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University of California San Francisco

Specialist in Molecular Biology of Neurons

University of California San Francisco, San Francisco, California, United States, 94199


Specialist in Molecular Biology of Neurons

The Institute for Neurodegenerative Diseases (IND) at the University of California, San Francisco (UCSF) is seeking a motivated individual to join our neuroscience research institute aimed at defining mechanisms underlying motor neuron disease (ALS) and dementia. The IND is directed by Dr. Stanley Prusiner and is located at UCSF’s Mission Bay campus.

The Mordes Lab within the IND focuses on understanding how disruptions in protein homeostasis and RNA metabolism result in neurodegeneration. The research involves patient-derived and CRISPR-edited pluripotent stem cell lines and neuropathology examination of patient brains.

The specialist will engage in studies of human stem cell-derived neurons to model neurodegenerative diseases. The successful applicant will be an experienced cell and molecular biology researcher with expertise in biomedical research and in vitro cell culture methods, effectively communicating with lab members.

Major Responsibilities:

Maintenance and manipulation of stem cell lines, differentiation of stem cells to neurons, and imaging/monitoring of cells via microscopy.

Molecular biology techniques, including quantitative analysis of gene expression, purification of RNA and DNA, and immunoblotting.

Extraction and quality control of nucleic acid and proteins from brain tissue samples.

Complete safety training and maintain lab EH&S and chemical compliance.

Establish additional molecular biology techniques as projects evolve.

Maintain detailed lab records and perform analysis of results using software like GraphPad Prism.

A two-year commitment is preferred; candidates must be able to commit for at least one year.

The specialist will support the intellectual design of research projects, attend and present at lab meetings, and contribute to the scientific community through conferences and publications.

Personal Qualifications Required:

High commitment to advancing biomedical research.

Excellent record-keeping and organizational abilities.

Strong sense of responsibility with lab duties.

Education and Training Qualifications Required:

Junior Specialist: Baccalaureate degree in relevant fields or four years of research experience.

Assistant Specialist: Master’s degree in relevant fields or a baccalaureate degree with three years of research experience.

Associate Specialist: Master’s degree or five to ten years of relevant experience.

Full Specialist: Terminal degree or ten or more years of relevant experience.

Technical Qualifications Required:

Experience in mammalian cell culture and experimental protocols.

Knowledge of basic lab techniques and molecular biology methods.

Ability to perform basic mathematical calculations and statistical tests.

Preferred Qualifications:

Expertise in human pluripotent stem cell maintenance and differentiation.

Experience in biochemistry and molecular biology techniques.

Candidates must meet the qualifications at the time of appointment. CV must state qualifications upon submission.

Please apply online at

https://apptrkr.com/5743765 , with a CV, cover letter, and three references.

APPLICATION REQUIREMENTS:

Curriculum Vitae - must list current and/or pending qualifications.

Cover Letter

Reference requirements: 3 required (contact information only)

UC San Francisco seeks candidates whose experience prepares them to contribute to our commitment to diversity and excellence. The University of California is an Equal Opportunity/Affirmative Action Employer.

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