Marengo Therapeutics Inc
Senior Scientist, In-vivo Pharmacology
Marengo Therapeutics Inc, Cambridge, Massachusetts, us, 02140
Marengo Therapeutics is pioneering first-in-class therapeutics that activate the right immune response to promote lifelong protection against cancer. Marengo has uncovered a novel approach to T cell activation by targeting the Vß TCR chain to unleash rapid, potent, and long-lasting anti-tumor immune responses safely and effectively. We’re leveraging our versatile, proprietary bispecific fusion protein platform to selectively deliver the right activation to the right T cell subsets, customizable to patient needs with its tunable properties, with an initial focus on advanced solid tumors and broad applicability beyond.
Marengo is driven by core values that guide our company’s mission and approach from the inside out: we demonstrate an unparalleled commitment to patients and their loved ones, we are confident in our science and our team, we operate with courage, and we creatively apply deep expertise to new ways of thinking with curiosity and imagination. With an exciting journey ahead and a tremendous opportunity for growth, now is the time to join the Marengo team and impact cancer patient care – are you ready to join the new frontier?
Role: Senior Scientist, In-vivo Pharmacology
Marengo Therapeutics is seeking an experienced and highly motivated In vivo Pharmacologist to join our Immunology research team. As a member of Marengo’s Immunology research team, you will contribute to the characterization of novel T cell-engagers by driving in vivo pharmacological studies to identify clinical candidates.
Please: local candidates only. This is a full-time, lab-based role.
Who are we looking for?
You are an energetic and passionate In vivo Pharmacologist professional who likes to think outside of the box and challenge the norm, and you are passionate about the company’s mission of discovering and developing new medications.
You are an honest, respectful, highly flexible, and resourceful self-starter, results-oriented, and an excellent team player.
You consider yourself a guru in all the critical aspects of In vivo Pharmacology, with a solid understanding of biologics drug discovery, specifically related to the immuno-oncology field.
You can develop trusting relationships to gain support and achieve results at all levels of the organization and across departments (research, development, manufacturing, quality, clinical, and administrative).
You thrive in a dynamic small company environment.
What are we looking for?
Excellent verbal, interpersonal, and written communication skills.
Willingness to constantly expand your horizons with new knowledge, adapt to new ways, and go with the flow.
Ability to determine task priority and maintain established deadlines.
Ability to summarize complex scientific problems into clear strategies and tactics.
What are we offering?
Affiliation with a growing, CARING, and collegial organization.
Being part of a passionate, involved, and cutting-edge Immunology research team.
Exposure to pioneering science and the discovery of drugs to help treat patients in the oncology space.
Responsibilities:
Design, hands-on execution, and interpretation of a wide variety of in vivo pharmacological studies (PK, PD, efficacy, antigen-driven biodistribution, biomarker discovery) to assess drug exposure, target engagement, and anti-tumor activity, drug mechanism of action, and biomarker identification.
Record keeping of experimental data and results and maintain a current and accurate electronic notebook (ELN).
Contribute to in vivo pharmacological plan strategy, optimization and derive actionable biological conclusions and bring new experimental proposals.
Drive and work effectively within cross-functional teams in a matrix environment and implement critical studies to deliver lead/drug candidates to crucial inflection points.
Engage with broader project teams via teamwork to advance portfolio projects.
Provide ideas and perform research to identify and explore new opportunities for developing immune-mediated therapeutics, including continued evolution of the in vivo pharmacology platform at Marengo.
Develop a clear, fully resourced plan for project progression and deliver to agreed timelines.
Contribute to scientific literature through publication and presentation of research results.
Author documents relevant to regulatory submissions.
Manage relationships with off-site vivariums and maintain animal protocol up-to-date.
Education and Experience:
PhD with 6+ years or MS with 10+ years of directly relevant pharmaceutical/biotech industry experience in the field of cancer immunology, T cell biology and/or immuno-oncology, or related discipline with a focus on in vivo pharmacology.
Scientific expertise in in vivo models related to immuno-oncology/oncology, such as murine tumor xenograft, syngeneic, or patient-derived xenograft models.
Deep understanding of biologics drug discovery and early-stage drug development as relates to the critical requirement to build a pharmacology package for candidate drug nomination.
Competencies:
Adaptability : Responds resourcefully, flexibly, and positively when faced with new challenges, transitions, and demands. Willingly and effectively deals with the stress and complexities of various situations. Moves forward productively and optimistically under conditions of change and uncertainty.
Collaboration : Embodies and promotes collaboration and works effectively with others across the organization to achieve goals. Demonstrates proficient cross-company communication, cultural sensitivity, and partnership in interactions with others. Involves others in decisions and plans and credits them for their contributions and accomplishments.
Execution : Drives execution of strategic and operating plans while maintaining operational effectiveness. Conveys a strong sense of urgency around continuous improvement, achieving high-quality results, and accelerating business performance. Addresses problems directly and drives changes necessary to achieve business objectives.
Relationship Building : Establishes and maintains strong relationships internally and externally. Respects and relates well to management, colleagues, peers, and direct reports. Champions a culture of respect, diversity, and inclusion that values and respects individuals. Earns the respect of others through principled leadership, sound business ethics, and authenticity.
Location:
Cambridge, MA (We are located in Lower Cambridge, called Cambridgeport)
When You Join Marengo, You Will Have:
Free parking, Cambridge location reachable by public transportation (Red Line).
Customized and competitive health coverage, including medical offered through BCBS (HMO/PPO), dental, and vision.
Flexible Spending Accounts for medical and dependent care expenses.
Eligible from the first day for 401K, no matching.
A robust package of Marengo-paid insurance coverage, including life insurance, short-term and long-term disability, and parental leave.
20 days of vacation and one personal day, and 64 hours of sick time per year, in addition to 16 company holidays.
TO ALL AGENCIES: Please, no phone calls or emails to any employee of Marengo about our openings. All resumes submitted by search firms/employment agencies to any employee at Marengo via email, the internet or in any form and/or method will be deemed the sole property of Marengo unless such search firms/employment agencies were engaged by Marengo for this position and a valid agreement with Marengo is in place. In the event a candidate who was submitted outside of the Marengo agency engagement process is hired, no fee or payment of any kind will be paid.
Marengo Therapeutics, Inc. is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service or any other class protected by state or federal law.
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Marengo is driven by core values that guide our company’s mission and approach from the inside out: we demonstrate an unparalleled commitment to patients and their loved ones, we are confident in our science and our team, we operate with courage, and we creatively apply deep expertise to new ways of thinking with curiosity and imagination. With an exciting journey ahead and a tremendous opportunity for growth, now is the time to join the Marengo team and impact cancer patient care – are you ready to join the new frontier?
Role: Senior Scientist, In-vivo Pharmacology
Marengo Therapeutics is seeking an experienced and highly motivated In vivo Pharmacologist to join our Immunology research team. As a member of Marengo’s Immunology research team, you will contribute to the characterization of novel T cell-engagers by driving in vivo pharmacological studies to identify clinical candidates.
Please: local candidates only. This is a full-time, lab-based role.
Who are we looking for?
You are an energetic and passionate In vivo Pharmacologist professional who likes to think outside of the box and challenge the norm, and you are passionate about the company’s mission of discovering and developing new medications.
You are an honest, respectful, highly flexible, and resourceful self-starter, results-oriented, and an excellent team player.
You consider yourself a guru in all the critical aspects of In vivo Pharmacology, with a solid understanding of biologics drug discovery, specifically related to the immuno-oncology field.
You can develop trusting relationships to gain support and achieve results at all levels of the organization and across departments (research, development, manufacturing, quality, clinical, and administrative).
You thrive in a dynamic small company environment.
What are we looking for?
Excellent verbal, interpersonal, and written communication skills.
Willingness to constantly expand your horizons with new knowledge, adapt to new ways, and go with the flow.
Ability to determine task priority and maintain established deadlines.
Ability to summarize complex scientific problems into clear strategies and tactics.
What are we offering?
Affiliation with a growing, CARING, and collegial organization.
Being part of a passionate, involved, and cutting-edge Immunology research team.
Exposure to pioneering science and the discovery of drugs to help treat patients in the oncology space.
Responsibilities:
Design, hands-on execution, and interpretation of a wide variety of in vivo pharmacological studies (PK, PD, efficacy, antigen-driven biodistribution, biomarker discovery) to assess drug exposure, target engagement, and anti-tumor activity, drug mechanism of action, and biomarker identification.
Record keeping of experimental data and results and maintain a current and accurate electronic notebook (ELN).
Contribute to in vivo pharmacological plan strategy, optimization and derive actionable biological conclusions and bring new experimental proposals.
Drive and work effectively within cross-functional teams in a matrix environment and implement critical studies to deliver lead/drug candidates to crucial inflection points.
Engage with broader project teams via teamwork to advance portfolio projects.
Provide ideas and perform research to identify and explore new opportunities for developing immune-mediated therapeutics, including continued evolution of the in vivo pharmacology platform at Marengo.
Develop a clear, fully resourced plan for project progression and deliver to agreed timelines.
Contribute to scientific literature through publication and presentation of research results.
Author documents relevant to regulatory submissions.
Manage relationships with off-site vivariums and maintain animal protocol up-to-date.
Education and Experience:
PhD with 6+ years or MS with 10+ years of directly relevant pharmaceutical/biotech industry experience in the field of cancer immunology, T cell biology and/or immuno-oncology, or related discipline with a focus on in vivo pharmacology.
Scientific expertise in in vivo models related to immuno-oncology/oncology, such as murine tumor xenograft, syngeneic, or patient-derived xenograft models.
Deep understanding of biologics drug discovery and early-stage drug development as relates to the critical requirement to build a pharmacology package for candidate drug nomination.
Competencies:
Adaptability : Responds resourcefully, flexibly, and positively when faced with new challenges, transitions, and demands. Willingly and effectively deals with the stress and complexities of various situations. Moves forward productively and optimistically under conditions of change and uncertainty.
Collaboration : Embodies and promotes collaboration and works effectively with others across the organization to achieve goals. Demonstrates proficient cross-company communication, cultural sensitivity, and partnership in interactions with others. Involves others in decisions and plans and credits them for their contributions and accomplishments.
Execution : Drives execution of strategic and operating plans while maintaining operational effectiveness. Conveys a strong sense of urgency around continuous improvement, achieving high-quality results, and accelerating business performance. Addresses problems directly and drives changes necessary to achieve business objectives.
Relationship Building : Establishes and maintains strong relationships internally and externally. Respects and relates well to management, colleagues, peers, and direct reports. Champions a culture of respect, diversity, and inclusion that values and respects individuals. Earns the respect of others through principled leadership, sound business ethics, and authenticity.
Location:
Cambridge, MA (We are located in Lower Cambridge, called Cambridgeport)
When You Join Marengo, You Will Have:
Free parking, Cambridge location reachable by public transportation (Red Line).
Customized and competitive health coverage, including medical offered through BCBS (HMO/PPO), dental, and vision.
Flexible Spending Accounts for medical and dependent care expenses.
Eligible from the first day for 401K, no matching.
A robust package of Marengo-paid insurance coverage, including life insurance, short-term and long-term disability, and parental leave.
20 days of vacation and one personal day, and 64 hours of sick time per year, in addition to 16 company holidays.
TO ALL AGENCIES: Please, no phone calls or emails to any employee of Marengo about our openings. All resumes submitted by search firms/employment agencies to any employee at Marengo via email, the internet or in any form and/or method will be deemed the sole property of Marengo unless such search firms/employment agencies were engaged by Marengo for this position and a valid agreement with Marengo is in place. In the event a candidate who was submitted outside of the Marengo agency engagement process is hired, no fee or payment of any kind will be paid.
Marengo Therapeutics, Inc. is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, disability, genetic information, veteran status, military status, application for military service or any other class protected by state or federal law.
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