Quest Diagnostics Incorporated
Validation Scientist (Drug Monitoring)
Quest Diagnostics Incorporated, Irving, Texas, United States, 75084
This position manages analytical projects in R & D, supervises projects from the assay design, validation and implementation. This position also manages special projects in R & D and operates as a technical consultant in maintaining current testing reliability including diagnosing test failures and implementing corrective action. The incumbent assists in the development and maintenance of the R & D Department.
Responsibilities:
Coordinates and provides bench level supervision of projects for R & D using HPLC, GC, GC/MS, ICP/MS, and LC-MS/MS, and any associated analytical techniques as directed by the Science Manager and/or Science Director.Coordinates the implementation of new procedures within the department and with other support departments.Familiarizes with new models of instrumentation and new analytical techniques to assess their operational potentials to be implemented in the laboratory.Performs statistical analysis, validation, and laboratory information system interface testing of new methods. Provides written summaries of work to be used for method documentation.Trains staff in new methods both in technical and instrumental aspects.Manages special projects with the duties of coordination of resources and personnel.Serves as a resource for HPLC, GC, GC/MS, LC-MS/MS, ICP/MS, and automated liquid handling system related questions.Writes technical proposals soliciting drug and toxin analysis services and contributes as requested to the business proposals for these solicitations.Maintains present testing reliability including diagnosing test failures (instrumental and chemical) and implementing corrective action.Provides technical understanding of analytical techniques with particular emphasis on instrumental methods of analysis.Responsible for informing the appropriate supervisor of all problems associated with the proper performance of test procedures.Maintains accurate records of all corrective and preventive maintenance to satisfy licensing requirements.Actively supports and complies with laboratory policies and procedures.Other duties as assigned. This is not an exhaustive list of all duties and responsibilities, but rather a general description of work performed by the position.
Required Work Experience:
A minimum of (4) years of forensic/Clinical Toxicology/Drug Monitoring or forensic Chemistry laboratory experience, including at least 2 years of data certification or method optimization and validation experience, with extensive troubleshooting experience in following analytical techniques: HPLC, Gas Chromatography, GC/MS, ICP/MS and/or LC-MS/MS, sample preparation, automated liquid handling system (e.g. Hamilton) required.Advanced troubleshooting of LC-MS/MS and Automated Liquid Handling instrumentation including, but not limited to:Ability to diagnose/recognize need for pump seal replacement. Ability to replace pump seals.Ability to diagnose/recognize need for injector rotor seal replacement. Ability to replace injector rotor seal.Ability to diagnose/recognize low instrument signal. Ability to clean a Q-jet to improve instrument signal.Ability to change pump check valves.Ability to examine, discern, or understand programming language or logics of methods installed on automated liquid handling systems.Ability to clearly and effectively communicate diagnoses and root causes of defects between vendor service engineers and the laboratory.Preferred Work Experience:
Experience with creating Excel macros and/or utilizing analytic tools (e.g., Excel, Tableau, PowerBI).Physical and Mental Requirements:
Ability to sit and/or stand for long periods.Skills:
Proficient in Microsoft Office Suites products: Excel, PowerPoint, Word.Ability to see projects to completion.Ability to manage time and details.Good verbal and written skills required.Interpersonal skills necessary to deal courteously and effectively with supervisors, co-workers and clients.Education:
Bachelor's Degree (Required)Master's Degree
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Responsibilities:
Coordinates and provides bench level supervision of projects for R & D using HPLC, GC, GC/MS, ICP/MS, and LC-MS/MS, and any associated analytical techniques as directed by the Science Manager and/or Science Director.Coordinates the implementation of new procedures within the department and with other support departments.Familiarizes with new models of instrumentation and new analytical techniques to assess their operational potentials to be implemented in the laboratory.Performs statistical analysis, validation, and laboratory information system interface testing of new methods. Provides written summaries of work to be used for method documentation.Trains staff in new methods both in technical and instrumental aspects.Manages special projects with the duties of coordination of resources and personnel.Serves as a resource for HPLC, GC, GC/MS, LC-MS/MS, ICP/MS, and automated liquid handling system related questions.Writes technical proposals soliciting drug and toxin analysis services and contributes as requested to the business proposals for these solicitations.Maintains present testing reliability including diagnosing test failures (instrumental and chemical) and implementing corrective action.Provides technical understanding of analytical techniques with particular emphasis on instrumental methods of analysis.Responsible for informing the appropriate supervisor of all problems associated with the proper performance of test procedures.Maintains accurate records of all corrective and preventive maintenance to satisfy licensing requirements.Actively supports and complies with laboratory policies and procedures.Other duties as assigned. This is not an exhaustive list of all duties and responsibilities, but rather a general description of work performed by the position.
Required Work Experience:
A minimum of (4) years of forensic/Clinical Toxicology/Drug Monitoring or forensic Chemistry laboratory experience, including at least 2 years of data certification or method optimization and validation experience, with extensive troubleshooting experience in following analytical techniques: HPLC, Gas Chromatography, GC/MS, ICP/MS and/or LC-MS/MS, sample preparation, automated liquid handling system (e.g. Hamilton) required.Advanced troubleshooting of LC-MS/MS and Automated Liquid Handling instrumentation including, but not limited to:Ability to diagnose/recognize need for pump seal replacement. Ability to replace pump seals.Ability to diagnose/recognize need for injector rotor seal replacement. Ability to replace injector rotor seal.Ability to diagnose/recognize low instrument signal. Ability to clean a Q-jet to improve instrument signal.Ability to change pump check valves.Ability to examine, discern, or understand programming language or logics of methods installed on automated liquid handling systems.Ability to clearly and effectively communicate diagnoses and root causes of defects between vendor service engineers and the laboratory.Preferred Work Experience:
Experience with creating Excel macros and/or utilizing analytic tools (e.g., Excel, Tableau, PowerBI).Physical and Mental Requirements:
Ability to sit and/or stand for long periods.Skills:
Proficient in Microsoft Office Suites products: Excel, PowerPoint, Word.Ability to see projects to completion.Ability to manage time and details.Good verbal and written skills required.Interpersonal skills necessary to deal courteously and effectively with supervisors, co-workers and clients.Education:
Bachelor's Degree (Required)Master's Degree
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