Associate Scientist, Biologics Engineering

About Us:Fable Therapeutics (Fable) is a discovery-stage biotechnology company which develops purpose-built biologics designed to overcome therapeutic index limitations and channel therapeutic response where and when it matters.Fable is powered by state-of-the-art structure and sequence-based protein language models. Founded by leading ML scientists and veteran biotech entrepreneurs together with top-tier venture capital firms, Fable has recently initiated its internal therapeutic pipeline and has enacted a growing list of pharma research collaborations.Backed by a 2024 $40M Series A investment co-led by Versant Ventures and DCVC, Fable is positioned to lead in the purposeful integration of biology and computation to solve complex medical challenges. Fable’s aspiration is to write the next chapter of what protein-based therapeutics can do.Description:We are seeking a highly talented and motivated scientist to join our growing team and establish our in-house Biologics engineering capabilities. With experience in biologics drug discovery, you will be primarily responsible for enabling antibody-based constructs and production from our bespoke AI designed antibody libraries using eukaryotic systems. You will have the opportunity to contribute to designing the ideal lab environment to support your library and molecule building workflows, including molecular biology and robotics/automation. The data you generate will be used to train our state-of-the-art ML platform to design potent and drug-like antibodies.In order to execute on accountabilities, an on-premise working model is expected. Flexible working hours to promote a balance between productivity and wellness can be accommodated with manager approval.Responsibilities:Generation of antibody-based constructs and libraries from AI designed sequencesMolecular Biology, DNA vector designs and DNA cloning capabilitiesDNA sequence analysisSubcloning of hits into mammalian expression vectorsSite-directed mutagenesisExpression and purification of antibody constructs in mammalian cell culture at micro, medium and large scale as appropriateBinding assays based on FACS, flow cytometry and ELISACareful documentation and record-keeping of scientific resultsMolecule registration and inventory, and data upload to databases and LIMS systemsCuration of data for ingestion and utilization by ML scientistsAbout You:BA in Molecular Biology or Protein Engineering and 4+ years industry experience in biologics discovery and protein science OR MSc and 2+ years experienceExcellent molecular biology, DNA cloning and protein engineering skillsFamiliarity with liquid handling systems and high-throughput screening systemsCommitted to digital workflows and the lab of the futureAbility to work efficiently in a close-knit team and deliver high quality, reproducible data in a fast-paced environmentAttentive to detail and careful experimentationAbility to take initiative and improve processesAn excellent communicator and presenter of scientific dataPassionate about the power of AI to transform biotherapeuticsFocused on quantifiable results and data driven decisionsCollaborative and inclusive mindsetAt Fable Therapeutics, we know that our people drive our success. We are an equal opportunity employer and we value diversity and inclusion. Fable Therapeutics provides an open, collegial, and friendly work environment where we empower people and provide them with opportunities to develop their long-term careers. Fable Therapeutics does not discriminate on the basis of race, color, religion, sexual orientation, gender, age, physical or mental disability, or any other status protected under federal, state, or local law.

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