PetsApp
Scientist II to Associate Director, Protein Design
PetsApp, Cambridge, Massachusetts, us, 02140
Therapeutic Protein Design
At Source Bio, we are working on novel AAV gene therapy technologies – making AAV gene therapy safer, cheaper, and better for everyone. We are a seed stage, venture backed biotech company and are currently in stealth mode.
We are currently searching for a passionate and innovative Scientist I to Sr. Scientist who excels at engineering the in vivo properties of therapeutic proteins, including half-life extension, activity enhancement by rational design, and mitigation of immune response. Working hand-in-hand with the CSO and head of Vectorology, this Protein Engineer will be a critical member of the founding team here at Source Bio.
Responsibilities
Model, design, and test protein, antibody, and peptide payloads encoded in Source’s gene therapy vectors, focusing on enhancing secretion and plasma half-life, and reducing immunogenicity.
Establish and execute in vitro and cell-based assays for testing payload designs.
Provide expertise on antibody and antibody fragment engineering.
Help establish novel protein and vector design and testing technologies that advance the capabilities of the platform.
Implement cutting-edge techniques and tools (e.g. machine learning) for predicting optimal protein structures, immunogenicity, and post-translational modifications.
Qualifications
Ph.D. in protein biochemistry, molecular biology, or a related field.
2+ years of industry experience preferred.
Expertise in the design and testing of therapeutic proteins for drug and technology development.
Deep knowledge of interplay between amino acid modifications, post-translational modifications, PK/PD properties, and immunological responses in therapeutic protein design.
Expertise with therapeutic antibody design, including incorporation of Fc modifications.
Skill with in vitro and cell-based assays.
Competence in protein detection and characterization assays such as ELISA and western blotting. Exposure to mass spec/LC-MS.
Competence in plasmid construction for AAV, viral, or non-viral gene therapy preferred.
Skill with PCR-based assays, such as qPCR, RT-PCR and ddPCR preferred.
Source Bio is committed to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws.
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At Source Bio, we are working on novel AAV gene therapy technologies – making AAV gene therapy safer, cheaper, and better for everyone. We are a seed stage, venture backed biotech company and are currently in stealth mode.
We are currently searching for a passionate and innovative Scientist I to Sr. Scientist who excels at engineering the in vivo properties of therapeutic proteins, including half-life extension, activity enhancement by rational design, and mitigation of immune response. Working hand-in-hand with the CSO and head of Vectorology, this Protein Engineer will be a critical member of the founding team here at Source Bio.
Responsibilities
Model, design, and test protein, antibody, and peptide payloads encoded in Source’s gene therapy vectors, focusing on enhancing secretion and plasma half-life, and reducing immunogenicity.
Establish and execute in vitro and cell-based assays for testing payload designs.
Provide expertise on antibody and antibody fragment engineering.
Help establish novel protein and vector design and testing technologies that advance the capabilities of the platform.
Implement cutting-edge techniques and tools (e.g. machine learning) for predicting optimal protein structures, immunogenicity, and post-translational modifications.
Qualifications
Ph.D. in protein biochemistry, molecular biology, or a related field.
2+ years of industry experience preferred.
Expertise in the design and testing of therapeutic proteins for drug and technology development.
Deep knowledge of interplay between amino acid modifications, post-translational modifications, PK/PD properties, and immunological responses in therapeutic protein design.
Expertise with therapeutic antibody design, including incorporation of Fc modifications.
Skill with in vitro and cell-based assays.
Competence in protein detection and characterization assays such as ELISA and western blotting. Exposure to mass spec/LC-MS.
Competence in plasmid construction for AAV, viral, or non-viral gene therapy preferred.
Skill with PCR-based assays, such as qPCR, RT-PCR and ddPCR preferred.
Source Bio is committed to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws.
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