Bristol-Myers Squibb
Principal Scientist, Early Translational Computational Science for Immunology, C
Bristol-Myers Squibb, Princeton, New Jersey, us, 08543
Principal Scientist, Early Translational Computational Science for Immunology, Cardiovascular and Neurology
Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. When you join BMS, you are joining a diverse, high-achieving team united by a common mission. The Informatics and Predictive Sciences (IPS) mission is to Pioneer, Partner and Predict to drive transformative insights for patient benefit. IPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning—across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS. We perform innovative science to empower key data-driven decisions across a rich pipeline of next-generation medicines. In doing so, our work transforms the lives of patients, as well as our own lives and careers. We seek a creative and passionate computational scientist with a background in addressing translational questions to join the Immunology, Cardiovascular and Neurology (ICN) Early Translational team within Informatics and Predictive Sciences, a globally distributed group driving innovative computational research for discovery and early development. In this role, you will implement rigorous data analysis practices and align resources based on scientific priorities to lead analyzes of high-dimensional readouts from longitudinal patient cohorts. Your analyses will identify biomarkers predictive of patient outcomes and response to therapy and inform drug development and safety pipeline. We are seeking a highly motivated bioinformatician with preclinical or clinical experience to join our Early Translational ICN team. The successful candidate will help advance Bristol Myers Squibb’s ICN clinical programs through the strategic application of cutting-edge bioinformatics approaches. Responsibilities Analyze various -omic-scale biomarker data generated from human subjects in clinical trials and other observational cohorts, including RNA-Seq, Exome, and Whole Genome Sequencing, high throughput proteomics, and multiplex flow cytometry to validate pharmacodynamics effects, confirm the mechanism of action, and enable patient enrichment strategies. Conduct analysis independently to integrate and mine large-scale external datasets to further our understanding of diseases in Immunology and Neurology. Work both independently and collaboratively to extract insights, generate hypotheses and guide drug development decisions in our Early Clinical, Development and Translational teams and help inform our development pipeline. Basic Qualifications: Bachelor's Degree 8+ years of academic / industry experience Or Master's Degree 6+ years of academic / industry experience Or PhD 4+ years of academic / industry experience Preferred Qualifications Ph.D. in bioinformatics, molecular biology, genetics, engineering, statistics, or a similar discipline. Four (4) or more years relevant experience in preclinical or clinical research. Proficiency using R required and 1+ additional programming language preferred. Strong experience in statistical modeling and/or machine learning approaches, such as mixed-effects models, predictive modeling, etc. to represent biological concepts. Experience with clinical database (SDTM/ADaM) and biomarker statistical analysis is a plus. Individual contributor role requiring strong background in -omic (DNA, RNA, epigenetic, proteomic) data analysis and biological interpretation. Prior experience in immunology or neurology is a plus. Strong problem-solving and collaboration skills, rigorous and creative thinking. Ability to communicate effectively with biologists, clinicians and other computational scientists. The starting compensation for this job is a range from
$
119,000 - 149,000, plus incentive cash and stock opportunities (based on eligibility). Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as “Transforming patients’ lives through science”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
#J-18808-Ljbffr
Working with Us Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. When you join BMS, you are joining a diverse, high-achieving team united by a common mission. The Informatics and Predictive Sciences (IPS) mission is to Pioneer, Partner and Predict to drive transformative insights for patient benefit. IPS conducts applied computational research in areas that include genomic, structural and molecular informatics, computational and systems biology, patient selection and translational biomarker research, and broader fields including knowledge science, epidemiology and machine learning—across the full lifecycle of drug discovery and development and across all therapeutic areas at BMS. We perform innovative science to empower key data-driven decisions across a rich pipeline of next-generation medicines. In doing so, our work transforms the lives of patients, as well as our own lives and careers. We seek a creative and passionate computational scientist with a background in addressing translational questions to join the Immunology, Cardiovascular and Neurology (ICN) Early Translational team within Informatics and Predictive Sciences, a globally distributed group driving innovative computational research for discovery and early development. In this role, you will implement rigorous data analysis practices and align resources based on scientific priorities to lead analyzes of high-dimensional readouts from longitudinal patient cohorts. Your analyses will identify biomarkers predictive of patient outcomes and response to therapy and inform drug development and safety pipeline. We are seeking a highly motivated bioinformatician with preclinical or clinical experience to join our Early Translational ICN team. The successful candidate will help advance Bristol Myers Squibb’s ICN clinical programs through the strategic application of cutting-edge bioinformatics approaches. Responsibilities Analyze various -omic-scale biomarker data generated from human subjects in clinical trials and other observational cohorts, including RNA-Seq, Exome, and Whole Genome Sequencing, high throughput proteomics, and multiplex flow cytometry to validate pharmacodynamics effects, confirm the mechanism of action, and enable patient enrichment strategies. Conduct analysis independently to integrate and mine large-scale external datasets to further our understanding of diseases in Immunology and Neurology. Work both independently and collaboratively to extract insights, generate hypotheses and guide drug development decisions in our Early Clinical, Development and Translational teams and help inform our development pipeline. Basic Qualifications: Bachelor's Degree 8+ years of academic / industry experience Or Master's Degree 6+ years of academic / industry experience Or PhD 4+ years of academic / industry experience Preferred Qualifications Ph.D. in bioinformatics, molecular biology, genetics, engineering, statistics, or a similar discipline. Four (4) or more years relevant experience in preclinical or clinical research. Proficiency using R required and 1+ additional programming language preferred. Strong experience in statistical modeling and/or machine learning approaches, such as mixed-effects models, predictive modeling, etc. to represent biological concepts. Experience with clinical database (SDTM/ADaM) and biomarker statistical analysis is a plus. Individual contributor role requiring strong background in -omic (DNA, RNA, epigenetic, proteomic) data analysis and biological interpretation. Prior experience in immunology or neurology is a plus. Strong problem-solving and collaboration skills, rigorous and creative thinking. Ability to communicate effectively with biologists, clinicians and other computational scientists. The starting compensation for this job is a range from
$
119,000 - 149,000, plus incentive cash and stock opportunities (based on eligibility). Uniquely Interesting Work, Life-changing Careers With a single vision as inspiring as “Transforming patients’ lives through science”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
#J-18808-Ljbffr