Artech Information System LLC
Scientist
Artech Information System LLC, South San Francisco, California, us, 94083
Artech is the 10th Largest IT Staffing Company in the US, according to Staffing Industry Analysts' 2012 annual report. Artech provides technical expertise to fill gaps in clients' immediate skill-sets availability, deliver emerging technology skill-sets, refresh existing skill base, allow for flexibility in project planning and execution phases, and provide budgeting/financial flexibility by offering contingent labor as a variable cost.Job Description
The candidate must have experience in conducting in vitro ADME assays and familiarity with quantitative bioanalysis
to support development of Client small molecule therapeutics as detailed below:Expertise in conducting in vitro ADME assays
that include stability assays in a variety of biological matrices,
in vitro metabolic stability assays using primary or derived cell lines or other biological matrices, Cytochrome P450 inhibition and induction assays, protein binding assays.Track record of handling and maintaining cell cultures (primary and derived cell lines)
. Familiar with metabolite profiling, identification and/or quantification.Technical expertise in bioanalysis using LC-MS/MS.
Primary responsibilities will include hands-on laboratory work including managing/coordinating daily lab activities, conducting in vitro ADME assays, cell culture, developing bioanalytical LC-MS/MS methods for the quantitative analysis of small molecules, quantitating drug concentrations in various biological matrices, data integration and report writing.The candidate will work closely with senior scientists within the group to support discovery project teams which may include data presentation in team meetings, monitoring DMPK CROs, designing in vivo DMPK studies, data management and presentation.Qualifications
MS degree with 1-3+/3-5+ years of experience in DMPK and/or bioanalytical chemistry or related field.Hands-on knowledge of in vitro DMPK assays, experience with cell culture, and experience in developing LC-MS/MS methods.Knowledge of in vivo pharmacokinetic analysis
is a plus. Good organizational, record keeping, presentation, and communication skills.Must have the ability to work independently with minimal supervision and multitask. Enthusiastic and motivated team player with a can-do attitude.
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The candidate must have experience in conducting in vitro ADME assays and familiarity with quantitative bioanalysis
to support development of Client small molecule therapeutics as detailed below:Expertise in conducting in vitro ADME assays
that include stability assays in a variety of biological matrices,
in vitro metabolic stability assays using primary or derived cell lines or other biological matrices, Cytochrome P450 inhibition and induction assays, protein binding assays.Track record of handling and maintaining cell cultures (primary and derived cell lines)
. Familiar with metabolite profiling, identification and/or quantification.Technical expertise in bioanalysis using LC-MS/MS.
Primary responsibilities will include hands-on laboratory work including managing/coordinating daily lab activities, conducting in vitro ADME assays, cell culture, developing bioanalytical LC-MS/MS methods for the quantitative analysis of small molecules, quantitating drug concentrations in various biological matrices, data integration and report writing.The candidate will work closely with senior scientists within the group to support discovery project teams which may include data presentation in team meetings, monitoring DMPK CROs, designing in vivo DMPK studies, data management and presentation.Qualifications
MS degree with 1-3+/3-5+ years of experience in DMPK and/or bioanalytical chemistry or related field.Hands-on knowledge of in vitro DMPK assays, experience with cell culture, and experience in developing LC-MS/MS methods.Knowledge of in vivo pharmacokinetic analysis
is a plus. Good organizational, record keeping, presentation, and communication skills.Must have the ability to work independently with minimal supervision and multitask. Enthusiastic and motivated team player with a can-do attitude.
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