AbbVie
Associate Scientist IIScientist I Cell Culture Development
AbbVie, South San Francisco, California, us, 94083
Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at
www.abbvie.com . Follow @abbvie on
Twitter ,
Facebook ,
Instagram ,
YouTube
and
LinkedIn .
AbbVie Bay Area (ABA) in South San Francisco is focused on the discovery and development of novel oncology, immunology, and infectious disease therapeutics. About 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work at ABA. They combine their expertise in oncology, immunology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel biotherapeutics.
Job Description
We are seeking an Associate Scientist II or Scientist I to join a talented and collaborative team to develop cell culture processes for pre-clinical and clinical manufacture. In this position, the candidate will perform media preparation, cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel therapeutics into pre-clinical and clinical studies.
Responsibilities:
Develop cell culture processes from vial thaw to primary recovery for INDa-enabling toxicology studies and Phase I GMP manufacture
Use scientific and engineering principles to scale up cell culture processes from ambr250 and/or 2L benchtop scale up to the 4000L scale
Use scientific and engineering principles to scale up primary recovery processes
Collaborate closely with project leads from the Cell Line Development and Purification Development groups to meet dynamic project timelines
Support the tech transfer of master cell banking, cell culture, and primary recovery processes for Phase I GMP manufacture
Author and review technical development reports, GMP campaign summary reports and relevant CMC sections for regulatory submissions
Lead and/or support the continuous improvement of business processes in the Cell Culture group
Develop innovative technologies and enhance our cell culture process understanding
Present and/or publish scientific findings at internal forums, external conferences, and/or peer-reviewed journals
Qualifications
Position will be hired based on level of experience:
Associate Scientist II:
Bachelor’s Degree, or equivalent education, with typically 3 or more years’ experience or Master’s Degree or equivalent education (no additional experience)
Scientist I:
Bachelor of Science with at least 5 years of industrial CHO cell culture experience or Master of Science with at least 2 years of industrial CHO cell culture experience
Proficient in aseptic technique in a biosafety cabinet
Proficient in vial thaw, banking cell lines, and seed train scale up
Experienced in using cell counters, blood gas analyzers, metabolite analyzers and osmometers
Has experience in executing cell culture processes in the Ambr 250 and 2L bioreactors
Basic understanding of primary harvest processes
Has first-principles understanding of CHO metabolism, cellular transport, gas transport, and enzyme kinetics
With some assistance, be able to design, execute, and interpret laboratory experiments to answer specific scientific questions
Has excellent attention to detail and the ability to keep detailed written records in an electronic lab notebook or batch record
Proficient with Microsoft Office software (MS Excel, Word, PowerPoint, Outlook, Teams)
Has strong verbal communications skills and writing skills to clearly articulate messages and scientific data to a variety of technical and non-technical audiences
Forward-thinking and able to contribute to scientific/technical discussions
Is a team player: willing to assist lab mates as needed and to work over the weekend for 1-2 hours, once every 6 weeks
Preferred:
Hands on experience with media preparation
Experience with transient transfection in CHO/HEK cells
Experience with the setup and operations of pilot scale (50L to 500L) single use bioreactors, continuous disk stack centrifuge, and depth filtration
Experience with creating and analyzing Design of Experiments
Experienced in programming (VBA, Python, Java, etc)
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
US & Puerto Rico only - to learn more, visit
https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
https://www.abbvie.com/join-us/reasonable-accommodations.html
Salary: $71,000 - $134,500
#J-18808-Ljbffr
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at
www.abbvie.com . Follow @abbvie on
Twitter ,
Facebook ,
Instagram ,
YouTube
and
LinkedIn .
AbbVie Bay Area (ABA) in South San Francisco is focused on the discovery and development of novel oncology, immunology, and infectious disease therapeutics. About 1,000 AbbVie scientists, clinicians, and product developers with strong entrepreneurial roots work at ABA. They combine their expertise in oncology, immunology, stem cells, and cell-signaling with their knowledge of bispecific antibodies, antibody-drug conjugates (ADCs), and covalent-inhibitor technologies to discover and develop novel biotherapeutics.
Job Description
We are seeking an Associate Scientist II or Scientist I to join a talented and collaborative team to develop cell culture processes for pre-clinical and clinical manufacture. In this position, the candidate will perform media preparation, cell culture process development, scale-up, and technology transfer activities in a well-supported and dynamic environment to help advance novel therapeutics into pre-clinical and clinical studies.
Responsibilities:
Develop cell culture processes from vial thaw to primary recovery for INDa-enabling toxicology studies and Phase I GMP manufacture
Use scientific and engineering principles to scale up cell culture processes from ambr250 and/or 2L benchtop scale up to the 4000L scale
Use scientific and engineering principles to scale up primary recovery processes
Collaborate closely with project leads from the Cell Line Development and Purification Development groups to meet dynamic project timelines
Support the tech transfer of master cell banking, cell culture, and primary recovery processes for Phase I GMP manufacture
Author and review technical development reports, GMP campaign summary reports and relevant CMC sections for regulatory submissions
Lead and/or support the continuous improvement of business processes in the Cell Culture group
Develop innovative technologies and enhance our cell culture process understanding
Present and/or publish scientific findings at internal forums, external conferences, and/or peer-reviewed journals
Qualifications
Position will be hired based on level of experience:
Associate Scientist II:
Bachelor’s Degree, or equivalent education, with typically 3 or more years’ experience or Master’s Degree or equivalent education (no additional experience)
Scientist I:
Bachelor of Science with at least 5 years of industrial CHO cell culture experience or Master of Science with at least 2 years of industrial CHO cell culture experience
Proficient in aseptic technique in a biosafety cabinet
Proficient in vial thaw, banking cell lines, and seed train scale up
Experienced in using cell counters, blood gas analyzers, metabolite analyzers and osmometers
Has experience in executing cell culture processes in the Ambr 250 and 2L bioreactors
Basic understanding of primary harvest processes
Has first-principles understanding of CHO metabolism, cellular transport, gas transport, and enzyme kinetics
With some assistance, be able to design, execute, and interpret laboratory experiments to answer specific scientific questions
Has excellent attention to detail and the ability to keep detailed written records in an electronic lab notebook or batch record
Proficient with Microsoft Office software (MS Excel, Word, PowerPoint, Outlook, Teams)
Has strong verbal communications skills and writing skills to clearly articulate messages and scientific data to a variety of technical and non-technical audiences
Forward-thinking and able to contribute to scientific/technical discussions
Is a team player: willing to assist lab mates as needed and to work over the weekend for 1-2 hours, once every 6 weeks
Preferred:
Hands on experience with media preparation
Experience with transient transfection in CHO/HEK cells
Experience with the setup and operations of pilot scale (50L to 500L) single use bioreactors, continuous disk stack centrifuge, and depth filtration
Experience with creating and analyzing Design of Experiments
Experienced in programming (VBA, Python, Java, etc)
Additional Information
Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law:
The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location, and we may ultimately pay more or less than the posted range. This range may be modified in the future.
We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees.
This job is eligible to participate in our short-term incentive programs.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
US & Puerto Rico only - to learn more, visit
https://www.abbvie.com/join-us/equal-employment-opportunity-employer.html
US & Puerto Rico applicants seeking a reasonable accommodation, click here to learn more:
https://www.abbvie.com/join-us/reasonable-accommodations.html
Salary: $71,000 - $134,500
#J-18808-Ljbffr