Pfizer, S.A. de C.V
Senior Scientist (PhD) - Immunology/T-Cell Biology
Pfizer, S.A. de C.V, Frankfort, Kentucky, United States,
Senior Scientist (PhD) - Immunology/T-Cell Biology
We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.Pfizer's Oncology Research Unit (ORU) in La Jolla, California, is seeking a Senior Scientist (PhD) to join the Post-Candidate Research (PCR) group, focused on translating basic discoveries in the field of immune oncology (IO) into novel therapeutics.The Senior Scientist will serve as a technical subject matter expert and scientific contributor, working with a collaborative team of motivated and scientifically rigorous scientists to advance our clinical and pre-clinical drug programs in the field of immune oncology, focused on large molecule (biologic) therapeutics. The ideal candidate will have a strong background in immunology and cancer biology, with deep understanding of emerging field technologies and novel approaches to probe their mechanism of action. The candidate will execute translational research to evaluate target biology, understand pharmacological mechanism(s) of action, evaluate novel drug combination strategies and mechanisms of resistance. A successful candidate will demonstrate experience with primary immune cell assays, developing novel methods to rigorously test hypothesis, and a proven track record of productivity as evidenced by scientific initiative and creativity or first author publications in scientific journals.Role Responsibilities
Independently design, execute and analyze/interpret experiments to evaluate mechanism of action, elucidate mechanisms of resistance, and identify rational drug combinations that will advance preclinical and clinical stage IO programsParticipate at the project team level as a subject matter expert and effectively collaborate with other members of the Oncology Research Unit, including early research and discovery biology, computational biology, in vivo pharmacology, toxicology and drug pharmacokinetics teamsProactively seek out novel methods in the literature and incorporate learnings to progress preclinical research and develop new experimental ways of testing hypothesesPresent research results and methodologies at routine meetings with immediate supervisor and/or project leader, project team meetings and other research forumsForecast and plan resource requirements to meet the research goals as part of the project teamRecord experimental protocols/results in detail and may write technical reports for regulatory filingsSupervise and mentor junior colleagues in experimental assay design, execution, and analysisMay occasionally engage and work with external collaborations and Contract Research Organizations (CROs)Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific developmentQualifications
Must-Have
PhD, in cancer biology, tumor immunology, immunology or a related field with 2+ years of relevant postdoctoral experience in an academic or pharmaceutical/biotech environmentA desire to continue in a laboratory-focused role and develop innovative methods to evaluate biological therapeutics for their impact on target biology and immune modulationExpertise in tumor biology or immunology as evidenced by publication in peer-reviewed journalsDemonstrated proficiency in a wide range of immune assays and cellular techniques including mammalian cell culture, multicolor flow cytometry/FACS to immunophenotype murine and human cells from blood and tissues, and cytokine measurements from serum/plasma (MSD, Luminex, ELISA)Strong knowledge of T cell biology with technical expertise in T cell-based functional assays (e.g. activation, differentiation, proliferation)Strong ability to multi-task and work independently and efficiently in a fast-paced, highly collaborative in a diverse team environment with excellent communication skills and excellent leadership skillsNice-to-Have
Previous industry experience with target validation or evaluating drug combinations and a track record of success in immune-oncology drug discoveryExperience in writing technical study reports in support of regulatory filingsPrior experience in mentoring junior scientistsExtensive experience in cancer research, tumor microenvironment biology, immunology, or related fields, and a desire to continue in a laboratory-focused role
Work Location Assignment: On PremiseThe annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.Relocation assistance may be available based on business needs and/or eligibility.
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We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.Pfizer's Oncology Research Unit (ORU) in La Jolla, California, is seeking a Senior Scientist (PhD) to join the Post-Candidate Research (PCR) group, focused on translating basic discoveries in the field of immune oncology (IO) into novel therapeutics.The Senior Scientist will serve as a technical subject matter expert and scientific contributor, working with a collaborative team of motivated and scientifically rigorous scientists to advance our clinical and pre-clinical drug programs in the field of immune oncology, focused on large molecule (biologic) therapeutics. The ideal candidate will have a strong background in immunology and cancer biology, with deep understanding of emerging field technologies and novel approaches to probe their mechanism of action. The candidate will execute translational research to evaluate target biology, understand pharmacological mechanism(s) of action, evaluate novel drug combination strategies and mechanisms of resistance. A successful candidate will demonstrate experience with primary immune cell assays, developing novel methods to rigorously test hypothesis, and a proven track record of productivity as evidenced by scientific initiative and creativity or first author publications in scientific journals.Role Responsibilities
Independently design, execute and analyze/interpret experiments to evaluate mechanism of action, elucidate mechanisms of resistance, and identify rational drug combinations that will advance preclinical and clinical stage IO programsParticipate at the project team level as a subject matter expert and effectively collaborate with other members of the Oncology Research Unit, including early research and discovery biology, computational biology, in vivo pharmacology, toxicology and drug pharmacokinetics teamsProactively seek out novel methods in the literature and incorporate learnings to progress preclinical research and develop new experimental ways of testing hypothesesPresent research results and methodologies at routine meetings with immediate supervisor and/or project leader, project team meetings and other research forumsForecast and plan resource requirements to meet the research goals as part of the project teamRecord experimental protocols/results in detail and may write technical reports for regulatory filingsSupervise and mentor junior colleagues in experimental assay design, execution, and analysisMay occasionally engage and work with external collaborations and Contract Research Organizations (CROs)Contribute to building a culture that embraces scientific excellence, urgency, partnerships with key stakeholders, continuous learning and improvement, increasing technical skill base and cancer biology expertise; take a proactive role in personal growth and scientific developmentQualifications
Must-Have
PhD, in cancer biology, tumor immunology, immunology or a related field with 2+ years of relevant postdoctoral experience in an academic or pharmaceutical/biotech environmentA desire to continue in a laboratory-focused role and develop innovative methods to evaluate biological therapeutics for their impact on target biology and immune modulationExpertise in tumor biology or immunology as evidenced by publication in peer-reviewed journalsDemonstrated proficiency in a wide range of immune assays and cellular techniques including mammalian cell culture, multicolor flow cytometry/FACS to immunophenotype murine and human cells from blood and tissues, and cytokine measurements from serum/plasma (MSD, Luminex, ELISA)Strong knowledge of T cell biology with technical expertise in T cell-based functional assays (e.g. activation, differentiation, proliferation)Strong ability to multi-task and work independently and efficiently in a fast-paced, highly collaborative in a diverse team environment with excellent communication skills and excellent leadership skillsNice-to-Have
Previous industry experience with target validation or evaluating drug combinations and a track record of success in immune-oncology drug discoveryExperience in writing technical study reports in support of regulatory filingsPrior experience in mentoring junior scientistsExtensive experience in cancer research, tumor microenvironment biology, immunology, or related fields, and a desire to continue in a laboratory-focused role
Work Location Assignment: On PremiseThe annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site – U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States.Relocation assistance may be available based on business needs and/or eligibility.
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