Sparxbio
Senior Scientist of Bioanalysis
Sparxbio, Oregon, Illinois, United States, 61061
We are seeking a highly motivated and enthusiastic Senior Scientist for analytical solutions of difficult scope and complexity from early discovery, scale-up, and process development to GMP quality control for a wide range of biologic R&D products. You will be responsible for the development of state-of-the-art analytical techniques for the characterization of monoclonal and multi-specific antibody drug candidates. You will be also supporting other groups particularly in Downstream Process Development. The ideal candidate will have 2 years of industry experience with a Ph.D. degree, or 5 years of industry experience with an MS degree in Chemistry, Biochemistry, Chemical/Biochemical Engineering, Biotechnology, Cell Biology, or related disciplines.Principal Duties and Responsibilities:
Develop, evaluate and qualify analytical methods supporting early discovery, scale-up, and process development for monoclonal and multi-specific antibody drug candidates.Deliver timely and comprehensive written (laboratory notebooks, SOPs, and development and qualification protocols/reports) and oral communications to both internal and external stakeholders.Required Qualifications:
Ph.D. in Analytical or Bio-Analytical Chemistry with 2+ years of industrial experience – OR – Master’s Degree in Analytical or Bio-Analytical Chemistry with 5+ years of industrial experience – OR – Bachelor’s degree with 8+ years of industrial experience.A strong background and hands-on experience in developing, validating, and implementing various chromatography assays to support the development of antibody drugs across all therapeutic areas.Preferred Qualifications:
Extensive hands-on experience and in-depth knowledge of 5 or more of the following bio/analytical technologies including: chromatography (HPLC/IC/UPLC/LC-MS/ SEC/HILIC/), electrophoresis (capillary CGE or iCE and traditional gel techniques), SDS-PAGE, immunochemical assays (ELISA, western blot, and dot blot), enzyme kinetics, and plate-based biochemical assays, absorption spectroscopy, slope spectroscopy, protein characterization, protein functional assays, FTIR, NMR, and/or USP methodologies.Experience in characterizing the biophysical properties/stability of complex antibody molecules (ie. CD, intrinsic fluorescence, ANS fluorescence, differential scanning calorimetry, dynamic scanning fluorimetry).Demonstrated experience in the application of techniques used to characterize post-translational modifications and sources of heterogeneity (HPLC/UPLC, LC-MS, Capillary Electrophoresis (CGE, cIEF), SDS-PAGE, charge variants (AEX/CEX/CIEF/iCIEF), N-glycans, peptide mapping and aggregation/HMW analysis (Size Exclusion Chromatography).Current knowledge and hands-on experience on bioanalytical development process, particularly on monoclonal and multi-specific antibody drug candidates.Well-versed in regulatory requirements to assure appropriate design and execution of drug development and manufacturing.About SparX Group
SparX Biopharmaceutical Corp. is a research-based development-stage biopharmaceutical company, dedicated to the mission of “strengthening human immunity using robust antibody therapies” through the discovery and development of innovative immuno-oncology agents.EEOC Statement:
Sparx is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates. Sparx is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, marital status, sexual orientation, genetic information, uniform service member or veteran status, or any other characteristic protected by federal, state or local law.
#J-18808-Ljbffr
Develop, evaluate and qualify analytical methods supporting early discovery, scale-up, and process development for monoclonal and multi-specific antibody drug candidates.Deliver timely and comprehensive written (laboratory notebooks, SOPs, and development and qualification protocols/reports) and oral communications to both internal and external stakeholders.Required Qualifications:
Ph.D. in Analytical or Bio-Analytical Chemistry with 2+ years of industrial experience – OR – Master’s Degree in Analytical or Bio-Analytical Chemistry with 5+ years of industrial experience – OR – Bachelor’s degree with 8+ years of industrial experience.A strong background and hands-on experience in developing, validating, and implementing various chromatography assays to support the development of antibody drugs across all therapeutic areas.Preferred Qualifications:
Extensive hands-on experience and in-depth knowledge of 5 or more of the following bio/analytical technologies including: chromatography (HPLC/IC/UPLC/LC-MS/ SEC/HILIC/), electrophoresis (capillary CGE or iCE and traditional gel techniques), SDS-PAGE, immunochemical assays (ELISA, western blot, and dot blot), enzyme kinetics, and plate-based biochemical assays, absorption spectroscopy, slope spectroscopy, protein characterization, protein functional assays, FTIR, NMR, and/or USP methodologies.Experience in characterizing the biophysical properties/stability of complex antibody molecules (ie. CD, intrinsic fluorescence, ANS fluorescence, differential scanning calorimetry, dynamic scanning fluorimetry).Demonstrated experience in the application of techniques used to characterize post-translational modifications and sources of heterogeneity (HPLC/UPLC, LC-MS, Capillary Electrophoresis (CGE, cIEF), SDS-PAGE, charge variants (AEX/CEX/CIEF/iCIEF), N-glycans, peptide mapping and aggregation/HMW analysis (Size Exclusion Chromatography).Current knowledge and hands-on experience on bioanalytical development process, particularly on monoclonal and multi-specific antibody drug candidates.Well-versed in regulatory requirements to assure appropriate design and execution of drug development and manufacturing.About SparX Group
SparX Biopharmaceutical Corp. is a research-based development-stage biopharmaceutical company, dedicated to the mission of “strengthening human immunity using robust antibody therapies” through the discovery and development of innovative immuno-oncology agents.EEOC Statement:
Sparx is an equal opportunity employer and complies with all applicable equal employment opportunity legislation in each jurisdiction in which it operates. Sparx is committed to providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability, marital status, sexual orientation, genetic information, uniform service member or veteran status, or any other characteristic protected by federal, state or local law.
#J-18808-Ljbffr