Bristol Myers Squibb
Senior Associate Scientist Molecular Biology, Discovery Cardiovascular
Bristol Myers Squibb, Brisbane, California, United States, 94005
Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.
BMS Overview
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Immunology and Cardiovascular Thematic Research Center (TRC) at BMS is one of the fundamental Research and Early Development (R&ED) units delivering therapeutics to patients. Our mission is to create transformative medicines of tomorrow based on the cutting-edge science of today. We leverage BMS's internal engine of invention that includes industry-leading expertise in small molecule chemistry, protein biotherapeutics, cell therapy, protein degradation, nucleic acids, and other therapeutic modalities. We work closely with our R&ED colleagues in clinical and non-clinical development, project leadership, translational medicine, and informatics to advance therapies based on a deep understanding of causal human biology. Further, we collaborate across the biopharmaceutical ecosystem to establish partnerships that complement our internal expertise.
Position Responsibilities
BMS seeks a highly motivated, creative, and collaborative Molecular and/or Cellular Biologist to join our Cardiovascular Discovery Biology team. This person will support research efforts to discover and develop novel therapies for the treatment of serious cardiovascular disease, including genetic cardiomyopathies and heart failure. The successful candidate will work collaboratively with teams in Biochemistry/Biophysics, Cell Biology, Lead Discovery and Optimization (LDO) to support BMS's Cardiovascular Research and Early Discovery efforts. Research will be aimed at establishment and validation of cellular models for novel therapeutic targets, and development of cellular assays for high throughput screening. The candidate will be a highly motivated individual with extensive experience in iPSC handling and cardiomyogenic differentiation, molecular and cellular biology techniques, gene expression modulation and cellular assay development. Previous experience with cell line engineering, and HTS screening methodologies will be highly desirable. This position provides an exciting opportunity to be a part of and grow with a key discovery function within the CV Discovery Biology Department.
Perform standard cell culture support including maintenance and cardiogenic differentiation of iPSC linesSupport iPSC-CM differentiation and manufacturing towards generating disease models and supporting screening campaigns.Broad range of molecular and cellular biology methods to interrogate and validate iPSC disease models and novel therapeutic targets/hypotheses.Work closely with our discovery biology and LDO teams to develop and optimize HTS cell-based biological and validation assays.Support gene-editing of mammalian cells, including iPSCs, towards generating disease models.Prepare reports, publications and present to senior management and cross-functional teams.Support some lab management duties as assigned.Basic Qualifications:
Bachelor's Degree
4+ years of industry experience
OR
Master's Degree
2+ years of industry experience
Preferred Qualifications:
Extensive hands-on experience in cell biology and cellular assays including iPSC line maintenance and cardiogenic differentiation as well as functional assessment of healthy and diseased iPSC-CMs is highly desirable.Strong experience with cellular and molecular biology methodologies including cytotoxicity assays, gene expression analysis, RNAi technologies and immunocytochemistry.Hands on experience with methodologies for functional assessment of iPSC-CMs (contractility, electrophysiology, metabolic properties) is strongly preferredExperience with CRISPR/Cas9 gene editing technologies is desirable.For CA, based candidates only: The starting compensation for this job is a range from $83,000 - $104,000, plus incentive cash and stock opportunities (based on eligibility).
The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.
Final, individual compensation will be decided based on demonstrated experience.
At BMS, our employees are committed to the following values:
Integrity
- We demonstrate ethics, integrity, and quality in everything we do for patients, customers, and colleagues
Innovation
- We pursue disruptive and bold solutions for patients
Urgency
- We move together with speed and quality because patients are waiting
Passion
- Our dedication to learning and excellence helps us to deliver exceptional results
Accountability
- We all own BMS' success and strive to be transparent and deliver on our commitments
Inclusion
- We embrace diversity and foster an environment where we can all work together at our full potential
Why You Should Apply
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.#J-18808-Ljbffr
BMS Overview
When you join BMS, you are joining a diverse, high-achieving team united by a common mission.
The Immunology and Cardiovascular Thematic Research Center (TRC) at BMS is one of the fundamental Research and Early Development (R&ED) units delivering therapeutics to patients. Our mission is to create transformative medicines of tomorrow based on the cutting-edge science of today. We leverage BMS's internal engine of invention that includes industry-leading expertise in small molecule chemistry, protein biotherapeutics, cell therapy, protein degradation, nucleic acids, and other therapeutic modalities. We work closely with our R&ED colleagues in clinical and non-clinical development, project leadership, translational medicine, and informatics to advance therapies based on a deep understanding of causal human biology. Further, we collaborate across the biopharmaceutical ecosystem to establish partnerships that complement our internal expertise.
Position Responsibilities
BMS seeks a highly motivated, creative, and collaborative Molecular and/or Cellular Biologist to join our Cardiovascular Discovery Biology team. This person will support research efforts to discover and develop novel therapies for the treatment of serious cardiovascular disease, including genetic cardiomyopathies and heart failure. The successful candidate will work collaboratively with teams in Biochemistry/Biophysics, Cell Biology, Lead Discovery and Optimization (LDO) to support BMS's Cardiovascular Research and Early Discovery efforts. Research will be aimed at establishment and validation of cellular models for novel therapeutic targets, and development of cellular assays for high throughput screening. The candidate will be a highly motivated individual with extensive experience in iPSC handling and cardiomyogenic differentiation, molecular and cellular biology techniques, gene expression modulation and cellular assay development. Previous experience with cell line engineering, and HTS screening methodologies will be highly desirable. This position provides an exciting opportunity to be a part of and grow with a key discovery function within the CV Discovery Biology Department.
Perform standard cell culture support including maintenance and cardiogenic differentiation of iPSC linesSupport iPSC-CM differentiation and manufacturing towards generating disease models and supporting screening campaigns.Broad range of molecular and cellular biology methods to interrogate and validate iPSC disease models and novel therapeutic targets/hypotheses.Work closely with our discovery biology and LDO teams to develop and optimize HTS cell-based biological and validation assays.Support gene-editing of mammalian cells, including iPSCs, towards generating disease models.Prepare reports, publications and present to senior management and cross-functional teams.Support some lab management duties as assigned.Basic Qualifications:
Bachelor's Degree
4+ years of industry experience
OR
Master's Degree
2+ years of industry experience
Preferred Qualifications:
Extensive hands-on experience in cell biology and cellular assays including iPSC line maintenance and cardiogenic differentiation as well as functional assessment of healthy and diseased iPSC-CMs is highly desirable.Strong experience with cellular and molecular biology methodologies including cytotoxicity assays, gene expression analysis, RNAi technologies and immunocytochemistry.Hands on experience with methodologies for functional assessment of iPSC-CMs (contractility, electrophysiology, metabolic properties) is strongly preferredExperience with CRISPR/Cas9 gene editing technologies is desirable.For CA, based candidates only: The starting compensation for this job is a range from $83,000 - $104,000, plus incentive cash and stock opportunities (based on eligibility).
The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.
Final, individual compensation will be decided based on demonstrated experience.
At BMS, our employees are committed to the following values:
Integrity
- We demonstrate ethics, integrity, and quality in everything we do for patients, customers, and colleagues
Innovation
- We pursue disruptive and bold solutions for patients
Urgency
- We move together with speed and quality because patients are waiting
Passion
- Our dedication to learning and excellence helps us to deliver exceptional results
Accountability
- We all own BMS' success and strive to be transparent and deliver on our commitments
Inclusion
- We embrace diversity and foster an environment where we can all work together at our full potential
Why You Should Apply
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.#J-18808-Ljbffr