AbbVie
Scientist I Biologics Drug Substance Development Cell Culture Development
AbbVie, South San Francisco, California, us, 94083
Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at
www.abbvie.com . Follow @abbvie on
Twitter ,
Facebook ,
Instagram ,
YouTube
and
LinkedIn .
DESCRIPTION:
The Cell Culture Development Group in South San Francisco, CA is seeking a Scientist I to join a talented and collaborative team to develop cell culture processes for GMP applications.
In this position, you will perform cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies.
KEY RESPONSIBILITIES:
Design and execute robust and scalable cell culture processes in ambr250, 2L, 50L, 200L 500L single use bioreactors
Design scalable inoculum expansion and master cell bank generation processes
Design and execute small scale and pilot scale depth filtration and centrifugation primary recovery processes
Participate in the tech transfer of Master cell bank generation, cell culture and primary recovery processes to the GMP manufacturing facilities in Worcester, MA
Provide person-in-plant support at the GMP manufacturing facility
Represent the cell culture development group in cross-functional meetings and collaborate closely with cell line, purification, analytical and formulation development leads to meet project timelines
Author and review technical reports, GMP campaign summary reports and relevant sections in regulatory filings
Actively seek out opportunities to optimize our platform or enhance our understanding of cell culture processes
Contribute to publishing or presenting scientific findings in in-house or external conferences
Display effective organization, verbal written communication skills, and adherence to good documentation practices
Qualifications
Scientific degree in chemical engineering, bioengineering, biotechnology, or a related field, ≥ 2 years for M.S., or ≥ 5 years for B.S.
Proficient in aseptic techniques
Experienced in developing and executing mammalian suspension cell culture processes in shake flasks, ambr250 and 2L bioreactors
Experience with perfusion technology, especially Alternating Tangential flow filtration (ATF)
Strong understanding of mammalian cell and molecular biology and cell culture bioprocess engineering concepts
Strong attention to detail; active and quick learner; able to change course quickly as needed, raises the bar and is never satisfied with the status quo; open to suggestions and embraces the ideas of others; collaborative actively builds relationships with others
Experienced in technical report authoring and reviewing
Proficient with Microsoft Office software (Word, Excel, and Powerpoint) and statistical modelling software (JMP, SIMCA, Minitab, Design Expert)
Preferred:
Experience with programming (VBA, Python, Javascript, C++)
Experience with authoring peer-reviewed publications, technical reports, regulatory documents, and/or presentations at conferences
Have a strong understanding of statistical analysis and design of experiments (DOE)
Salary:
$71,000 - $134,500
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AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at
www.abbvie.com . Follow @abbvie on
Twitter ,
Facebook ,
Instagram ,
YouTube
and
LinkedIn .
DESCRIPTION:
The Cell Culture Development Group in South San Francisco, CA is seeking a Scientist I to join a talented and collaborative team to develop cell culture processes for GMP applications.
In this position, you will perform cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel biotherapeutics into human clinical studies.
KEY RESPONSIBILITIES:
Design and execute robust and scalable cell culture processes in ambr250, 2L, 50L, 200L 500L single use bioreactors
Design scalable inoculum expansion and master cell bank generation processes
Design and execute small scale and pilot scale depth filtration and centrifugation primary recovery processes
Participate in the tech transfer of Master cell bank generation, cell culture and primary recovery processes to the GMP manufacturing facilities in Worcester, MA
Provide person-in-plant support at the GMP manufacturing facility
Represent the cell culture development group in cross-functional meetings and collaborate closely with cell line, purification, analytical and formulation development leads to meet project timelines
Author and review technical reports, GMP campaign summary reports and relevant sections in regulatory filings
Actively seek out opportunities to optimize our platform or enhance our understanding of cell culture processes
Contribute to publishing or presenting scientific findings in in-house or external conferences
Display effective organization, verbal written communication skills, and adherence to good documentation practices
Qualifications
Scientific degree in chemical engineering, bioengineering, biotechnology, or a related field, ≥ 2 years for M.S., or ≥ 5 years for B.S.
Proficient in aseptic techniques
Experienced in developing and executing mammalian suspension cell culture processes in shake flasks, ambr250 and 2L bioreactors
Experience with perfusion technology, especially Alternating Tangential flow filtration (ATF)
Strong understanding of mammalian cell and molecular biology and cell culture bioprocess engineering concepts
Strong attention to detail; active and quick learner; able to change course quickly as needed, raises the bar and is never satisfied with the status quo; open to suggestions and embraces the ideas of others; collaborative actively builds relationships with others
Experienced in technical report authoring and reviewing
Proficient with Microsoft Office software (Word, Excel, and Powerpoint) and statistical modelling software (JMP, SIMCA, Minitab, Design Expert)
Preferred:
Experience with programming (VBA, Python, Javascript, C++)
Experience with authoring peer-reviewed publications, technical reports, regulatory documents, and/or presentations at conferences
Have a strong understanding of statistical analysis and design of experiments (DOE)
Salary:
$71,000 - $134,500
#J-18808-Ljbffr