Takeda Pharmaceutical
Research Associate Scientist, Investigative Toxicology
Takeda Pharmaceutical, Boston, Massachusetts, United States, 02203
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Job DescriptionOBJECTIVES:The Global Investigative Toxicology team is a cross-functional team of scientists that aim to detect and de-risk toxicity in Takedas portfolio to help make medicines safer and more effective. We are looking for a Research Associate Scientist to support these efforts across small molecule, biologics and cell therapy platforms. The Research Associate Scientist will contribute ideas and deliver decision-making data to inform design and prioritization of drug candidates.Work as part of a global team of safety assessment scientists to detect and de-risk toxicities associated various modalitiesDesign and implement early safety assessment screening strategies to enable the progression of optimized therapeutic candidatesConduct cell-based
in vitro
assays to characterize immune-mediated toxicities for medicines in discovery & developmentDevelop novel
in vitro
model systems to assess safety risks associated with new therapeutic designs
ACCOUNTABILITIES:Develop, design, execute, and interpret
in vitro
cell-based assays to characterize diverse mechanisms of drug candidatesMaintain cultures of immortalized tumor cell lines, primary cell types of various origin (lung, liver, kidney, intestine, pancreas, etc.), and primary immune cells (T cells, B cells, NK cells, etc.)Perform fit-for-purpose
ex vivo
analyses to assess phenotypic and functional correlates of toxicityPrepare experimental protocols, analyze experimental data, and present study results in team and department meetingsContribute ideas to drive innovation within investigative toxicology and with key collaborators (e.g. pharmacology, DMPK, bioinformatics)Document experimental methods and findings in electronic laboratory notebookEDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:MS. with 3+ years or BS with 5+ years of experience in immunology, biology, biochemistry, pharmacology, or a related discipline.Expert with standard aseptic cell culture technique, including experience culturing various tumor cell lines and primary cells.Broad experience with cell-based functional assays, including cytotoxicity, cytokine release, and proliferation assays. Experience with flow cytometry is highly preferred.Basic experience with molecular biology techniques including RNA/DNA extraction, qPCR, western blotExperience working in a matrixed team environment at a pharmaceutical company and/or CROBroad scientific knowledge in immunology and pharmacologySelf-motivated with strong time management and organizational skillsAbility to balance multiple projects and flexible with changing prioritiesHighly collaborative with demonstrated ability to work in a matrixed team environmentExcellent oral and written communication skillsLICENSES/CERTIFICATIONS:PHYSICAL DEMANDS:Routine demands of an office based environment.TRAVEL REQUIREMENTS:Ability to travel domestically and internationally,Takeda Compensation and Benefits Summary
We understand compensation is
an important factor
as you consider the next step in your career. We are committed to
equitable
pay for all employees, and we strive to be more transparent with our pay practices.
For Location:Boston, MAU.S. Base Salary Range:$96,600.00 - $151,800.00The estimated salary range reflects
an anticipated
range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education
attained
, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.
?
The actual base salary offered will be
in accordance with
state or local minimum wage requirements for the job location.
U.S. based
e
mployee
s
may be eligible for
s
hort
-
t
erm and/
or
l
ong-
t
erm
incentive
s
.
U.S.
based employees
may be
eligible to
participate
in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and
well-being
benefits, among others. U.S.
based employees are also eligible to receive, per calendar year, up to
80 hours
of sick time, and new hires are eligible to
accrue
up to
120 hours of paid vacation.
EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
LocationsBoston, MA
Worker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time By applying, you consent to your information being transmitted by Jobcase to the Employer, as data controller, through the Employers data processor SonicJobs.See Takeda Pharmaceutical Terms of Use at https://www.takeda.com/terms-of-use/ and Privacy Policy at https://www.takeda.com/privacy-notice/ and SonicJobs Privacy Policy at https://www.sonicjobs.com/us/privacy-policy and Terms of Use at https://www.sonicjobs.com/us/terms-conditions
the information I provide in my application will be processed in line with
Takedas
Privacy Notice
and
Terms of Use .
I further attest that all information I submit in my employment application
is
true to the best of my knowledge.
Job DescriptionOBJECTIVES:The Global Investigative Toxicology team is a cross-functional team of scientists that aim to detect and de-risk toxicity in Takedas portfolio to help make medicines safer and more effective. We are looking for a Research Associate Scientist to support these efforts across small molecule, biologics and cell therapy platforms. The Research Associate Scientist will contribute ideas and deliver decision-making data to inform design and prioritization of drug candidates.Work as part of a global team of safety assessment scientists to detect and de-risk toxicities associated various modalitiesDesign and implement early safety assessment screening strategies to enable the progression of optimized therapeutic candidatesConduct cell-based
in vitro
assays to characterize immune-mediated toxicities for medicines in discovery & developmentDevelop novel
in vitro
model systems to assess safety risks associated with new therapeutic designs
ACCOUNTABILITIES:Develop, design, execute, and interpret
in vitro
cell-based assays to characterize diverse mechanisms of drug candidatesMaintain cultures of immortalized tumor cell lines, primary cell types of various origin (lung, liver, kidney, intestine, pancreas, etc.), and primary immune cells (T cells, B cells, NK cells, etc.)Perform fit-for-purpose
ex vivo
analyses to assess phenotypic and functional correlates of toxicityPrepare experimental protocols, analyze experimental data, and present study results in team and department meetingsContribute ideas to drive innovation within investigative toxicology and with key collaborators (e.g. pharmacology, DMPK, bioinformatics)Document experimental methods and findings in electronic laboratory notebookEDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:MS. with 3+ years or BS with 5+ years of experience in immunology, biology, biochemistry, pharmacology, or a related discipline.Expert with standard aseptic cell culture technique, including experience culturing various tumor cell lines and primary cells.Broad experience with cell-based functional assays, including cytotoxicity, cytokine release, and proliferation assays. Experience with flow cytometry is highly preferred.Basic experience with molecular biology techniques including RNA/DNA extraction, qPCR, western blotExperience working in a matrixed team environment at a pharmaceutical company and/or CROBroad scientific knowledge in immunology and pharmacologySelf-motivated with strong time management and organizational skillsAbility to balance multiple projects and flexible with changing prioritiesHighly collaborative with demonstrated ability to work in a matrixed team environmentExcellent oral and written communication skillsLICENSES/CERTIFICATIONS:PHYSICAL DEMANDS:Routine demands of an office based environment.TRAVEL REQUIREMENTS:Ability to travel domestically and internationally,Takeda Compensation and Benefits Summary
We understand compensation is
an important factor
as you consider the next step in your career. We are committed to
equitable
pay for all employees, and we strive to be more transparent with our pay practices.
For Location:Boston, MAU.S. Base Salary Range:$96,600.00 - $151,800.00The estimated salary range reflects
an anticipated
range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education
attained
, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job.
?
The actual base salary offered will be
in accordance with
state or local minimum wage requirements for the job location.
U.S. based
e
mployee
s
may be eligible for
s
hort
-
t
erm and/
or
l
ong-
t
erm
incentive
s
.
U.S.
based employees
may be
eligible to
participate
in medical, dental, vision insurance, a 401(k) plan and company match, short-term and long-term disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and
well-being
benefits, among others. U.S.
based employees are also eligible to receive, per calendar year, up to
80 hours
of sick time, and new hires are eligible to
accrue
up to
120 hours of paid vacation.
EEO StatementTakeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.
LocationsBoston, MA
Worker TypeEmployeeWorker Sub-TypeRegularTime TypeFull time By applying, you consent to your information being transmitted by Jobcase to the Employer, as data controller, through the Employers data processor SonicJobs.See Takeda Pharmaceutical Terms of Use at https://www.takeda.com/terms-of-use/ and Privacy Policy at https://www.takeda.com/privacy-notice/ and SonicJobs Privacy Policy at https://www.sonicjobs.com/us/privacy-policy and Terms of Use at https://www.sonicjobs.com/us/terms-conditions