Deciphera Pharmaceuticals, Inc
Senior Scientist I, Biological Sciences
Deciphera Pharmaceuticals, Inc, Lawrence, Kansas, us, 66045
Deciphera is a biopharmaceutical company focused on discovering, developing and commercializing important new medicines to improve the lives of people with cancer. We are leveraging our proprietary switch-control kinase inhibitor platform and deep expertise in kinase biology to develop a broad portfolio of innovative medicines.Enabled by our proprietary drug discovery platform, Deciphera has developed a diverse pipeline of wholly-owned drug candidates. QINLOCK (ripretinib) is Deciphera’s switch control inhibitor developed for the treatment of fourth-line GIST. QINLOCK is approved in multiple countries including Australia, Canada, China, the European Union, Hong Kong, Switzerland, Taiwan, the United States, and the United Kingdom. We wholly own QINLOCK and all of our drug candidates with the exception of a development and commercialization out-license agreement for QINLOCK in Greater China. In addition to QINLOCK, we have identified and advanced multiple product candidates from our platform into clinical studies, including vimseltinib and DCC-3116.Job Description
We are seeking a highly motivated, creative, and collaborative Senior Scientist to join our Biological Sciences drug discovery group. This position will be responsible for designing, performing, coordinating, and interpreting structural biology, biochemical, biophysical, and cellular experiments for our drug discovery programs. This includes the development of relevant model systems for the identification, validation, and screening of compounds against novel therapeutic targets. The successful candidate will work independently, but also as an integral part of a larger team to achieve collective goals. The ideal candidate will have a deep understanding of biochemistry and structural biology and will apply this knowledge to challenging ongoing and new drug discovery programs.This position will report to a Senior Director, Biological Sciences, and work onsite at our research facility in Lawrence, Kansas.What You’ll Do:Conceive, develop, and optimize biochemical and cellular assays to determine the therapeutic potential of rationally designed targeted small moleculesDesign and conduct rigorous experiments to identify and validate potential novel drug targetsWork collaboratively with biologists, medicinal chemists, and external partners to deliver high quality structures of macromolecular complexes, custom proteins, and reagentsDocument experimental design, analysis, and interpretation of data in an ELN and LIMS systemStay abreast of the latest scientific and technological advancements in the fieldAuthor technical reports and presentations to communicate data and analyses effectivelyAdd to Deciphera culture of collaboration and shared mission to solve complex biological problemsAdhere to corporate policies including safety and complianceQualifications
A PhD in Biochemistry or related field with 4+ years of biotech or pharma industry experienceAn ability to think independently to design high-throughput experiments and generate robust, reproducible resultsExperience working with automated laboratory instruments including ECHO, Bravo, and multi-mode plate readersExpertise in biochemistry, HTS assay development, molecular biology, protein purification, X-ray crystallography or Cryo EM. Familiarity with biophysical techniques such as protein MS, SPR, ITC, MST, DSF is preferredAdaptability to work in a dynamic, fast-paced environmentExcellent communication and presentation skillsAdditional Information
We are proud to be Great Place to Work Certified 2023 and rank #25 on Fortune’s Best Places to Work Small and Midsized Biotech Companies in 2023. We offer an outstanding culture and opportunity for personal and professional growth based on our “PATHS” Core Values:Patients –We are committed to improving the lives of patients living with cancer. They are the driving force behind everything we do.Accountability –We demand accountability for our actions, behaviors, and performance. We recognize our duty to maintain a culture that embraces the uniqueness of our people and finds strength in our differences.Transparency –We strive to provide full visibility to internal and external stakeholders for a complete picture of what we are doing and why.Honesty and Integrity –Trust and mutual respect are essential aspects of our culture. We act with honesty and integrity in all facets of our business, and this serves as the foundation of our work and interactions with others.Stewardship –We are respectful of the resources entrusted to us by the investment community. We act thoughtfully and allocate resources responsibly in seeking to create value for our shareholders.EQUAL EMPLOYMENT OPPORTUNITY INFORMATIONDeciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements and to learn more about how we can increase diversity in our candidate pool, we invite you to voluntarily provide demographic information in a confidential survey at the end of this application. Providing this information is optional. It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially.
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We are seeking a highly motivated, creative, and collaborative Senior Scientist to join our Biological Sciences drug discovery group. This position will be responsible for designing, performing, coordinating, and interpreting structural biology, biochemical, biophysical, and cellular experiments for our drug discovery programs. This includes the development of relevant model systems for the identification, validation, and screening of compounds against novel therapeutic targets. The successful candidate will work independently, but also as an integral part of a larger team to achieve collective goals. The ideal candidate will have a deep understanding of biochemistry and structural biology and will apply this knowledge to challenging ongoing and new drug discovery programs.This position will report to a Senior Director, Biological Sciences, and work onsite at our research facility in Lawrence, Kansas.What You’ll Do:Conceive, develop, and optimize biochemical and cellular assays to determine the therapeutic potential of rationally designed targeted small moleculesDesign and conduct rigorous experiments to identify and validate potential novel drug targetsWork collaboratively with biologists, medicinal chemists, and external partners to deliver high quality structures of macromolecular complexes, custom proteins, and reagentsDocument experimental design, analysis, and interpretation of data in an ELN and LIMS systemStay abreast of the latest scientific and technological advancements in the fieldAuthor technical reports and presentations to communicate data and analyses effectivelyAdd to Deciphera culture of collaboration and shared mission to solve complex biological problemsAdhere to corporate policies including safety and complianceQualifications
A PhD in Biochemistry or related field with 4+ years of biotech or pharma industry experienceAn ability to think independently to design high-throughput experiments and generate robust, reproducible resultsExperience working with automated laboratory instruments including ECHO, Bravo, and multi-mode plate readersExpertise in biochemistry, HTS assay development, molecular biology, protein purification, X-ray crystallography or Cryo EM. Familiarity with biophysical techniques such as protein MS, SPR, ITC, MST, DSF is preferredAdaptability to work in a dynamic, fast-paced environmentExcellent communication and presentation skillsAdditional Information
We are proud to be Great Place to Work Certified 2023 and rank #25 on Fortune’s Best Places to Work Small and Midsized Biotech Companies in 2023. We offer an outstanding culture and opportunity for personal and professional growth based on our “PATHS” Core Values:Patients –We are committed to improving the lives of patients living with cancer. They are the driving force behind everything we do.Accountability –We demand accountability for our actions, behaviors, and performance. We recognize our duty to maintain a culture that embraces the uniqueness of our people and finds strength in our differences.Transparency –We strive to provide full visibility to internal and external stakeholders for a complete picture of what we are doing and why.Honesty and Integrity –Trust and mutual respect are essential aspects of our culture. We act with honesty and integrity in all facets of our business, and this serves as the foundation of our work and interactions with others.Stewardship –We are respectful of the resources entrusted to us by the investment community. We act thoughtfully and allocate resources responsibly in seeking to create value for our shareholders.EQUAL EMPLOYMENT OPPORTUNITY INFORMATIONDeciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements and to learn more about how we can increase diversity in our candidate pool, we invite you to voluntarily provide demographic information in a confidential survey at the end of this application. Providing this information is optional. It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially.
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