Sarepta Therapeutics
Research Associate II, Gene Therapy Analytical Development
Sarepta Therapeutics, Andover, Massachusetts, us, 05544
Why Sarepta? Why Now?The promise of genetic medicine has arrived, and Sarepta is at the forefront. We hold leadership positions in Duchenne muscular dystrophy (DMD) and limb-girdle muscular dystrophies (LGMDs), and we currently have more than 40 programs in various stages of development in gene therapy, RNA and gene editing. In 2023, we launched our fourth therapy and the first ever gene therapy to treat Duchenne.We're looking for people who see unlimited potential in themselves and who are motivated by an unwavering commitment to patients.What Sarepta OffersAt Sarepta, we care deeply about all the people in our community and believe in the importance of supporting them in all aspects of their lives. We aspire to maintain a culture that acknowledges people bring their whole selves to work, and we will strive to help everyone in our community integrate their work and personal lives while maintaining productivity. We are committed to offering a range of benefits and work-life resources designed to support people in the following areas:Physical and Emotional WellnessFinancial WellnessSupport for CaregiversFor a full list of our comprehensive benefits, see our website:
https://www.sarepta.com/join-usThe Importance of the RoleThis individual will support analytical development activities conducted at Sarepta Andover facility in the field of in vitro potency of AAV based Drug products. The individual will help in the development and validation of cell-based in vitro potency assays. The position requires a strong background in cell culture, sample preparation and protein analysis. The work involves performing assays in a BSL-2 environment. The individual will be responsible for conducting experiments, reviewing in vitro potency data, writing technical reports, supporting analytical method validation and qualification activities. The individual will also assist in managing the instrument validation and qualification. All aspects of this position would involve working in a GMP compliant manner.The Opportunity to Make a DifferenceConduct laboratory experiments involving in vitro potency methods in support of release and stability testing of AAV based gene therapy products.Prepare, qualify, and release standards for the in vitro potency methods.Test new cell lines for use in new potency assays.Maintain cell banks in cryogenic storage.Create and maintain clear and concise lab records and documentation.Author test methods, development reports, study protocols, and validation reports.Independently define and execute experiments as well as suggest improvements and solutions to address new problems as they arise.Support the method development, transfer and qualification/validation activities associated with the release of viral vector products.Assist in writing and reviewing quality documents such as SOPs and technical reports.Perform other related duties incidental to the work described.More about YouB.S. or M.S. degree in molecular biology, cell biology or virology with at least 2-5 years relevant experience.Working experience in a cGMP environment is preferred.A strong understanding of cell culture methods, capillary based immune-assays, and cell banking is necessary.Experience in general laboratory experimentation, documentation with adherence to cGMP is necessary.Experience in developing, validating, and deploying molecular biology test methods is useful.Experience with reading and synthesizing primary literature is useful.Must have effective written and verbal communication skills, including presentation skills.Operate as part of a team, assisting fellow lab associates in providing a functional, safe working environment while maximizing laboratory efficiency.What Now?We're always looking for solution-oriented, critical thinkers. So, if you're comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.This position requires work on site at one of Sarepta's facilities in the United States. The targeted salary range for this position is $68,000 - $85,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta's compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
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https://www.sarepta.com/join-usThe Importance of the RoleThis individual will support analytical development activities conducted at Sarepta Andover facility in the field of in vitro potency of AAV based Drug products. The individual will help in the development and validation of cell-based in vitro potency assays. The position requires a strong background in cell culture, sample preparation and protein analysis. The work involves performing assays in a BSL-2 environment. The individual will be responsible for conducting experiments, reviewing in vitro potency data, writing technical reports, supporting analytical method validation and qualification activities. The individual will also assist in managing the instrument validation and qualification. All aspects of this position would involve working in a GMP compliant manner.The Opportunity to Make a DifferenceConduct laboratory experiments involving in vitro potency methods in support of release and stability testing of AAV based gene therapy products.Prepare, qualify, and release standards for the in vitro potency methods.Test new cell lines for use in new potency assays.Maintain cell banks in cryogenic storage.Create and maintain clear and concise lab records and documentation.Author test methods, development reports, study protocols, and validation reports.Independently define and execute experiments as well as suggest improvements and solutions to address new problems as they arise.Support the method development, transfer and qualification/validation activities associated with the release of viral vector products.Assist in writing and reviewing quality documents such as SOPs and technical reports.Perform other related duties incidental to the work described.More about YouB.S. or M.S. degree in molecular biology, cell biology or virology with at least 2-5 years relevant experience.Working experience in a cGMP environment is preferred.A strong understanding of cell culture methods, capillary based immune-assays, and cell banking is necessary.Experience in general laboratory experimentation, documentation with adherence to cGMP is necessary.Experience in developing, validating, and deploying molecular biology test methods is useful.Experience with reading and synthesizing primary literature is useful.Must have effective written and verbal communication skills, including presentation skills.Operate as part of a team, assisting fellow lab associates in providing a functional, safe working environment while maximizing laboratory efficiency.What Now?We're always looking for solution-oriented, critical thinkers. So, if you're comfortable with ambiguity and candor, relish challenging yourself, and place kindness and integrity at the forefront of how you approach your peers and work, then we encourage you to apply.This position requires work on site at one of Sarepta's facilities in the United States. The targeted salary range for this position is $68,000 - $85,000 per year. Sarepta is making a good faith effort to be transparent and accurate around our hiring ranges. The salary offer is commensurate with Sarepta's compensation philosophy and considers factors including, but not limited to, education, training, experience, external market conditions, criticality of role, and internal equity. Candidates must be authorized to work in the U.S. Sarepta Therapeutics offers a competitive compensation and benefit package. Sarepta Therapeutics is an Equal Opportunity/Affirmative Action employer and participates in e-Verify.
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