s degree in Chemistry, Chemical Biology, or Biochemistry degree in these areas with 2+ years relevant industry experiencePreferred Qualifications:Master’s degree in Chemistry, Chemical Biology, or Biochemistry with 2+ years industry experienceExperience in synthetic chemistry; the application of new synthetic methodology and execution of multi-step syntheses.Peer-reviewed publications, patents, or presentationsProven track record of lab-based synthetic organic chemistry experienceTechnically sound in organic chemistry fundamentals: strong understanding of reactions, mechanisms, and reactivityProficient in searching the chemical literature to evaluate potential solutions to synthetic challengesStrong problem solving abilities, including critical thinking skills and attention to detailExcellent interpersonal and communication skills#LI-GSKPlease visit
GSK US Benefits Summary
t o learn more about the comprehensive benefits program GSK offers US employees.Why GSK?Uniting science, technology and talent to get ahead of disease together.GSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people and deliver stronger, more sustainable shareholder returns – as an organisation where people can thrive. We prevent and treat disease with vaccines, specialty and general medicines. We focus on the science of the immune system and the use of new platform and data technologies, investing in four core therapeutic areas (infectious diseases, HIV, respiratory/ immunology and oncology).Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive. We want GSK to be a place where people feel inspired, encouraged and challenged to be the best they can be. A place where they can be themselves – feeling welcome, valued, and included. Where they can keep growing and look after their wellbeing. So, if you share our ambition, join us at this exciting moment in our journey to get Ahead Together.If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US).GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class.Important notice to Employment businesses/ AgenciesGSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site.Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK’s compliance to all federal and state US Transparency requirements. For more information, please visit GSK’s Transparency Reporting
For the Record
site.
#J-18808-Ljbffr