PetsApp
Scientist II to Associate Director, Gene Therapy Development
PetsApp, Cambridge, Massachusetts, us, 02140
Gene Therapy DevelopmentAt Source Bio, we are working on novel AAV gene therapy technologies – making AAV gene therapy safer, cheaper, and better for everyone. It is a big mission, and we are looking for talented, ambitious, optimistic people to join our team.We are a seed stage, venture backed biotech company and are currently in stealth mode (so don’t bother looking for a website).We are currently searching for a passionate and innovative Scientist I to Sr. Scientist who excels at in vivo and in vitro experimentation to drive therapeutic candidate development in gene therapy. The ideal candidate will also bring expertise in immunology and tolerance induction for protein and gene therapeutics. Working hand-in-hand with the CSO and head of Vectorology, this Scientist will be a critical member of the founding team here at Source Bio.ResponsibilitiesOrganize, execute and interpret in vivo experiments at local CROs to characterize and optimize Source’s therapeutic candidates.
Establish, execute, and interpret in vitro and cell-based workflows for testing and optimizing candidates.
Design strategy around assessment and mitigation of in vivo immunological response to each candidate.
Contribute to vector and protein design as necessary.
Opportunity to drive therapeutic candidates into IND-enabling studies.
QualificationsPh.D. in pharmacology, molecular biology, immunology, or a related field.
2+ years of industry experience preferred.
Direct experience in the design, testing, and development of gene therapies.
Deep experience managing CROs to enable timely and successful execution of in vivo experiments.
Skill with in vitro and cell-based assays, including transfection, ELISA and Western blotting, various microscopy techniques.
Skill with PCR-based assays, such as qPCR, RT-PCR and ddPCR.
Expertise in immunology and immunological assessment preferred.
Significant experience in project progression, experimental prioritization, project teams and line responsibilities.
Competence in plasmid construction for AAV, viral, or non-viral gene therapy preferred.
Source Bio is committed to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
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Establish, execute, and interpret in vitro and cell-based workflows for testing and optimizing candidates.
Design strategy around assessment and mitigation of in vivo immunological response to each candidate.
Contribute to vector and protein design as necessary.
Opportunity to drive therapeutic candidates into IND-enabling studies.
QualificationsPh.D. in pharmacology, molecular biology, immunology, or a related field.
2+ years of industry experience preferred.
Direct experience in the design, testing, and development of gene therapies.
Deep experience managing CROs to enable timely and successful execution of in vivo experiments.
Skill with in vitro and cell-based assays, including transfection, ELISA and Western blotting, various microscopy techniques.
Skill with PCR-based assays, such as qPCR, RT-PCR and ddPCR.
Expertise in immunology and immunological assessment preferred.
Significant experience in project progression, experimental prioritization, project teams and line responsibilities.
Competence in plasmid construction for AAV, viral, or non-viral gene therapy preferred.
Source Bio is committed to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
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