Senior Scientist (Drug Development)

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.ROLE SUMMARYPfizer’s Drug Product Design group is seeking team members with a desire to bring new, cutting-edge medicines to patients around the world. Our team members use science and technology to design, characterize and develop drug product formulations from candidate selection to commercial launch. You will be able to leverage your existing scientific knowledge, as well as develop in new areas, to evaluate the chemical & physical stability, bio-performance and manufacturability of the drug product across a diverse range of therapeutic areas.You will be responsible for formulation and manufacturing process design of pharmaceutical oral dosage forms (for new drug candidates and product enhancement programs). You will participate in multi-disciplinary teams during the formulation development, process scale up, and technology transfer of conventional and continuous processing technologies including immediate release, modified release, pediatric and other specialized technologies to our clinical and commercial manufacturing sites in the Pfizer Global Supply organization.You may serve as the Drug Product or Formulation Lead on matrix project teams and must be a strong team player with excellent communication skills working in a complex cross-functional environment. This position also offers the opportunity for cross-training and growth in multiple technical areas to encourage a flexible working environment. Enjoy the entrepreneurial mindset and infrastructure to develop new technologies and processes for drug delivery and dosage form manufacture while having access to the resources of a larger company.The role requires knowledge of pharmaceutical, materials science, physical chemistry and engineering principles as applied to the design of solid dosage forms, biopharmaceutics, pharmacokinetics and advancement of drug delivery platforms for immediate and modified release including pediatric design.As a member of the Drug Product Design group, you will interact closely with other Pharm Sci partner lines (e.g. Analytical R&D, Chemical R&D, Global CMC, Pharm Sci Operations, Drug Product Supply, Quality Assurance) and other lines involved in developing drug assets such as Clinical Pharmacology, Clinical Sciences, Pharmacology & Drug Metabolism and Pfizer Global Supply.Finally, this position will challenge you to pursue scientific excellence and creativity, in collaboration with industry-leading experts across multiple scientific disciplines.Role ResponsibilitiesLeverages expert technical knowledge in chemistry, pharmaceutics, engineering and/or materials science fundamentals to the design and development of immediate and modified release formulations and manufacturing process understanding.Designs and executes laboratory and computational experiments to support novel solid oral drug delivery platforms such as amorphous solid dispersions, initiatives, and portfolio-driven projects. Operates and maintains laboratory equipment to produce and characterize formulated drug products.Develop or partner on strategic collaborations with academic and industrial researchers for addressing gaps in fundamental or applied science related to various drug delivery systems (e.g. amorphous solid dispersions, hot-melt extrusion).Guides scientific direction and project decisions through applying biopharmaceutical and biological principles to influence drug product development.Applies and advances predictive sciences and computational approaches to understand mechanical and physio-chemical characteristics of pharmaceutical compounds and formulations to assess drug product performance and drive team decisions.Leads or supports departmental technology and continuous improvement initiatives.Seeks collaboration and develops novel methodologies with cross-disciplinary teams to solve problems and align on development strategies.Authors regulatory documents supporting drug product development, including relevant drug product sections of IND submissions and CTD applications and associated queries to regulatory agencies.Effectively mentors other scientists in their area of expertise.Strives to grow scientifically contributes to current scientific literature and influences both the external and internal environment.Minimum QualificationsBA/BS with 8+ years of experience, MS with 5+ or PhD with 0 to 4 years of experience in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or allied discipline.Preferred QualificationsExtensive practical experience working within department and/or cross-disciplinary project teams and achieving results in a matrix environment.Experience in actively developing and advancing scientific initiatives and external collaborations. Strong track record of peer-reviewed publications in scientific journals and/or external scientific presentations at industry conferences is a plus.Excellent organizational and communication (oral and written) skills.Ability to work independently, as well as collaboratively.A strong interest and motivation to learn and implement new technologies and concepts.Experience in developing amorphous solid dispersion.Work Location Assignment: On Premise with relocation support availablePHYSICAL/MENTAL REQUIREMENTSPerforming experiments in the lab using small and large scale equipment, lifting, sitting, standing, walking, bending, ability to perform mathematical calculations and ability to perform complex data analysis.NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTSOccasional travel may be required for in-person meetings, conferences, or project support.

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