Orro
Associate Scientist/Senior Associate Scientist, Platform Biology
Orro, Rochester, New York, United States,
Company Summary:
Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro’s lead program is Alpha-1 Antitrypsin Deficiency (AATD). Korro is based in Cambridge, Massachusetts.We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values -
Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity
form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.Korro Bio is seeking a highly motivated Associate Scientist/Senior Associate Scientist to join the Platform Biology group. This lab-based position will focus on designing, developing, executing, and troubleshooting a variety of biochemical and molecular biology assays to understand ADAR mediated RNA editing machinery, characterize RNA editing efficiency, and downstream consequences. The ideal candidate will have a strong background in biochemistry, molecular or cell biology, demonstrated proficiency in developing, validating, and troubleshooting various biochemical and cell assays with limited supervision. Familiarity with a wide array of technical methods including enzyme kinetic assays, gel electrophoresis, in vitro transcription, dPCR, NGS, western blot, immunofluorescence, FACS, cell culture, and MSD is preferred. The candidate will be a motivated team player with excellent interpersonal and communication skills and be able to balance multiple high-priority tasks in a dynamic and collaborative environment.Key Responsibilities
:Design, execute, troubleshoot, and interpret a variety of biochemical, cellular, and molecular-based assays aiming to understand ADAR mediated RNA editing mechanisms. Evaluate and optimize new assays and techniques. Ability to manage multiple projects efficiently.Participate in the development, validation, and scaling up of novel assays.Analyze and interpret data critically, document findings accurately, and communicate findings effectively.Collaborate productively within a multidisciplinary team to advance project goals.Required Qualifications
:MS (3+ years’ experience)/BS (5+ years’ experience) in Biochemistry, Molecular or Cell Biology or related discipline.Broad experience in the application of biochemical, biophysical & cell-based techniques such as Western blotting, plate-based enzyme assays, RNA/DNA extraction and QC, PCR, probe-based qPCR and dPCR, gel electrophoresis, and EMSA, in vitro transcription, mammalian cell culture, and transfections.Proficiency in utilizing software such as GraphPad Prism, Electronic Lab Notebooks, Microsoft Office, etc. for data analysis and figure generation is essential.The ability to learn and implement new techniques and adapt rapidly.Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a dynamic and highly collaborative environment.Exceptional attention to detail, excellent organizational and record-keeping skills.Track record of managing several projects and timely execution.Other Knowledge, Experience or Skills recommended
:Background in oligonucleotide therapeutics is preferred.Familiarity with the use of lab automation.Experience with SPR or BLI platforms is a plus.Benefits:
Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account, a company-funded health savings account, and free parking.
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Korro is a biopharmaceutical company focused on developing a new class of genetic medicines for both rare and highly prevalent diseases using its proprietary RNA editing platform. Korro is generating a portfolio of differentiated programs that are designed to harness the body’s natural RNA editing process to effect a precise yet transient single base edit. By editing RNA instead of DNA, Korro is expanding the reach of genetic medicines by delivering additional precision and tunability, which has the potential for increased specificity and improved long-term tolerability. Using an oligonucleotide-based approach, Korro expects to bring its medicines to patients by leveraging its proprietary platform with precedented delivery modalities, manufacturing know-how, and established regulatory pathways of approved oligonucleotide drugs. Korro’s lead program is Alpha-1 Antitrypsin Deficiency (AATD). Korro is based in Cambridge, Massachusetts.We are collaborative and united by a common mission. We are building a company with extraordinary people with an audacious vision to create transformative genetic medicines for prevalent diseases. Our values -
Rewrite the future, On the Cutting Edge, Better Together, Dynamically Different, Kindness and Integrity
form the fabric of the organization. They are reinforced daily and serve as key dimensions in the hiring process to help us ensure that Korro is a magnet for outstanding talent and a great place to work. Join us as we redefine what's possible in genetic medicine and work to make a lasting impact on human health.Korro Bio is seeking a highly motivated Associate Scientist/Senior Associate Scientist to join the Platform Biology group. This lab-based position will focus on designing, developing, executing, and troubleshooting a variety of biochemical and molecular biology assays to understand ADAR mediated RNA editing machinery, characterize RNA editing efficiency, and downstream consequences. The ideal candidate will have a strong background in biochemistry, molecular or cell biology, demonstrated proficiency in developing, validating, and troubleshooting various biochemical and cell assays with limited supervision. Familiarity with a wide array of technical methods including enzyme kinetic assays, gel electrophoresis, in vitro transcription, dPCR, NGS, western blot, immunofluorescence, FACS, cell culture, and MSD is preferred. The candidate will be a motivated team player with excellent interpersonal and communication skills and be able to balance multiple high-priority tasks in a dynamic and collaborative environment.Key Responsibilities
:Design, execute, troubleshoot, and interpret a variety of biochemical, cellular, and molecular-based assays aiming to understand ADAR mediated RNA editing mechanisms. Evaluate and optimize new assays and techniques. Ability to manage multiple projects efficiently.Participate in the development, validation, and scaling up of novel assays.Analyze and interpret data critically, document findings accurately, and communicate findings effectively.Collaborate productively within a multidisciplinary team to advance project goals.Required Qualifications
:MS (3+ years’ experience)/BS (5+ years’ experience) in Biochemistry, Molecular or Cell Biology or related discipline.Broad experience in the application of biochemical, biophysical & cell-based techniques such as Western blotting, plate-based enzyme assays, RNA/DNA extraction and QC, PCR, probe-based qPCR and dPCR, gel electrophoresis, and EMSA, in vitro transcription, mammalian cell culture, and transfections.Proficiency in utilizing software such as GraphPad Prism, Electronic Lab Notebooks, Microsoft Office, etc. for data analysis and figure generation is essential.The ability to learn and implement new techniques and adapt rapidly.Excellent interpersonal and collaborative skills, and the ability to work independently and effectively in a dynamic and highly collaborative environment.Exceptional attention to detail, excellent organizational and record-keeping skills.Track record of managing several projects and timely execution.Other Knowledge, Experience or Skills recommended
:Background in oligonucleotide therapeutics is preferred.Familiarity with the use of lab automation.Experience with SPR or BLI platforms is a plus.Benefits:
Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance, a dependent care flexible spending account, a company-funded health savings account, and free parking.
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