AbbVie
Scientist I in vitro ADMETransporter Sciences
AbbVie, South San Francisco, California, us, 94083
Company Description
AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at
www.abbvie.com . Follow @abbvie on
Twitter ,
Facebook ,
Instagram ,
YouTube
and
LinkedIn .
Job Description
The Quantitative, Translational, and ADME Sciences (QTAS) department in AbbVie Bay Area (ABA), CA is seeking a highly motivated transporter scientist to join the In Vitro ADME Science (IVAS) group. The QTAS department supports Discovery and Development Projects by generating in vitro ADME data, pharmacokinetics characterization, prediction of human efficacious dose/pk, drug-drug interactions (DDI) and in vitro to in vivo extrapolations towards the development of clinical candidates. QTAS works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, clinical pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings. In this role, the candidate will be responsible for generating in vitro transporter related data and supporting early discovery to late-stage pipeline.
Core Job Responsibilities:
Conducting in vitro transporter experiments using a wide range of in vitro systems such as recombinant transporter and primary cell lines to support pipeline projects in a timely manner
Cell culture, storage (maintain cell repository-recombinant and primary) and work closely with team members
Conducting primary hepatocytes-based in vitro uptake experiments
Conducting HT-screening for potential inhibition of uptake transporters
Analyzing experimental data and maintaining accurate and comprehensible study documentation in real time
Taking part in scientific development goals to improve data quality, capacity, and introducing new tools and techniques
Qualifications
A master’s or bachelor’s degree in relevant field (pharmacy, pharmacology, pharmaceutical sciences, biological chemistry or equivalent in drug metabolism or related discipline) with relevant industry experience in drug discovery/development (+2 years with MS; +5 years with B.S)
Excellent skills in handling and understanding of recombinant and primary cell lines (culture, seeding, storage) is critical
Working experience in in-vitro drug transporters, metabolism, and drug-drug interactions investigations
Working experience with LC-MS/MS based bioanalysis of in vitro experimental samples
Proficiency in data analysis, maintaining electronic notebook, generating accurate reports.
Strong understanding of ADME/DMPK/pharmacokinetics drug dispositions and PK/PD principles and practices
Knowledge in regulatory guidance and in vitro to in vivo extrapolations (IVIVE) such as PBPK modeling and in-silico ADME predictions
Experience conducting in vitro assays with radioisotope and fluorescent labeled compound is required
Working experience with primary hepatocytes, 3D or co-culture models, is a plus
Strong communication and collaboration skills with flexibility to operate in a team environment.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
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AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas – immunology, oncology, neuroscience, and eye care – and products and services in our Allergan Aesthetics portfolio. For more information about AbbVie, please visit us at
www.abbvie.com . Follow @abbvie on
Twitter ,
Facebook ,
Instagram ,
YouTube
and
LinkedIn .
Job Description
The Quantitative, Translational, and ADME Sciences (QTAS) department in AbbVie Bay Area (ABA), CA is seeking a highly motivated transporter scientist to join the In Vitro ADME Science (IVAS) group. The QTAS department supports Discovery and Development Projects by generating in vitro ADME data, pharmacokinetics characterization, prediction of human efficacious dose/pk, drug-drug interactions (DDI) and in vitro to in vivo extrapolations towards the development of clinical candidates. QTAS works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, clinical pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings. In this role, the candidate will be responsible for generating in vitro transporter related data and supporting early discovery to late-stage pipeline.
Core Job Responsibilities:
Conducting in vitro transporter experiments using a wide range of in vitro systems such as recombinant transporter and primary cell lines to support pipeline projects in a timely manner
Cell culture, storage (maintain cell repository-recombinant and primary) and work closely with team members
Conducting primary hepatocytes-based in vitro uptake experiments
Conducting HT-screening for potential inhibition of uptake transporters
Analyzing experimental data and maintaining accurate and comprehensible study documentation in real time
Taking part in scientific development goals to improve data quality, capacity, and introducing new tools and techniques
Qualifications
A master’s or bachelor’s degree in relevant field (pharmacy, pharmacology, pharmaceutical sciences, biological chemistry or equivalent in drug metabolism or related discipline) with relevant industry experience in drug discovery/development (+2 years with MS; +5 years with B.S)
Excellent skills in handling and understanding of recombinant and primary cell lines (culture, seeding, storage) is critical
Working experience in in-vitro drug transporters, metabolism, and drug-drug interactions investigations
Working experience with LC-MS/MS based bioanalysis of in vitro experimental samples
Proficiency in data analysis, maintaining electronic notebook, generating accurate reports.
Strong understanding of ADME/DMPK/pharmacokinetics drug dispositions and PK/PD principles and practices
Knowledge in regulatory guidance and in vitro to in vivo extrapolations (IVIVE) such as PBPK modeling and in-silico ADME predictions
Experience conducting in vitro assays with radioisotope and fluorescent labeled compound is required
Working experience with primary hepatocytes, 3D or co-culture models, is a plus
Strong communication and collaboration skills with flexibility to operate in a team environment.
AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, serving our community and embracing diversity and inclusion. It is AbbVie’s policy to employ qualified persons of the greatest ability without discrimination against any employee or applicant for employment because of race, color, religion, national origin, age, sex (including pregnancy), physical or mental disability, medical condition, genetic information, gender identity or expression, sexual orientation, marital status, status as a protected veteran, or any other legally protected group status.
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