GlaxoSmithKline
Associate Scientist, Upstream Process Development
GlaxoSmithKline, King of Prussia, Pennsylvania, United States,
Site Name:
USA - Pennsylvania - King of PrussiaPosted Date:
Oct 4 2024Are you looking for a challenging opportunity that allows you to leverage your technical expertise to accelerate delivery in biopharmaceuticals? If so, this Associate Scientist, Biopharm Drug Substance Development role could be an exciting opportunity to explore.Biopharm Drug Substance Development is a highly experienced Chemistry, Manufacturing and Controls (CMC) organization accountable for delivering robust, cost-effective and competitive products and manufacturing processes spanning the full life-cycle of asset development from Discovery through commercialization. These activities are delivered through state-of-the-art internal facilities as well as strategic external partners.As an Associate Scientist in Upstream Process Development, you will be a member of a highly skilled team of scientists and engineers responsible for the evaluation and optimization of cell culture processes. Your primary focus will be on the scale-up and demonstration of mammalian cell culture unit operations supporting demonstration batches of 50 or 200 L scale. You will also be involved in all aspects of the development of cell culture processes including initial process screening, optimization and characterization, scale-up and tech transfer to clinical manufacturing and/or commercial manufacturing partners for therapeutic proteins.This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following:Perform large scale studies (50 or 200 L scale) to demonstrate cell culture processes for therapeutic protein production.Maintain a state-of-the-art 200L bioreactor laboratory and ensure adherence to departmental safety practices.Perform small-scale studies to develop or characterize cell culture processes.Document experiments accurately and in a timely manner.Support transfer of processes to cGMP manufacturing facilities.Author technical reports and relevant sections of regulatory filings.Interact with key partners (process development scientists, analytical scientists, manufacturing colleagues, and statisticians).Basic Qualifications:Bachelor’s or Master’s degree in Biology/Biochemistry/Chemical Engineering or related discipline with at least 2 years industrial experience.Experience with general laboratory procedures.Excellent oral and written communication skills.Preferred Qualifications:Basic understanding of cellular metabolism, protein synthesis, and monoclonal antibody manufacturing operations.Experience in cell culture process development, technology transfer, or manufacturing operations.Experience in operation of large-scale single use bioreactors (50L and larger).Ability to analyse experimental results using statistical software or modelling tools.Experience with writing technical reports.*LI-GSKGSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people. Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive.
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USA - Pennsylvania - King of PrussiaPosted Date:
Oct 4 2024Are you looking for a challenging opportunity that allows you to leverage your technical expertise to accelerate delivery in biopharmaceuticals? If so, this Associate Scientist, Biopharm Drug Substance Development role could be an exciting opportunity to explore.Biopharm Drug Substance Development is a highly experienced Chemistry, Manufacturing and Controls (CMC) organization accountable for delivering robust, cost-effective and competitive products and manufacturing processes spanning the full life-cycle of asset development from Discovery through commercialization. These activities are delivered through state-of-the-art internal facilities as well as strategic external partners.As an Associate Scientist in Upstream Process Development, you will be a member of a highly skilled team of scientists and engineers responsible for the evaluation and optimization of cell culture processes. Your primary focus will be on the scale-up and demonstration of mammalian cell culture unit operations supporting demonstration batches of 50 or 200 L scale. You will also be involved in all aspects of the development of cell culture processes including initial process screening, optimization and characterization, scale-up and tech transfer to clinical manufacturing and/or commercial manufacturing partners for therapeutic proteins.This role will provide YOU the opportunity to lead key activities to progress YOUR career, these responsibilities include some of the following:Perform large scale studies (50 or 200 L scale) to demonstrate cell culture processes for therapeutic protein production.Maintain a state-of-the-art 200L bioreactor laboratory and ensure adherence to departmental safety practices.Perform small-scale studies to develop or characterize cell culture processes.Document experiments accurately and in a timely manner.Support transfer of processes to cGMP manufacturing facilities.Author technical reports and relevant sections of regulatory filings.Interact with key partners (process development scientists, analytical scientists, manufacturing colleagues, and statisticians).Basic Qualifications:Bachelor’s or Master’s degree in Biology/Biochemistry/Chemical Engineering or related discipline with at least 2 years industrial experience.Experience with general laboratory procedures.Excellent oral and written communication skills.Preferred Qualifications:Basic understanding of cellular metabolism, protein synthesis, and monoclonal antibody manufacturing operations.Experience in cell culture process development, technology transfer, or manufacturing operations.Experience in operation of large-scale single use bioreactors (50L and larger).Ability to analyse experimental results using statistical software or modelling tools.Experience with writing technical reports.*LI-GSKGSK is a global biopharma company with a special purpose – to unite science, technology and talent to get ahead of disease together – so we can positively impact the health of billions of people. Our success absolutely depends on our people. While getting ahead of disease together is about our ambition for patients and shareholders, it’s also about making GSK a place where people can thrive.
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