Takeda Pharmaceutical
Research Senior Scientist: IO Biology Cell Engagers
Takeda Pharmaceutical, Boston, Massachusetts, United States, 02203
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Takedas
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I further attest that all information I submit in my employment application
is
true to the best of my knowledge.
Job DescriptionAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Research Senior Scientist: IO Biology Cell Engagers in our Cambridge office.At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver
Better Health and a Brighter Future
to people around the world.Here, you will be a vital contributor to our inspiring, bold mission.Objective / Purpose:The Cell Engager team of Takeda's Oncology Drug Discovery Unit is seeking a highly motivated in vitro and ex vivo lab-based scientist with a background in Immunology and/or pharmacology to join a collaborative and dynamic team and contribute to pre-clinical projects within oncology research. The candidate must have in-depth knowledge of T cell Biology as well as immune dysfunctional mechanisms in the tumor microenvironment and a strong foundation in in vitro assay development. The candidate will be responsible for critical path activities with demonstrated skills in immuno-oncology drug discovery and will play a critical role in supporting key pipeline programs tied to various immune engaging mechanisms. The position will require the individual to be hands-on, and to collaborate and demonstrate effective documentation and communication of results with key stakeholders in the company. Ideal applicant will be team-oriented, possess excellent communication and organizational skills.Accountabilities:
Independently design and conduct various in vitro assays to assess therapeutic potential of new immune cell engager designs and platforms, ADCs or potential combination therapiesContribute towards new idea generation for pipeline growth and advancementDesign and execute in vitro and ex vivo functional assays to characterize therapeutic candidates as part of the lead selection process, including target tumor antigen expression, T cell immunophenotyping, T cell dependent cytotoxicity, proliferation and cytokine release assaysContribute to new ideas and concept generation aligned with Cell Engager strategy and initiate investigation of new experimental approaches to specific problems using scientific theory, data from external partners, and technical literatureServe as the in vitro lead on projects, as needed, providing key scientific feedback to advance programs in a matrixed environment.Co-ordinate external collaborations with CROs as required and establish new protocols where necessaryExecute experiments with minimum supervision and deliver comprehensive high quality data sets to enable decision makingIsolate and phenotype key cell types such as ?? T cells, VD1 gd T cells from primary sources like leukopacks, PBMCs, skin biopsies etcKeep up with published literature centered around cancer targets and IO therapies relevant to the Takedas CE strategyIdentify, plan and execute well defined scientific projects and communicate program strategy and timelines to management.Utilize relevant information, technology and resources, contributing to complex teamAbility to multi-task effectively, prioritize and independently manage own workloadContribute to IND report and documentationScientifically independentPrepare and present comprehensive technical or project reports and formal presentationsMaintain high quality experimental documentation on laboratory notebooks and follow laboratory practices in compliance with Takeda policiesEducation & Competencies :
PhD in Immunology, Cell Biology, Pharmacology, Biochemistry or similar field with 5+ years of relevant experience, or MS with 9+ years experience or BS 12+ years with previous industry experience strongly preferredCurrent knowledge of oncology research, drug discovery and development with an emphasis on immune cell activation, checkpoint blockade, as well as markers for anti-tumor efficacyHighly skilled with multiparameter FACS and its application in measuring T cell activation, proliferation, cytokine production and identification of immune cell subsetsHands-on experience and ability to work with minimum supervision with standard molecular biology techniques (PCR, cloning etc), ELISA, MSD, Incucyte and other standard cell based, and non-cell based biochemical assays is requiredExperience with biologics is a must (Antibodies, ADCs)Experience with cell therapies, cell engineering and gene editing is preferredExtensive hands-on experience and knowledge in a wide range of immunological assays using cell lines and primary immune cells to design new approaches for immune engaging mechanisms with a focus on biologics discovery and development is expectedProficient in the isolation, culture, and functional characterization of primary human immune cellsUse of scientific databases and application for data management and data analysis (GraphPad Prism, Soft Max Pro, Office 365, FlowJo etc)Excellent written and verbal communication skillsExcellent team player with a can-do attitude with an ability to thrive in a dynamic biotech-like environment and work in cross-functional project teamsInnovative and critical thinkingSelf-motivated, collaborative with excellent time management and organizational skillsTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by lawThis position is currently classified as hybrid in accordance with Takedas Hybrid and Remote Work policy.#LI-JT1
Takeda Compensation and Benefits Summary
We understand compensation is
an important factor
as you consider the next step in your career. We are committed to
equitable
pay for all employees, and we strive to be more transparent with our pay practices.
For Location:Boston, MAU.S. Base Salary Range:$133,000.00 - $209,000.00The estimated salary range reflects
an anticipated
range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education
attained
, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.
?
The actual base salary offered will be
in accordance with
state or local minimum wage requirements for the job location.
U.S. based
e
mployee
s
may be eligible for
s
hort
-
t
erm and/
or
l
ong-
t
erm
incentive
s
.
U.S.
based employees
may be
eligible to
participate
in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and
well-being
benefits, among others. U.S.
based employees are also eligible to receive, per calendar year, up to
80 hours
of sick time, and new hires are eligible to
accrue
up to
120 hours of paid vacation.
EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
LocationsBoston, MA
Worker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time By applying, you consent to your information being transmitted by Jobcase to the Employer, as data controller, through the Employers data processor SonicJobs.See Takeda Pharmaceutical Terms of Use at https://www.takeda.com/terms-of-use/ and Privacy Policy at https://www.takeda.com/privacy-notice/ and SonicJobs Privacy Policy at https://www.sonicjobs.com/us/privacy-policy and Terms of Use at https://www.sonicjobs.com/us/terms-conditions
the information I provide in my application will be processed in line with
Takedas
Privacy Notice
and
Terms of Use .
I further attest that all information I submit in my employment application
is
true to the best of my knowledge.
Job DescriptionAre you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Research Senior Scientist: IO Biology Cell Engagers in our Cambridge office.At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver
Better Health and a Brighter Future
to people around the world.Here, you will be a vital contributor to our inspiring, bold mission.Objective / Purpose:The Cell Engager team of Takeda's Oncology Drug Discovery Unit is seeking a highly motivated in vitro and ex vivo lab-based scientist with a background in Immunology and/or pharmacology to join a collaborative and dynamic team and contribute to pre-clinical projects within oncology research. The candidate must have in-depth knowledge of T cell Biology as well as immune dysfunctional mechanisms in the tumor microenvironment and a strong foundation in in vitro assay development. The candidate will be responsible for critical path activities with demonstrated skills in immuno-oncology drug discovery and will play a critical role in supporting key pipeline programs tied to various immune engaging mechanisms. The position will require the individual to be hands-on, and to collaborate and demonstrate effective documentation and communication of results with key stakeholders in the company. Ideal applicant will be team-oriented, possess excellent communication and organizational skills.Accountabilities:
Independently design and conduct various in vitro assays to assess therapeutic potential of new immune cell engager designs and platforms, ADCs or potential combination therapiesContribute towards new idea generation for pipeline growth and advancementDesign and execute in vitro and ex vivo functional assays to characterize therapeutic candidates as part of the lead selection process, including target tumor antigen expression, T cell immunophenotyping, T cell dependent cytotoxicity, proliferation and cytokine release assaysContribute to new ideas and concept generation aligned with Cell Engager strategy and initiate investigation of new experimental approaches to specific problems using scientific theory, data from external partners, and technical literatureServe as the in vitro lead on projects, as needed, providing key scientific feedback to advance programs in a matrixed environment.Co-ordinate external collaborations with CROs as required and establish new protocols where necessaryExecute experiments with minimum supervision and deliver comprehensive high quality data sets to enable decision makingIsolate and phenotype key cell types such as ?? T cells, VD1 gd T cells from primary sources like leukopacks, PBMCs, skin biopsies etcKeep up with published literature centered around cancer targets and IO therapies relevant to the Takedas CE strategyIdentify, plan and execute well defined scientific projects and communicate program strategy and timelines to management.Utilize relevant information, technology and resources, contributing to complex teamAbility to multi-task effectively, prioritize and independently manage own workloadContribute to IND report and documentationScientifically independentPrepare and present comprehensive technical or project reports and formal presentationsMaintain high quality experimental documentation on laboratory notebooks and follow laboratory practices in compliance with Takeda policiesEducation & Competencies :
PhD in Immunology, Cell Biology, Pharmacology, Biochemistry or similar field with 5+ years of relevant experience, or MS with 9+ years experience or BS 12+ years with previous industry experience strongly preferredCurrent knowledge of oncology research, drug discovery and development with an emphasis on immune cell activation, checkpoint blockade, as well as markers for anti-tumor efficacyHighly skilled with multiparameter FACS and its application in measuring T cell activation, proliferation, cytokine production and identification of immune cell subsetsHands-on experience and ability to work with minimum supervision with standard molecular biology techniques (PCR, cloning etc), ELISA, MSD, Incucyte and other standard cell based, and non-cell based biochemical assays is requiredExperience with biologics is a must (Antibodies, ADCs)Experience with cell therapies, cell engineering and gene editing is preferredExtensive hands-on experience and knowledge in a wide range of immunological assays using cell lines and primary immune cells to design new approaches for immune engaging mechanisms with a focus on biologics discovery and development is expectedProficient in the isolation, culture, and functional characterization of primary human immune cellsUse of scientific databases and application for data management and data analysis (GraphPad Prism, Soft Max Pro, Office 365, FlowJo etc)Excellent written and verbal communication skillsExcellent team player with a can-do attitude with an ability to thrive in a dynamic biotech-like environment and work in cross-functional project teamsInnovative and critical thinkingSelf-motivated, collaborative with excellent time management and organizational skillsTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by lawThis position is currently classified as hybrid in accordance with Takedas Hybrid and Remote Work policy.#LI-JT1
Takeda Compensation and Benefits Summary
We understand compensation is
an important factor
as you consider the next step in your career. We are committed to
equitable
pay for all employees, and we strive to be more transparent with our pay practices.
For Location:Boston, MAU.S. Base Salary Range:$133,000.00 - $209,000.00The estimated salary range reflects
an anticipated
range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education
attained
, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.
?
The actual base salary offered will be
in accordance with
state or local minimum wage requirements for the job location.
U.S. based
e
mployee
s
may be eligible for
s
hort
-
t
erm and/
or
l
ong-
t
erm
incentive
s
.
U.S.
based employees
may be
eligible to
participate
in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and
well-being
benefits, among others. U.S.
based employees are also eligible to receive, per calendar year, up to
80 hours
of sick time, and new hires are eligible to
accrue
up to
120 hours of paid vacation.
EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
LocationsBoston, MA
Worker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time By applying, you consent to your information being transmitted by Jobcase to the Employer, as data controller, through the Employers data processor SonicJobs.See Takeda Pharmaceutical Terms of Use at https://www.takeda.com/terms-of-use/ and Privacy Policy at https://www.takeda.com/privacy-notice/ and SonicJobs Privacy Policy at https://www.sonicjobs.com/us/privacy-policy and Terms of Use at https://www.sonicjobs.com/us/terms-conditions