Principal Scientist, Materials Science

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place.To fully realize Pfizer’s purpose – Breakthroughs that change patients’ lives – we have established a clear set of expectations regarding “what” we need to achieve for patients and “how” we will go about achieving those goals.Pfizer Research & Development serves as the beating heart of Pfizer's trailblazing product pipeline, the essence of our mission to bring life-changing medicines to the world.Pfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues.Pfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy or supporting clinical trials, you will apply cutting-edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.What You Will AchieveWhen you join Pfizer, you'll be joining a company and team with a desire to bring new, cutting-edge medicines to patients around the world. As a member of our team, you'll use science and technology to design, characterize and develop the solid form of active pharmaceutical ingredient (API) and drug product formulations from discovery to commercial launch. You will leverage your existing scientific knowledge, as well as develop in new areas, to evaluate the chemical & physical stability, bio-performance, and manufacturability of the drug product across a diverse range of therapeutic areas.As a pharmaceutical materials characterization scientist, you will utilize our advanced solid-state analytical laboratory to understand and optimize the solid-state structure and particle attributes of Pfizer small molecule drug products. You will be recognized as a technical expert and a significant scientific contributor. With your deep knowledge of the discipline, you will regularly contribute at the therapeutic area level and can represent the department on multidisciplinary teams. You will be entrusted with setting objectives and planning resource requirements for your project team. You will use your scientific judgment to adapt standard methods and techniques by applying prior work experience. You will undertake mentoring activities to guide team members.Through your expertise and extensive knowledge, you will be able to foster a culture that promotes innovation and thrives on doing better for patients and healthcare.How You Will Achieve ItUse solid-state analytical techniques such as x-ray diffraction, thermal methods, IR/Raman spectroscopy, and microscopy as well as mapping and imaging techniques to develop high-quality materials and evaluate physical stability of these materials in formulations.Where required, develop methods to detect and monitor API form of the drug substance in the drug product.Apply advanced organic solid-state structural knowledge to solve scientific problems by integrating solid-state laboratory data with theoretical methodologies. Provide expert interpretation and contextualization of experimental data to make recommendations for further studies and quality control strategies.Participate on multidisciplinary project teams and partner with colleagues to define and recommend screening and characterization strategies according to project timelines and work with crystallization and formulation scientists to optimize materials properties for enhanced performance of drug products.Coach, mentor, and collaborate with colleagues within DPD as well as across Pharmaceutical Sciences, contingent workers, and industrial trainees as needed.Design and oversee work packages of external partners, provide tactical guidance and critical analysis of raw data.Maintain a contemporary in-depth appreciation of the application of state-of-the-art solid-state and particle analytics to the development of API and pharmaceutical dosage forms and improving our workflows.Author scientific proposals for collaboration with internal and external partners and support the authorship of development reports and regulatory submission documents (e.g., Common Technical Dossier for drug product filings).QualificationsMust-HaveA Ph.D. in Pharmaceutics, Chemistry, Engineering, Materials Science, (or equivalent subject) with at least 4 years of relevant experience is required, or a MS in Chemistry, Engineering, Materials Science, or Pharmaceutics (or equivalent subject) and at least 9 years of relevant experience is needed.Experience in powder x-ray diffraction, thermal methods, IR/Raman spectroscopy, and microscopy is essential.Strong data analysis skills and knowledge of statistical concepts are also needed.A strong interest and motivation to learn new technologies and concepts is expected.Good organizational skills, the ability to work independently, and excellent oral and written communication skills are required.Lead the development of new scientific approaches and knowledge within the global Material Sciences organization.Nice-to-HaveWorking knowledge of the physical properties needed for drug substance and formulation components (excipients and polymers) to manufacture robust drug products is desirable.Fundamental understanding of crystallization and preparation of salts and co-crystal forms and solvates, hydrates, and polymorphs of drug candidates and evaluate these forms for acceptability as drug substances as it relates to chemical manufacturing and formulation into pharmaceutical products.Understanding of particle characterization techniques and the impact of particle and powder properties on drug product performance is advantageous for the role.Experience with using contemporary computational approaches to predict the properties and performance of pharmaceutical materials is desired.Experience in formulation design for preclinical studies as well as pharmacokinetic modeling and simulations using GastroPlus, SimCU, or Phoenix is preferred.Experience in characterization of amorphous solid dispersions and DES techniques is an advantage.Deep knowledge of the fundamental physical chemistry and materials science concepts such as thermodynamics, kinetics, crystallization, physics of states such as amorphous and crystalline phases, in addition to your strong analytical and mathematical skillset will be critical in this role.Why Patients Need YouPfizer’s purpose is to deliver breakthroughs that change patients’ lives. Research and Development is at the heart of fulfilling Pfizer’s purpose as we work to translate advanced science and technologies into the therapies and vaccines that matter most. Whether you are in the discovery sciences, ensuring drug safety and efficacy, or supporting clinical trials, you will apply cutting-edge design and process development capabilities to accelerate and bring the best-in-class medicines to patients around the world.Benefits at PfizerPfizer offers competitive compensation and benefits programs designed to meet the diverse needs of our colleagues. Our Pay for Performance Philosophy and Practices reward colleagues based on the contributions they make to our business.Our Competitive Benefits Programs help our colleagues by:Promoting Health and Wellness

to help colleagues maintain and improve their physical and mental wellbeing.Strengthening Colleagues’ Financial Security

by providing company contributions to retirement plans, life insurance, and financial planning education to help colleagues achieve their financial goals.Providing Benefits and Time off for the Moments that Matter

to ensure Pfizer colleagues have the time away from the office to recharge, recover, and return to work as the best version of themselves.And so much more , depending on your country and site, Pfizer offers childcare facilities or discount programs, on-site health and/or fitness centers, movement and mindfulness solutions, “Log in for your Day” work flexibility and so much more.

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