Senior Scientist, GPCR Pharmacology

United States - Massachusetts - CambridgeWe’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.Role SummaryThe key strategic focus area within the Internal Medicine Research Unit (IMRU) is identifying novel therapies to prevent or treat diseases associated with diabetes or the metabolic syndrome including NASH, obesity, renal disease and heart failure. We aim to build a world class research team dedicated to developing a deep mechanistic understanding of the metabolic pathways and molecular targets underlying disease pathogenesis. As a member of the discovery pharmacology team, you will be playing a significant role in the drug discovery process including validation of novel targets and optimization of effective therapeutics. Experience studying the molecular pharmacology G-protein receptors (GPCRs) is essential and familiarity with the pathophysiology of dysmetabolic states would be advantageous. In addition, the individual will help build and facilitate collaborations with partners in the academic scientific community, as well as within the larger Pfizer network. She/he will have daily interactions with a team of creative and innovative scientists, working collaboratively in a supportive environment to conduct rigorous scientific drug discovery research. Strong self-motivation, excellent communication and interpersonal skills, and the ability to both lead as well as thrive as part of a team are essential.Role ResponsibilitiesSuccessful candidates will be expected to:Independently conceptualize, design and conduct

in vitro

studies aimed at dissecting the complex molecular pharmacology of emerging therapeutic modulators targeting GPCRs.Translate experimental results to advance our understanding of receptor biology and help define how physiological endpoints are impacted by pharmacological agents.Maintain an awareness of ‘cutting edge’ scientific and technical developments in preclinical to clinical translation and apply these to advance the portfolio programs.Apply creative thinking and scientific expertise to the formulation of strategies to identify and validate novel therapeutic targets in key areas of interest to the IMRU.Mentor junior scientists in developing skills essential to the execution of rigorous research.Build and facilitate collaborations with partners in the academic scientific community, as well as within the Pfizer network of scientists.Present research findings to Pfizer colleagues and the scientific community through publication in peer-reviewed journals and talks and posters at scientific meetings.Present and represent research programs to Pfizer leadership.Ensure that all research/discovery work is conducted with highest quality and ethical guidelines and in accordance with relevant regulatory, QC, and compliance guidelines.QualificationsPhD with a minimum of 2 years of post-doc or relevant research experience.Deep expertise in GPCR molecular pharmacology, including hands-on experience with traditional and novel screening methodologies and concepts related to GPCR drug discovery, signaling and trafficking.Scientific rigor with demonstrated ability to review critically available data and think independently and creatively in formulating and testing novel scientific hypotheses.Excellent communication and interpersonal skills and ability to work independently and as part of an interdisciplinary team in a collaborative environment.Successful record of scientific accomplishments supported by previous publications in high-impact pharmacology journals and presentations at international conferences.Ability to mentor junior colleagues both technically and scientifically.Why Patients Need YouPfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most.Relocation support availableWork Location Assignment: On PremiseThe annual base salary for this position ranges from $88,300.00 to $147,100.00. In addition, this position is eligible for participation in Pfizer’s Global Performance Plan with a bonus target of 12.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life’s moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage.Relocation assistance may be available based on business needs and/or eligibility.Sunshine ActPfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations.EEO & Employment EligibilityPfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.

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