AbbVie
Scientist I Discovery Biotherapeutics Multispecifics Engineering
AbbVie, Worcester, Massachusetts, us, 01609
Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at
www.abbvie.com . Follow @abbvie on
Twitter ,
Facebook ,
Instagram ,
YouTube
and
LinkedIn .
Job Description
Biologics Discovery Sciences at AbbVie is seeking a highly motivated research scientist to join a dynamic team supporting biologics drug discovery and multispecifics engineering. This position will impact projects through the discovery and engineering of biopharmaceutical products. The ideal candidate should have strong experience with a variety of molecular cloning techniques as they relate to multispecifics biologics assembly and knowledge of antibody fragments and mimetics. Other desirable skills include experience with antibody engineering, protein purification expertise, and familiarity with sequence analysis tools and molecular modeling software. The applicant should be able to analyze, document, and report data. She/he should possess excellent communication skills and be comfortable presenting in group settings.
Qualifications:
BS or MS in biology or related field with 5+ years (BS), or 2+ years (MS) of pharmaceutical and/or relevant experience
Strong molecular biology skills (e.g., molecular cloning)
Familiarity with sequence analysis tools (Vector NTI, Geneious, Genedata)
Experience with bacterial and mammalian cell culture
Experience with protein, biologics, fragments, and multi-specifics purification
Experience with
in vitro
analytical techniques for protein characterization (e.g. SEC, MS, DSF)
Understanding of protein structure and function
Excellent oral and written communication skills
Excellent organization skills and the ability to manage multiple projects simultaneously
Team player with the ability to operate in a fast-paced multi-disciplinary environment
Adapt to rapid changes in project priorities and timelines
Competency with software programs, including MS Excel, Powerpoint, Word
Preferred:
Experience with antibody engineering, design, and optimization (e.g., humanization, Fc optimization, building multi-specifics)
Hands-on experience with SEC, HIC, IEX purification of complex biologics
Proficiency with mass spectrometry deconvolution and interpretation for complex biologics
Hands-on experience with binding assays (e.g., ELISA, flow cytometry)
Flow cytometry and cell sorting experience for antibody discovery
Utilization of automation (e.g. Hamilton, Tecan) equipment in Biologics discovery processes
Proficiency with the software programs Prism, Geneious, Sequencher, Genedata, PMI, Bioconfirm, Unicorn
Experience training junior scientists
Experience with CRO coordination
Significant Work Activities and Conditions
Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance.
Learns fast, grasps the “essence” and can change the course quickly where indicated.
Raises the bar and is never satisfied with the status quo.
Creates a learning environment, open to suggestions and experimentation for improvement.
Embraces the ideas of others, nurtures innovation and manages innovation to reality.
Salary:
$71,000 - $134,500
#J-18808-Ljbffr
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at
www.abbvie.com . Follow @abbvie on
Twitter ,
Facebook ,
Instagram ,
YouTube
and
LinkedIn .
Job Description
Biologics Discovery Sciences at AbbVie is seeking a highly motivated research scientist to join a dynamic team supporting biologics drug discovery and multispecifics engineering. This position will impact projects through the discovery and engineering of biopharmaceutical products. The ideal candidate should have strong experience with a variety of molecular cloning techniques as they relate to multispecifics biologics assembly and knowledge of antibody fragments and mimetics. Other desirable skills include experience with antibody engineering, protein purification expertise, and familiarity with sequence analysis tools and molecular modeling software. The applicant should be able to analyze, document, and report data. She/he should possess excellent communication skills and be comfortable presenting in group settings.
Qualifications:
BS or MS in biology or related field with 5+ years (BS), or 2+ years (MS) of pharmaceutical and/or relevant experience
Strong molecular biology skills (e.g., molecular cloning)
Familiarity with sequence analysis tools (Vector NTI, Geneious, Genedata)
Experience with bacterial and mammalian cell culture
Experience with protein, biologics, fragments, and multi-specifics purification
Experience with
in vitro
analytical techniques for protein characterization (e.g. SEC, MS, DSF)
Understanding of protein structure and function
Excellent oral and written communication skills
Excellent organization skills and the ability to manage multiple projects simultaneously
Team player with the ability to operate in a fast-paced multi-disciplinary environment
Adapt to rapid changes in project priorities and timelines
Competency with software programs, including MS Excel, Powerpoint, Word
Preferred:
Experience with antibody engineering, design, and optimization (e.g., humanization, Fc optimization, building multi-specifics)
Hands-on experience with SEC, HIC, IEX purification of complex biologics
Proficiency with mass spectrometry deconvolution and interpretation for complex biologics
Hands-on experience with binding assays (e.g., ELISA, flow cytometry)
Flow cytometry and cell sorting experience for antibody discovery
Utilization of automation (e.g. Hamilton, Tecan) equipment in Biologics discovery processes
Proficiency with the software programs Prism, Geneious, Sequencher, Genedata, PMI, Bioconfirm, Unicorn
Experience training junior scientists
Experience with CRO coordination
Significant Work Activities and Conditions
Builds strong relationships with peers and cross functionally with partners outside of the team to enable higher performance.
Learns fast, grasps the “essence” and can change the course quickly where indicated.
Raises the bar and is never satisfied with the status quo.
Creates a learning environment, open to suggestions and experimentation for improvement.
Embraces the ideas of others, nurtures innovation and manages innovation to reality.
Salary:
$71,000 - $134,500
#J-18808-Ljbffr